hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12654.1

Complex Portal: CPX-19466

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
FAM185A	Protein FAM185A	2	UniProt NCBI
MT-ND3	NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3)	5	UniProt NCBI
NDUFV3	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4)	5	UniProt NCBI
NDUFC1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial (Complex I-KFYI) (CI-KFYI) (NADH-ubiquinone oxidoreductase KFYI subunit)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:178	8.64074449328e-06	0.75	NDUFV3 MT-ND3 NDUFC1	Respiratory chain complex I (holoenzyme), mitochondrial
WP:WP623	1.13301263399e-05	0.75	NDUFV3 MT-ND3 NDUFC1	Oxidative phosphorylation
REAC:R-HSA-6799198	4.09441910601e-05	0.75	NDUFV3 MT-ND3 NDUFC1	Complex I biogenesis
WP:WP111	5.29024993618e-05	0.75	NDUFV3 MT-ND3 NDUFC1	Electron transport chain OXPHOS system in mitochondria
KEGG:04723	9.34385249616e-05	0.75	NDUFV3 MT-ND3 NDUFC1	Retrograde endocannabinoid signaling
KEGG:00190	0.000100732661973	0.75	NDUFV3 MT-ND3 NDUFC1	Oxidative phosphorylation
REAC:R-HSA-611105	0.000219007946647	0.75	NDUFV3 MT-ND3 NDUFC1	Respiratory electron transport
KEGG:05415	0.000336138721134	0.75	NDUFV3 MT-ND3 NDUFC1	Diabetic cardiomyopathy
CORUM:2919	0.000338026191524	0.5	MT-ND3 NDUFC1	Respiratory chain complex I (gamma subunit) mitochondrial
REAC:R-HSA-163200	0.000401649591062	0.75	NDUFV3 MT-ND3 NDUFC1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:05208	0.000459857531952	0.75	NDUFV3 MT-ND3 NDUFC1	Chemical carcinogenesis - reactive oxygen species
KEGG:04714	0.000480682574607	0.75	NDUFV3 MT-ND3 NDUFC1	Thermogenesis
KEGG:05012	0.00075243962929	0.75	NDUFV3 MT-ND3 NDUFC1	Parkinson disease
KEGG:05020	0.000820802302251	0.75	NDUFV3 MT-ND3 NDUFC1	Prion disease
REAC:R-HSA-1428517	0.00109943198837	0.75	NDUFV3 MT-ND3 NDUFC1	The citric acid (TCA) cycle and respiratory electron transport
KEGG:05016	0.00111064292822	0.75	NDUFV3 MT-ND3 NDUFC1	Huntington disease
KEGG:05014	0.00189623846113	0.75	NDUFV3 MT-ND3 NDUFC1	Amyotrophic lateral sclerosis
KEGG:05010	0.00219039316089	0.75	NDUFV3 MT-ND3 NDUFC1	Alzheimer disease
WP:WP4324	0.00377411060353	0.5	NDUFV3 NDUFC1	Mitochondrial complex I assembly model OXPHOS system
GO:0008137	0.0037914498893	0.75	NDUFV3 MT-ND3 NDUFC1	NADH dehydrogenase (ubiquinone) activity
KEGG:05022	0.00394541346322	0.75	NDUFV3 MT-ND3 NDUFC1	Pathways of neurodegeneration - multiple diseases
GO:0050136	0.00409056451107	0.75	NDUFV3 MT-ND3 NDUFC1	NADH dehydrogenase (quinone) activity
GO:0003954	0.00440499676786	0.75	NDUFV3 MT-ND3 NDUFC1	NADH dehydrogenase activity
GO:0003955	0.00508133939815	0.75	NDUFV3 MT-ND3 NDUFC1	NAD(P)H dehydrogenase (quinone) activity
GO:0006120	0.00544401218013	0.75	NDUFV3 MT-ND3 NDUFC1	mitochondrial electron transport, NADH to ubiquinone
GO:0005747	0.00706693750215	0.75	NDUFV3 MT-ND3 NDUFC1	mitochondrial respiratory chain complex I
GO:0030964	0.00706693750215	0.75	NDUFV3 MT-ND3 NDUFC1	NADH dehydrogenase complex
GO:0045271	0.00706693750215	0.75	NDUFV3 MT-ND3 NDUFC1	respiratory chain complex I
GO:0016655	0.0106287970558	0.75	NDUFV3 MT-ND3 NDUFC1	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0015453	0.0118300289699	0.75	NDUFV3 MT-ND3 NDUFC1	oxidoreduction-driven active transmembrane transporter activity
GO:0042776	0.0152210712647	0.75	NDUFV3 MT-ND3 NDUFC1	proton motive force-driven mitochondrial ATP synthesis
GO:0015986	0.0209740664347	0.75	NDUFV3 MT-ND3 NDUFC1	proton motive force-driven ATP synthesis
WP:WP4396	0.023499356813	0.5	NDUFV3 NDUFC1	Nonalcoholic fatty liver disease
KEGG:04932	0.0237566589162	0.5	NDUFV3 NDUFC1	Non-alcoholic fatty liver disease
GO:0016651	0.0248327141789	0.75	NDUFV3 MT-ND3 NDUFC1	oxidoreductase activity, acting on NAD(P)H
GO:0019646	0.0269276802074	0.75	NDUFV3 MT-ND3 NDUFC1	aerobic electron transport chain
GO:0098803	0.0302857026499	0.75	NDUFV3 MT-ND3 NDUFC1	respiratory chain complex
GO:0006754	0.0339114962397	0.75	NDUFV3 MT-ND3 NDUFC1	ATP biosynthetic process
GO:0042773	0.0339114962397	0.75	NDUFV3 MT-ND3 NDUFC1	ATP synthesis coupled electron transport
GO:0042775	0.0339114962397	0.75	NDUFV3 MT-ND3 NDUFC1	mitochondrial ATP synthesis coupled electron transport
GO:0009145	0.0364824972322	0.75	NDUFV3 MT-ND3 NDUFC1	purine nucleoside triphosphate biosynthetic process
GO:0009206	0.0364824972322	0.75	NDUFV3 MT-ND3 NDUFC1	purine ribonucleoside triphosphate biosynthetic process
GO:0070469	0.0378152735667	0.75	NDUFV3 MT-ND3 NDUFC1	respirasome
GO:0005746	0.0378152735667	0.75	NDUFV3 MT-ND3 NDUFC1	mitochondrial respirasome
GO:0009201	0.0434703685672	0.75	NDUFV3 MT-ND3 NDUFC1	ribonucleoside triphosphate biosynthetic process
GO:0022904	0.0464975978221	0.75	NDUFV3 MT-ND3 NDUFC1	respiratory electron transport chain
GO:0009142	0.048062454325	0.75	NDUFV3 MT-ND3 NDUFC1	nucleoside triphosphate biosynthetic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
FAM185A	NDUFV3	0.996	0.056	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MT-ND3	NDUFV3	0.958	0.248	bioplex3_HEK293 bioplex3_WMM WMM_only
NDUFV3	NDUFC1	0.843	0.174	bioplex3_HEK293 bioplex3_WMM WMM_only
FAM185A	NDUFC1	0.415	0.09	bioplex3_WMM WMM_only
FAM185A	MT-ND3	0.415	0.0845038216561	bioplex3_WMM WMM_only
MT-ND3	NDUFC1	0.415	0.306	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
FAM185A	huMAP3_00817.1 huMAP3_01729.1 huMAP3_02819.1 huMAP3_06021.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_08660.1 huMAP3_09126.1 huMAP3_09567.1 huMAP3_10025.1 huMAP3_12617.1 huMAP3_12654.1 huMAP3_14878.1
MT-ND3	huMAP3_00817.1 huMAP3_02718.1 huMAP3_02819.1 huMAP3_06397.1 huMAP3_07920.1 huMAP3_08660.1 huMAP3_09567.1 huMAP3_11244.1 huMAP3_12654.1 huMAP3_14743.1 huMAP3_14878.1 huMAP3_15304.1
NDUFV3	huMAP3_00817.1 huMAP3_02819.1 huMAP3_02928.1 huMAP3_06397.1 huMAP3_08660.1 huMAP3_09567.1 huMAP3_09982.1 huMAP3_12654.1 huMAP3_14018.1 huMAP3_14878.1
NDUFC1	huMAP3_12654.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12654.1

Complex Portal: CPX-19466