hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12618.1
Complex Portal: CPX-20017
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | 5 | UniProt NCBI |
| MCTS1 | Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies) | 5 | UniProt NCBI |
| SYT5 | Synaptotagmin-5 (Synaptotagmin V) (SytV) | 5 | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | 5 | UniProt NCBI |
| TRMT10A | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | 5 | UniProt NCBI |
| SYT1 | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) | 5 | UniProt NCBI |
| SYT2 | Synaptotagmin-2 (Synaptotagmin II) (SytII) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001321 | 0.00660611471141 | 0.666666666667 | AFF3 SYT2 VLDLR TRMT10A | Cerebellar hypoplasia |
| HP:0007360 | 0.0116729789752 | 0.666666666667 | AFF3 SYT2 VLDLR TRMT10A | Aplasia/Hypoplasia of the cerebellum |
| HP:0005943 | 0.0297012565438 | 0.333333333333 | AFF3 SYT2 | Respiratory arrest |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SYT2 | SYT1 | 1.0 |
mutually_exclusive (O00445)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| SYT5 | SYT1 | 0.991 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VLDLR | SYT1 | 0.983 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SYT2 | SYT5 | 0.979 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRMT10A | SYT2 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MCTS1 | SYT1 | 0.961 | 0.076 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AFF3 | SYT2 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| VLDLR | SYT2 | 0.895 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| AFF3 | TRMT10A | 0.415 | bioplex3_WMM WMM_only | ||
| VLDLR | SYT5 | 0.299 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRMT10A | SYT5 | 0.214 | bioplex3_WMM WMM_only | ||
| AFF3 | SYT5 | 0.146 | bioplex3_WMM WMM_only | ||
| VLDLR | TRMT10A | 0.113 | 0.07 | bioplex3_WMM WMM_only | |
| TRMT10A | SYT1 | 0.078 | 0.072 | bioplex3_WMM WMM_only | |
| VLDLR | AFF3 | 0.078 | bioplex3_WMM WMM_only | ||
| AFF3 | SYT1 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes