hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12636.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SKI | Ski oncogene (Proto-oncogene c-Ski) | 5 | UniProt NCBI |
| RGS10 | Regulator of G-protein signaling 10 (RGS10) | 5 | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | 5 | UniProt NCBI |
| MPND | MPN domain-containing protein (EC 3.4.-.-) | 5 | UniProt NCBI |
| SKIL | Ski-like protein (Ski-related oncogene) (Ski-related protein) | 5 | UniProt NCBI |
| SMAD4 | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | 5 | UniProt NCBI |
| JMJD1C | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3038 | 1.36501667663e-05 | 0.4 | SMAD2 SMAD4 | SMAD2-SMAD4-FAST1 complex |
| CORUM:3739 | 1.36501667663e-05 | 0.4 | SMAD2 SMAD4 | SKI-SMAD2-SMAD4 pentameric complex |
| CORUM:3233 | 4.09448956317e-05 | 0.4 | SMAD2 SMAD4 | SMAD2-SMAD4-FAST1-TGIF complex, TGF(beta) induced |
| CORUM:2834 | 4.09448956317e-05 | 0.4 | SMAD2 SMAD4 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:6646 | 4.09448956317e-05 | 0.4 | SMAD2 SMAD4 | SMAD2-SMAD4-WWTR1 complex |
| CORUM:3753 | 4.09448956317e-05 | 0.4 | SMAD2 SMAD4 | CREBBP-SMAD2-SMAD4 pentameric complex |
| REAC:R-HSA-3311021 | 4.55977246808e-05 | 0.4 | SMAD2 SMAD4 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 4.55977246808e-05 | 0.4 | SMAD2 SMAD4 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3315487 | 4.55977246808e-05 | 0.4 | SMAD2 SMAD4 | SMAD2/3 MH2 Domain Mutants in Cancer |
| CORUM:3234 | 8.18785830799e-05 | 0.4 | SMAD2 SMAD4 | SMAD2-SMAD4-FAST1-TGIF-HDAC1 complex, TGF(beta) induced |
| REAC:R-HSA-3304349 | 0.000151950811602 | 0.4 | SMAD2 SMAD4 | Loss of Function of SMAD2/3 in Cancer |
| REAC:R-HSA-3304351 | 0.000227895019208 | 0.4 | SMAD2 SMAD4 | Signaling by TGF-beta Receptor Complex in Cancer |
| WP:WP2853 | 0.000294729719483 | 0.6 | RGS10 SMAD4 SMAD2 | Endoderm differentiation |
| WP:WP5382 | 0.0003876755558 | 0.4 | SMAD2 SMAD4 | TGF Smad signaling pathway |
| WP:WP2857 | 0.000397455973038 | 0.6 | RGS10 SMAD4 SMAD2 | Mesodermal commitment pathway |
| CORUM:2829 | 0.000490935356523 | 0.4 | SMAD2 SMAD4 | RSmad complex |
| REAC:R-HSA-9823730 | 0.000546723465219 | 0.4 | SMAD2 SMAD4 | Formation of definitive endoderm |
| WP:WP3859 | 0.000616503269292 | 0.4 | SMAD2 SMAD4 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition |
| WP:WP3874 | 0.000616503269292 | 0.4 | SMAD2 SMAD4 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-1502540 | 0.000683310775372 | 0.4 | SMAD2 SMAD4 | Signaling by Activin |
| REAC:R-HSA-9754189 | 0.00100191474811 | 0.4 | SMAD2 SMAD4 | Germ layer formation at gastrulation |
| WP:WP5103 | 0.00100346979189 | 0.4 | SMAD2 SMAD4 | Progeria associated lipodystrophy |
| WP:WP3668 | 0.00161852668418 | 0.4 | SMAD2 SMAD4 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| REAC:R-HSA-9617828 | 0.0018206657072 | 0.4 | SMAD2 SMAD4 | FOXO-mediated transcription of cell cycle genes |
| REAC:R-HSA-452723 | 0.0018206657072 | 0.4 | SMAD2 SMAD4 | Transcriptional regulation of pluripotent stem cells |
| WP:WP4838 | 0.00190535175424 | 0.4 | SMAD2 SMAD4 | Regucalcin in proximal tubule epithelial kidney cells |
| WP:WP2870 | 0.00221546358612 | 0.4 | SMAD2 SMAD4 | Extracellular vesicle mediated signaling in recipient cells |
| REAC:R-HSA-1181150 | 0.00232071308473 | 0.4 | SMAD2 SMAD4 | Signaling by NODAL |
| HP:0001166 | 0.00296757123606 | 0.6 | SMAD2 JMJD1C SMAD4 | Arachnodactyly |
| WP:WP4535 | 0.0041146517648 | 0.4 | SMAD2 SMAD4 | Envelope proteins and their potential roles in EDMD physiopathology |
| REAC:R-HSA-9615017 | 0.00454605723789 | 0.4 | SMAD2 SMAD4 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| GO:0032444 | 0.00468200720083 | 0.4 | SMAD2 SMAD4 | activin responsive factor complex |
| HP:0025423 | 0.00509344150575 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormal larynx morphology |
| WP:WP560 | 0.00528162918062 | 0.4 | SMAD2 SMAD4 | TGF beta receptor signaling |
| HP:0001238 | 0.00532560182507 | 0.6 | SMAD2 JMJD1C SMAD4 | Slender finger |
| WP:WP4816 | 0.00578890329638 | 0.4 | SMAD2 SMAD4 | TGF beta receptor signaling in skeletal dysplasias |
| REAC:R-HSA-2173795 | 0.0061489605225 | 0.4 | SMAD2 SMAD4 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| WP:WP5144 | 0.00631928190743 | 0.4 | SMAD2 SMAD4 | NRP1 triggered signaling pathways in pancreatic cancer |
| HP:0001646 | 0.00744020362032 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormal aortic valve morphology |
| WP:WP5356 | 0.00931707261303 | 0.4 | SMAD2 SMAD4 | Affected pathways in Duchenne muscular dystrophy |
| REAC:R-HSA-2173796 | 0.00953234360475 | 0.4 | SMAD2 SMAD4 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| HP:0032079 | 0.00979150178217 | 0.4 | SMAD2 SMAD4 | Medial degeneration |
| HP:0200146 | 0.00979150178217 | 0.4 | SMAD2 SMAD4 | Mucoid extracellular matrix accumulation |
| HP:0004959 | 0.00979150178217 | 0.4 | SMAD2 SMAD4 | Descending thoracic aorta aneurysm |
| HP:0012180 | 0.00979150178217 | 0.4 | SMAD2 SMAD4 | Cystic medial necrosis |
| REAC:R-HSA-9758941 | 0.0100756681589 | 0.4 | SMAD2 SMAD4 | Gastrulation |
| HP:0012432 | 0.0109419445801 | 0.4 | SMAD2 SMAD4 | Chronic fatigue |
| HP:0012763 | 0.0109419445801 | 0.4 | SMAD2 SMAD4 | Paroxysmal dyspnea |
| HP:0010651 | 0.0113572466436 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormal meningeal morphology |
| KEGG:05212 | 0.0115077320087 | 0.4 | SMAD2 SMAD4 | Pancreatic cancer |
| HP:0012499 | 0.0121560512731 | 0.4 | SMAD2 SMAD4 | Descending aortic dissection |
| HP:0000272 | 0.0123583473737 | 0.6 | SMAD2 JMJD1C SMAD4 | Malar flattening |
| REAC:R-HSA-2173789 | 0.0123986787504 | 0.4 | SMAD2 SMAD4 | TGF-beta receptor signaling activates SMADs |
| WP:WP4216 | 0.0128896073912 | 0.4 | SMAD2 SMAD4 | Chromosomal and microsatellite instability in colorectal cancer |
| WP:WP5345 | 0.0132783799217 | 0.4 | SMAD2 SMAD4 | 1p36 copy number variation syndrome |
| KEGG:05210 | 0.0135091080522 | 0.4 | SMAD2 SMAD4 | Colorectal cancer |
| HP:0004933 | 0.0147751514018 | 0.4 | SMAD2 SMAD4 | Ascending aortic dissection |
| HP:0100775 | 0.0147751514018 | 0.4 | SMAD2 SMAD4 | Dural ectasia |
| HP:0010303 | 0.0161800923797 | 0.4 | SMAD2 SMAD4 | Abnormal spinal meningeal morphology |
| HP:0031784 | 0.0161800923797 | 0.4 | SMAD2 SMAD4 | Abnormal ascending aorta morphology |
| HP:0012163 | 0.0161800923797 | 0.4 | SMAD2 SMAD4 | Carotid artery dilatation |
| HP:0005112 | 0.0161800923797 | 0.4 | SMAD2 SMAD4 | Abdominal aortic aneurysm |
| HP:0001600 | 0.0164434381168 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormality of the larynx |
| KEGG:04933 | 0.0168082536599 | 0.4 | SMAD2 SMAD4 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04350 | 0.0168082536599 | 0.4 | SMAD2 SMAD4 | TGF-beta signaling pathway |
| KEGG:04659 | 0.0179869923441 | 0.4 | SMAD2 SMAD4 | Th17 cell differentiation |
| REAC:R-HSA-2173793 | 0.0184995798233 | 0.4 | SMAD2 SMAD4 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| WP:WP4263 | 0.0188521857166 | 0.4 | SMAD2 SMAD4 | Pancreatic adenocarcinoma pathway |
| HP:0002619 | 0.0207761643339 | 0.4 | SMAD2 JMJD1C | Varicose veins |
| HP:0001933 | 0.0210412528672 | 0.6 | SMAD2 JMJD1C SMAD4 | Subcutaneous hemorrhage |
| HP:0010668 | 0.0210412528672 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormal zygomatic bone morphology |
| HP:0011106 | 0.0241576577336 | 0.4 | SMAD2 SMAD4 | Hypovolemia |
| HP:0011104 | 0.0241576577336 | 0.4 | SMAD2 SMAD4 | Abnormality of blood volume homeostasis |
| HP:0004950 | 0.0241576577336 | 0.4 | SMAD2 SMAD4 | Peripheral arterial stenosis |
| REAC:R-HSA-9614085 | 0.0266933781073 | 0.4 | SMAD2 SMAD4 | FOXO-mediated transcription |
| KEGG:04371 | 0.0273394134018 | 0.4 | SMAD2 SMAD4 | Apelin signaling pathway |
| HP:0002647 | 0.0277928629638 | 0.4 | SMAD2 SMAD4 | Aortic dissection |
| HP:0002138 | 0.0277928629638 | 0.4 | SMAD2 SMAD4 | Subarachnoid hemorrhage |
| KEGG:04550 | 0.0319348346673 | 0.4 | SMAD2 SMAD4 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP5083 | 0.035376376638 | 0.4 | SMAD2 SMAD4 | Neuroinflammation and glutamatergic signaling |
| HP:0005293 | 0.0358235710582 | 0.4 | SMAD2 JMJD1C | Venous insufficiency |
| HP:0002140 | 0.0379894907585 | 0.4 | SMAD2 SMAD4 | Ischemic stroke |
| KEGG:05226 | 0.0380272112444 | 0.4 | SMAD2 SMAD4 | Gastric cancer |
| HP:0002143 | 0.0384213686055 | 0.6 | SMAD2 JMJD1C SMAD4 | Abnormal spinal cord morphology |
| HP:0100807 | 0.0384213686055 | 0.6 | SMAD2 JMJD1C SMAD4 | Long fingers |
| WP:WP179 | 0.0386238148414 | 0.4 | SMAD2 SMAD4 | Cell cycle |
| HP:0025722 | 0.0402186552091 | 0.4 | SMAD2 SMAD4 | Cerebral infarct |
| WP:WP366 | 0.0406395857275 | 0.4 | SMAD2 SMAD4 | TGF beta signaling pathway |
| HP:0000023 | 0.0406422010858 | 0.6 | SMAD2 JMJD1C SMAD4 | Inguinal hernia |
| KEGG:04390 | 0.0471742362289 | 0.4 | SMAD2 SMAD4 | Hippo signaling pathway |
| CORUM:3197 | 0.0498708842806 | 0.2 | SMAD4 | SMAD4-SNO-SKI complex |
| CORUM:3039 | 0.0498708842806 | 0.2 | SMAD2 | SMAD2-FAST1 complex |
| CORUM:3198 | 0.0498708842806 | 0.2 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3729 | 0.0498708842806 | 0.2 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3200 | 0.0498708842806 | 0.2 | SMAD4 | SMAD4-SKI complex |
| WP:WP4239 | 0.0499562127809 | 0.4 | SMAD2 SMAD4 | Epithelial to mesenchymal transition in colorectal cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKIL | SMAD4 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SKI | SMAD4 | 0.996 | 0.124 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SKI | SKIL | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RGS10 | SMAD4 | 0.928 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| SMAD2 | SKIL | 0.923 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| JMJD1C | MPND | 0.902 | 0.106 | bioplex3_WMM WMM_only |
| JMJD1C | SKIL | 0.902 | bioplex3_WMM WMM_only | |
| MPND | SKIL | 0.902 | bioplex3_WMM WMM_only | |
| SMAD2 | SKI | 0.841 | 0.212 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SMAD2 | SMAD4 | 0.772 | 0.176 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| RGS10 | SKIL | 0.418 | bioplex3_WMM WMM_only | |
| RGS10 | SKI | 0.22 | 0.126 | bioplex3_WMM WMM_only |
| SMAD2 | RGS10 | 0.042 | 0.032 | bioplex3_WMM WMM_only |
| JMJD1C | SMAD4 | 0.005 | 0.09 | youn_WMM WMM_only |
Related Complexes