hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12633.1
Complex Portal: CPX-24991
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARL3 | ADP-ribosylation factor-like protein 3 | 5 | UniProt NCBI |
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| TBC1D10A | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | 5 | UniProt NCBI |
| UBL3 | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | 4 | UniProt NCBI |
| RAB28 | Ras-related protein Rab-28 | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4803 | 1.32197107333e-05 | 0.666666666667 | INPP5E RAB28 ARL3 PDE6D | Ciliopathies |
| CORUM:6741 | 5.12534978153e-05 | 0.333333333333 | PDE6D INPP5E | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 7.74455426548e-05 | 0.333333333333 | PDE6D INPP5E | ARL13B-mediated ciliary trafficking of INPP5E |
| REAC:R-HSA-5620920 | 0.000106578184795 | 0.5 | INPP5E ARL3 PDE6D | Cargo trafficking to the periciliary membrane |
| WP:WP4656 | 0.0001559950529 | 0.5 | INPP5E ARL3 PDE6D | Joubert syndrome |
| HP:0002419 | 0.000176135758605 | 0.5 | INPP5E ARL3 PDE6D | Molar tooth sign on MRI |
| WP:WP5234 | 0.000191724000413 | 0.5 | INPP5E ARL3 PDE6D | Bardet Biedl syndrome |
| HP:0002876 | 0.000541046995004 | 0.5 | INPP5E ARL3 PDE6D | Episodic tachypnea |
| HP:0004422 | 0.00085820130959 | 0.5 | INPP5E ARL3 PDE6D | Biparietal narrowing |
| HP:0002418 | 0.00153388121466 | 0.5 | INPP5E ARL3 PDE6D | Abnormal midbrain morphology |
| HP:0002789 | 0.0026840867676 | 0.5 | INPP5E ARL3 PDE6D | Tachypnea |
| HP:0001696 | 0.00378495258144 | 0.5 | INPP5E ARL3 PDE6D | Situs inversus totalis |
| HP:0011933 | 0.00388470114881 | 0.333333333333 | ARL3 INPP5E | Elongated superior cerebellar peduncle |
| HP:0011534 | 0.00403597422216 | 0.5 | INPP5E ARL3 PDE6D | Abnormal spatial orientation of the cardiac segments |
| HP:0000657 | 0.00443283482612 | 0.5 | INPP5E ARL3 PDE6D | Oculomotor apraxia |
| HP:0011932 | 0.00485499013014 | 0.333333333333 | ARL3 INPP5E | Abnormal superior cerebellar peduncle morphology |
| HP:0002084 | 0.00530249442786 | 0.5 | INPP5E ARL3 PDE6D | Encephalocele |
| HP:0011815 | 0.00530249442786 | 0.5 | INPP5E ARL3 PDE6D | Cephalocele |
| HP:0001651 | 0.00645180628587 | 0.5 | INPP5E ARL3 PDE6D | Dextrocardia |
| HP:0004307 | 0.00662835320171 | 0.5 | INPP5E ARL3 PDE6D | Abnormal anatomic location of the heart |
| HP:0011931 | 0.00711805296098 | 0.333333333333 | ARL3 INPP5E | Abnormal cerebellar peduncle morphology |
| HP:0001829 | 0.0075592305979 | 0.5 | INPP5E ARL3 PDE6D | Foot polydactyly |
| REAC:R-HSA-5617833 | 0.00760491079328 | 0.5 | INPP5E ARL3 PDE6D | Cilium Assembly |
| HP:0009136 | 0.00836335600305 | 0.5 | INPP5E ARL3 PDE6D | Duplication involving bones of the feet |
| HP:0002335 | 0.00841070885474 | 0.333333333333 | PDE6D INPP5E | Agenesis of cerebellar vermis |
| HP:0012501 | 0.00841070885474 | 0.333333333333 | ARL3 INPP5E | Abnormal brainstem white matter morphology |
| HP:0034237 | 0.00967270294092 | 0.5 | INPP5E ARL3 PDE6D | Open neural tube defect |
| HP:0004362 | 0.0111110959064 | 0.5 | INPP5E ARL3 PDE6D | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.0111110959064 | 0.5 | INPP5E ARL3 PDE6D | Aganglionic megacolon |
| HP:0025028 | 0.0113637882169 | 0.5 | INPP5E ARL3 PDE6D | Abnormal enteric nervous system morphology |
| HP:0012331 | 0.0113637882169 | 0.5 | INPP5E ARL3 PDE6D | Abnormal autonomic nervous system morphology |
| HP:0001161 | 0.0182726158894 | 0.5 | INPP5E ARL3 PDE6D | Hand polydactyly |
| HP:0000612 | 0.0197023659792 | 0.5 | INPP5E ARL3 PDE6D | Iris coloboma |
| REAC:R-HSA-1852241 | 0.0232310173112 | 0.5 | INPP5E ARL3 PDE6D | Organelle biogenesis and maintenance |
| HP:0000662 | 0.0261590153267 | 0.5 | RAB28 ARL3 INPP5E | Nyctalopia |
| HP:0002553 | 0.0266033265904 | 0.5 | INPP5E ARL3 PDE6D | Highly arched eyebrow |
| HP:0002126 | 0.0270525934689 | 0.5 | INPP5E ARL3 PDE6D | Polymicrogyria |
| HP:0007973 | 0.0297012565438 | 0.333333333333 | PDE6D INPP5E | Retinal dysplasia |
| HP:0002186 | 0.0313233529835 | 0.5 | INPP5E ARL3 PDE6D | Apraxia |
| HP:0009997 | 0.0399718389151 | 0.5 | INPP5E ARL3 PDE6D | Duplication of phalanx of hand |
| HP:0009142 | 0.0405591774535 | 0.5 | INPP5E ARL3 PDE6D | Duplication of bones involving the upper extremities |
| HP:0004275 | 0.0405591774535 | 0.5 | INPP5E ARL3 PDE6D | Duplication of hand bones |
| HP:0002104 | 0.0411521790966 | 0.5 | INPP5E ARL3 PDE6D | Apnea |
| HP:0000426 | 0.0429654221844 | 0.5 | INPP5E ARL3 PDE6D | Prominent nasal bridge |
| WP:WP4536 | 0.0470586139423 | 0.333333333333 | ARL3 INPP5E | Genes related to primary cilium development based on CRISPR |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBL3 | PDE6D | 0.999 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PDE6D | INPP5E | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | RAB28 | 0.998 | 0.174 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| PDE6D | TBC1D10A | 0.997 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ARL3 | PDE6D | 0.985 | 0.282 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| INPP5E | RAB28 | 0.946 | bioplex3_WMM WMM_only | ||
| TBC1D10A | INPP5E | 0.931 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| UBL3 | INPP5E | 0.923 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| TBC1D10A | RAB28 | 0.826 | 0.116 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| UBL3 | TBC1D10A | 0.72 | 0.076 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | INPP5E | 0.676 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| ARL3 | TBC1D10A | 0.656 | 0.05 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| UBL3 | RAB28 | 0.527 | 0.114 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| UBL3 | ARL3 | 0.328 | 0.064 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| ARL3 | RAB28 | 0.313 | 0.192 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
Related Complexes