hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12625.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CACNB4 | Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4) | 5 | UniProt NCBI |
| ZFY | Zinc finger Y-chromosomal protein | 5 | UniProt NCBI |
| CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | 5 | UniProt NCBI |
| CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | 5 | UniProt NCBI |
| CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112308 | 1.4947902785e-11 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Presynaptic depolarization and calcium channel opening |
| REAC:R-HSA-419037 | 7.4870963414e-09 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | NCAM1 interactions |
| REAC:R-HSA-375165 | 4.77117693363e-08 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | NCAM signaling for neurite out-growth |
| WP:WP2118 | 7.49968526102e-08 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05412 | 1.03657872165e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04260 | 1.3091933685e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Cardiac muscle contraction |
| GO:0008331 | 1.31622611039e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | high voltage-gated calcium channel activity |
| KEGG:05414 | 1.63229922449e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Dilated cardiomyopathy |
| KEGG:05410 | 1.63229922449e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Hypertrophic cardiomyopathy |
| GO:0007528 | 9.61435992643e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | neuromuscular junction development |
| KEGG:04921 | 9.74070084625e-07 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Oxytocin signaling pathway |
| KEGG:04261 | 1.00789524798e-06 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Adrenergic signaling in cardiomyocytes |
| GO:0005245 | 4.13351489328e-06 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated calcium channel activity |
| GO:0005891 | 5.37501604002e-06 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated calcium channel complex |
| WP:WP382 | 1.07905696272e-05 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | MAPK signaling pathway |
| KEGG:04010 | 1.78654941634e-05 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | MAPK signaling pathway |
| REAC:R-HSA-112315 | 2.9019356916e-05 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Transmission across Chemical Synapses |
| GO:0034704 | 3.27930250282e-05 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium channel complex |
| GO:1990454 | 8.06911104389e-05 | 0.6 | CACNB2 CACNB3 CACNB1 | L-type voltage-gated calcium channel complex |
| REAC:R-HSA-112316 | 0.000135335223169 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Neuronal System |
| GO:0005262 | 0.000150799788408 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium channel activity |
| GO:0022843 | 0.000229129100643 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated monoatomic cation channel activity |
| GO:0015085 | 0.000334585912591 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium ion transmembrane transporter activity |
| GO:0061577 | 0.000349481973524 | 0.6 | CACNB2 CACNB3 CACNB1 | calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO:1903169 | 0.00043484599868 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of calcium ion transmembrane transport |
| GO:0022832 | 0.000492677093958 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated channel activity |
| GO:0005244 | 0.000492677093958 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | voltage-gated monoatomic ion channel activity |
| REAC:R-HSA-5576893 | 0.000683310775372 | 0.4 | CACNB2 CACNB1 | Phase 2 - plateau phase |
| REAC:R-HSA-422475 | 0.000923896701883 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Axon guidance |
| GO:1901385 | 0.000929874009882 | 0.6 | CACNB2 CACNB4 CACNB3 | regulation of voltage-gated calcium channel activity |
| REAC:R-HSA-9675108 | 0.00106922987368 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Nervous system development |
| GO:0034703 | 0.00148410028721 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | cation channel complex |
| GO:0051924 | 0.00188884895508 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of calcium ion transport |
| REAC:R-HSA-400042 | 0.00350190276731 | 0.4 | CACNB2 CACNB3 | Adrenaline,noradrenaline inhibits insulin secretion |
| GO:0034702 | 0.00407551040215 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | monoatomic ion channel complex |
| REAC:R-HSA-5576892 | 0.00418294558639 | 0.4 | CACNB2 CACNB1 | Phase 0 - rapid depolarisation |
| GO:0030315 | 0.00475337188383 | 0.6 | CACNB2 CACNB3 CACNB1 | T-tubule |
| GO:0022836 | 0.00526877477961 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | gated channel activity |
| GO:0070588 | 0.00563530898302 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium ion transmembrane transport |
| GO:1904062 | 0.00563530898302 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of monoatomic cation transmembrane transport |
| GO:0034765 | 0.00825090824596 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of monoatomic ion transmembrane transport |
| GO:0005261 | 0.00841882816967 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | monoatomic cation channel activity |
| REAC:R-HSA-1266738 | 0.00896294496653 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | Developmental Biology |
| WP:WP5356 | 0.00931707261303 | 0.4 | CACNB2 CACNB1 | Affected pathways in Duchenne muscular dystrophy |
| GO:0050808 | 0.0125732528527 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | synapse organization |
| GO:0010959 | 0.0130363720333 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of metal ion transport |
| GO:0006816 | 0.0175068921761 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | calcium ion transport |
| GO:1902495 | 0.0187071120569 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | transmembrane transporter complex |
| GO:0043269 | 0.0233977310013 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of monoatomic ion transport |
| GO:1901019 | 0.0237169649094 | 0.6 | CACNB2 CACNB4 CACNB3 | regulation of calcium ion transmembrane transporter activity |
| GO:0046873 | 0.0237634346833 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | metal ion transmembrane transporter activity |
| GO:0005216 | 0.0252691756905 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | monoatomic ion channel activity |
| GO:1990351 | 0.025656507175 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | transporter complex |
| GO:1901843 | 0.0280843539964 | 0.4 | CACNB2 CACNB3 | positive regulation of high voltage-gated calcium channel activity |
| GO:0034762 | 0.0302165890257 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | regulation of transmembrane transport |
| REAC:R-HSA-422356 | 0.0313469851718 | 0.4 | CACNB2 CACNB3 | Regulation of insulin secretion |
| WP:WP536 | 0.0360146352745 | 0.4 | CACNB1 CACNB3 | Calcium regulation in cardiac cells |
| GO:0015267 | 0.0384230454852 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | channel activity |
| GO:0022803 | 0.0389526852651 | 0.8 | CACNB2 CACNB3 CACNB4 CACNB1 | passive transmembrane transporter activity |
| GO:0042383 | 0.0417184596383 | 0.6 | CACNB2 CACNB3 CACNB1 | sarcolemma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CACNB3 | CACNB2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB3 | CACNB1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB2 | CACNB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CACNB4 | CACNB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB4 | CACNB2 | 0.902 | bioplex3_WMM WMM_only | |
| CACNB3 | ZFY | 0.843 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes