hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12631.1
Complex Portal: CPX-11749
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4P2 | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | 5 | UniProt NCBI |
| TSPYL4 | Testis-specific Y-encoded-like protein 4 (TSPY-like protein 4) | 4 | UniProt NCBI |
| DFFB | DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40) | 5 | UniProt NCBI |
| DFFA | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | 5 | UniProt NCBI |
| OC90 | Otoconin-90 (Oc90) (Phospholipase A2 homolog) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-140342 | 0.0011839189519 | 0.4 | DFFB DFFA | Apoptosis induced DNA fragmentation |
| WP:WP314 | 0.0041146517648 | 0.4 | DFFB DFFA | Fas ligand pathway and stress induction of heat shock proteins |
| GO:1902511 | 0.00468200720083 | 0.4 | DFFB DFFA | negative regulation of apoptotic DNA fragmentation |
| GO:1903625 | 0.00468200720083 | 0.4 | DFFB DFFA | negative regulation of DNA catabolic process |
| WP:WP4298 | 0.0144790152013 | 0.4 | DFFB DFFA | Acute viral myocarditis |
| WP:WP254 | 0.0153080129813 | 0.4 | DFFB DFFA | Apoptosis |
| WP:WP1772 | 0.0174803785097 | 0.4 | DFFB DFFA | Apoptosis modulation and signaling |
| REAC:R-HSA-75153 | 0.0177620315324 | 0.4 | DFFB DFFA | Apoptotic execution phase |
| KEGG:04210 | 0.0319348346673 | 0.4 | DFFB DFFA | Apoptosis |
| GO:1902510 | 0.0468008499735 | 0.4 | DFFB DFFA | regulation of apoptotic DNA fragmentation |
| GO:1903624 | 0.0468008499735 | 0.4 | DFFB DFFA | regulation of DNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DFFA | DFFB | 1.0 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TSPYL4 | DFFA | 1.0 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIP4P2 | DFFB | 0.997 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| OC90 | PIP4P2 | 0.964 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TSPYL4 | DFFB | 0.921 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only | |
| DFFA | PIP4P2 | 0.902 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes