hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12663.1
Complex Portal: CPX-12934
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLAAT4 | Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) | 5 | UniProt NCBI |
| ZC2HC1A | Zinc finger C2HC domain-containing protein 1A | 4 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1903577 | 0.0028092043205 | 0.5 | CASTOR2 CASTOR1 | cellular response to L-arginine |
| GO:1903576 | 0.00842684400117 | 0.5 | CASTOR2 CASTOR1 | response to L-arginine |
| REAC:R-HSA-9639288 | 0.0140623832262 | 0.5 | CASTOR2 CASTOR1 | Amino acids regulate mTORC1 |
| KEGG:04150 | 0.0269222811984 | 0.5 | CASTOR2 CASTOR1 | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLAAT4 | CASTOR1 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLAAT4 | CASTOR2 | 0.97 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CASTOR1 | CASTOR2 | 0.917 |
mutually_exclusive (Q9UL19)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR1 | ZC2HC1A | 0.842 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZC2HC1A | CASTOR2 | 0.364 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes