hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12657.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SPAG6 | Sperm-associated antigen 6 (Protein PF16 homolog) (Repro-SA-1) (Sperm flagellar protein) | 5 | UniProt NCBI |
| SGIP1 | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | 5 | UniProt NCBI |
| CASP5 | Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10] | 5 | UniProt NCBI |
| CASP4 | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620971 | 0.00258893271292 | 0.5 | CASP5 CASP4 | Pyroptosis |
| WP:WP5322 | 0.0122792151382 | 0.5 | CASP5 CASP4 | CKAP4 signaling pathway map |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | CASP5 CASP4 | Regulated Necrosis |
| KEGG:04621 | 0.02620193588 | 0.5 | CASP5 CASP4 | NOD-like receptor signaling pathway |
| GO:0097200 | 0.042122686785 | 0.5 | CASP5 CASP4 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SGIP1 | CASP4 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CASP5 | CASP4 | 0.997 | bioplex3_HEK293 bioplex () bioplex3_WMM | |
| SPAG6 | SGIP1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPAG6 | CASP4 | 0.902 | bioplex3_WMM WMM_only |
Related Complexes