hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12662.1
Complex Portal: CPX-18216
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TAGAP | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | 4 | UniProt NCBI |
| ROCK1 | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | 5 | UniProt NCBI |
| ROCK2 | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | 5 | UniProt NCBI |
| SPRTN | DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4962 | 0.000198998246169 | 0.5 | ROCK1 ROCK2 | Airway smooth muscle cell contraction |
| REAC:R-HSA-8980692 | 0.000453862022785 | 0.75 | TAGAP ROCK1 ROCK2 | RHOA GTPase cycle |
| WP:WP524 | 0.0013446069671 | 0.5 | ROCK1 ROCK2 | G13 signaling pathway |
| REAC:R-HSA-416572 | 0.00175047124894 | 0.5 | ROCK1 ROCK2 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627117 | 0.00175047124894 | 0.5 | ROCK1 ROCK2 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-400685 | 0.00258893271292 | 0.5 | ROCK1 ROCK2 | Sema4D in semaphorin signaling |
| REAC:R-HSA-9013422 | 0.00258893271292 | 0.5 | ROCK1 ROCK2 | RHOBTB1 GTPase cycle |
| GO:0072518 | 0.0028092043205 | 0.5 | ROCK1 ROCK2 | Rho-dependent protein serine/threonine kinase activity |
| GO:1905205 | 0.0028092043205 | 0.5 | ROCK1 ROCK2 | positive regulation of connective tissue replacement |
| WP:WP2272 | 0.00299043061896 | 0.5 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-3928663 | 0.00332479301982 | 0.5 | ROCK1 ROCK2 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-9013407 | 0.00573491177379 | 0.5 | ROCK1 ROCK2 | RHOH GTPase cycle |
| WP:WP2034 | 0.00578263137464 | 0.5 | ROCK1 ROCK2 | Leptin signaling pathway |
| WP:WP1544 | 0.00595470242757 | 0.5 | ROCK1 ROCK2 | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-9706574 | 0.006081926491 | 0.5 | ROCK1 ROCK2 | RHOBTB GTPase Cycle |
| REAC:R-HSA-3928662 | 0.00718390333861 | 0.5 | ROCK1 ROCK2 | EPHB-mediated forward signaling |
| WP:WP138 | 0.00841946044435 | 0.5 | ROCK1 ROCK2 | Androgen receptor signaling pathway |
| WP:WP185 | 0.00883615359641 | 0.5 | ROCK1 ROCK2 | Integrin mediated cell adhesion |
| KEGG:04670 | 0.00909742323246 | 0.5 | ROCK1 ROCK2 | Leukocyte transendothelial migration |
| KEGG:04520 | 0.00909742323246 | 0.5 | ROCK1 ROCK2 | Adherens junction |
| KEGG:04270 | 0.0113396114984 | 0.5 | ROCK1 ROCK2 | Vascular smooth muscle contraction |
| KEGG:04611 | 0.0118173906169 | 0.5 | ROCK1 ROCK2 | Platelet activation |
| KEGG:04071 | 0.0130545606238 | 0.5 | ROCK1 ROCK2 | Sphingolipid signaling pathway |
| REAC:R-HSA-9012999 | 0.0139104893494 | 0.75 | TAGAP ROCK1 ROCK2 | RHO GTPase cycle |
| KEGG:05135 | 0.0162723391924 | 0.5 | ROCK1 ROCK2 | Yersinia infection |
| GO:0110061 | 0.0168521501606 | 0.5 | ROCK1 ROCK2 | regulation of angiotensin-activated signaling pathway |
| GO:1905203 | 0.0168521501606 | 0.5 | ROCK1 ROCK2 | regulation of connective tissue replacement |
| GO:1903347 | 0.0168521501606 | 0.5 | ROCK1 ROCK2 | negative regulation of bicellular tight junction assembly |
| KEGG:04921 | 0.0171315137194 | 0.5 | ROCK1 ROCK2 | Oxytocin signaling pathway |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | ROCK1 ROCK2 | Semaphorin interactions |
| WP:WP3929 | 0.0183400443465 | 0.5 | ROCK1 ROCK2 | Chemokine signaling pathway |
| REAC:R-HSA-9013026 | 0.0186613511621 | 0.5 | ROCK1 ROCK2 | RHOB GTPase cycle |
| KEGG:04022 | 0.0192212154966 | 0.5 | ROCK1 ROCK2 | cGMP-PKG signaling pathway |
| REAC:R-HSA-416482 | 0.019281632575 | 0.5 | ROCK1 ROCK2 | G alpha (12/13) signalling events |
| WP:WP51 | 0.0205195911139 | 0.5 | ROCK1 ROCK2 | Regulation of actin cytoskeleton |
| REAC:R-HSA-9013106 | 0.0212029570934 | 0.5 | ROCK1 ROCK2 | RHOC GTPase cycle |
| KEGG:04530 | 0.0237566589162 | 0.5 | ROCK1 ROCK2 | Tight junction |
| KEGG:04062 | 0.0237566589162 | 0.5 | ROCK1 ROCK2 | Chemokine signaling pathway |
| CORUM:7424 | 0.0249718442456 | 0.25 | ROCK1 | ISLR2-ROCK1 complex |
| GO:0035509 | 0.0280843539964 | 0.5 | ROCK1 ROCK2 | negative regulation of myosin-light-chain-phosphatase activity |
| KEGG:04360 | 0.0291410886797 | 0.5 | ROCK1 ROCK2 | Axon guidance |
| KEGG:04024 | 0.0306683825257 | 0.5 | ROCK1 ROCK2 | cAMP signaling pathway |
| KEGG:05130 | 0.0334335704012 | 0.5 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2682334 | 0.0338007536087 | 0.5 | ROCK1 ROCK2 | EPH-Ephrin signaling |
| REAC:R-HSA-9679191 | 0.0363250695065 | 0.5 | ROCK1 ROCK2 | Potential therapeutics for SARS |
| KEGG:04510 | 0.03673756538 | 0.5 | ROCK1 ROCK2 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | ROCK1 ROCK2 | Focal adhesion |
| REAC:R-HSA-4420097 | 0.0380580405855 | 0.5 | ROCK1 ROCK2 | VEGFA-VEGFR2 Pathway |
| KEGG:05205 | 0.0406374666322 | 0.5 | ROCK1 ROCK2 | Proteoglycans in cancer |
| GO:0097709 | 0.042122686785 | 0.5 | ROCK1 ROCK2 | connective tissue replacement |
| KEGG:05163 | 0.0451972531521 | 0.5 | ROCK1 ROCK2 | Human cytomegalovirus infection |
| REAC:R-HSA-194138 | 0.0453901932463 | 0.5 | ROCK1 ROCK2 | Signaling by VEGF |
| KEGG:04810 | 0.0466115978004 | 0.5 | ROCK1 ROCK2 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ROCK1 | ROCK2 | 0.993 | 0.186 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| ROCK1 | SPRTN | 0.885 | 0.45 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ROCK1 | TAGAP | 0.86 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ROCK2 | TAGAP | 0.542 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ROCK2 | SPRTN | 0.359 | 0.446 | bioplex3_WMM bioplex3_HCT116 WMM_only |
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