hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12676.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
DUS2	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)	5	UniProt NCBI
PHF20L1	PHD finger protein 20-like protein 1	5	UniProt NCBI
PUS7L	Pseudouridylate synthase PUS7L (EC 5.4.99.-) (Pseudouridylate synthase 7 homolog-like protein)	5	UniProt NCBI
KANSL3	KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)	5	UniProt NCBI
MSL2	E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)	5	UniProt NCBI
KAT8	Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)	5	UniProt NCBI
KANSL2	KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)	5	UniProt NCBI
KANSL1L	KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2)	3	UniProt NCBI
MSL3	Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)	5	UniProt NCBI
MCRS1	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)	5	UniProt NCBI
PHF20	PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)	5	UniProt NCBI
KANSL1	KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)	5	UniProt NCBI
MSL1	Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)	5	UniProt NCBI
C9JHY2		None	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1902562	1.02536145891e-22	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	H4 histone acetyltransferase complex
GO:0044545	2.05872402761e-19	0.615384615385	MCRS1 KANSL1 KANSL3 KAT8 PHF20 PHF20L1 KANSL1L KANSL2	NSL complex
GO:0000123	7.62239262713e-19	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	histone acetyltransferase complex
GO:1902493	2.66504118935e-18	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	acetyltransferase complex
GO:0031248	2.66504118935e-18	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	protein acetyltransferase complex
CORUM:7221	5.98172850128e-16	0.461538461538	MCRS1 KANSL1 KANSL3 PHF20 KAT8 KANSL2	NSL complex
REAC:R-HSA-3214847	4.64696025881e-14	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	HATs acetylate histones
REAC:R-HSA-9772755	3.06105956248e-13	0.538461538462	MCRS1 KANSL1 KANSL3 KAT8 PHF20 PHF20L1 KANSL2	Formation of WDR5-containing histone-modifying complexes
REAC:R-HSA-4839726	1.99948930673e-11	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	Chromatin organization
REAC:R-HSA-3247509	1.99948930673e-11	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	Chromatin modifying enzymes
CORUM:610	2.11387990692e-11	0.307692307692	KANSL1 MSL2 KAT8 MSL3	MSL complex
CORUM:7220	2.11387990692e-11	0.307692307692	MSL2 MSL1 KAT8 MSL3	MSL complex
REAC:R-HSA-212165	1.17300637925e-08	0.538461538462	MCRS1 KANSL1 KANSL3 KAT8 PHF20 PHF20L1 KANSL2	Epigenetic regulation of gene expression
GO:1990234	3.16861477014e-08	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	transferase complex
GO:0140535	5.95294952628e-08	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	intracellular protein-containing complex
GO:0072487	9.40213012535e-08	0.307692307692	MSL2 MSL1 KAT8 MSL3	MSL complex
CORUM:5386	3.12615342348e-07	0.307692307692	KANSL1 MCRS1 KAT8 PHF20	MLL1-WDR5 complex
GO:0000785	3.67746483959e-07	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	chromatin
GO:0032993	6.99927090886e-07	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	protein-DNA complex
GO:0005694	1.90941911955e-05	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	chromosome
GO:1902494	5.04334140174e-05	0.846153846154	KANSL3 KANSL1 MSL2 MCRS1 KAT8 PHF20 KANSL2 KANSL1L MSL1 MSL3 PHF20L1	catalytic complex
GO:0071339	0.000584138163037	0.307692307692	KANSL1 MCRS1 KAT8 PHF20	MLL1 complex
GO:0044665	0.000667257175244	0.307692307692	KANSL1 MCRS1 KAT8 PHF20	MLL1/2 complex
GO:0045893	0.00136615106739	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	positive regulation of DNA-templated transcription
GO:1902680	0.00140068311716	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	positive regulation of RNA biosynthetic process
GO:0051254	0.00370202484434	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	positive regulation of RNA metabolic process
GO:0016070	0.00704644105213	0.923076923077	KANSL3 KANSL1 KANSL2 MSL2 MCRS1 DUS2 PUS7L PHF20 PHF20L1 MSL1 MSL3 KAT8	RNA metabolic process
GO:0035097	0.0116049549349	0.307692307692	KANSL1 MCRS1 KAT8 PHF20	histone methyltransferase complex
GO:0045935	0.0117210993718	0.692307692308	KANSL3 KANSL1 KANSL2 MCRS1 MSL2 PHF20 MSL3 MSL1 KAT8	positive regulation of nucleobase-containing compound metabolic process
REAC:R-HSA-74160	0.0123811504483	0.538461538462	MCRS1 KANSL1 KANSL3 KAT8 PHF20 PHF20L1 KANSL2	Gene expression (Transcription)
GO:0090304	0.0297306500951	0.923076923077	KANSL3 KANSL1 KANSL2 MSL2 MCRS1 DUS2 PUS7L PHF20 PHF20L1 MSL1 MSL3 KAT8	nucleic acid metabolic process
GO:0034708	0.0481684735813	0.307692307692	KANSL1 MCRS1 KAT8 PHF20	methyltransferase complex

Edges

Protein 1	Protein 2	Score	ProteomeHD
PHF20	KANSL3	1.0	0.286
PHF20	KANSL1	0.999	0.41
MSL2	KAT8	0.999	0.146
PHF20L1	KANSL1	0.999	0.19
KANSL2	KANSL1	0.999	0.492
MSL1	KAT8	0.999	0.39
MSL2	MSL3	0.998	0.216
KAT8	KANSL3	0.998	0.18
MCRS1	KANSL1	0.997	0.482
PHF20L1	KANSL3	0.997	0.204
PHF20L1	KAT8	0.997	0.146
PHF20L1	MCRS1	0.997	0.314
PHF20L1	KANSL2	0.997	0.164
MSL1	MSL2	0.996	0.32
KANSL2	PHF20	0.995	0.316
KANSL1	DUS2	0.995	0.046
KANSL1	KAT8	0.994	0.192
MCRS1	PHF20	0.992	0.374
KANSL1	KANSL3	0.991	0.348
MCRS1	KAT8	0.99	0.584
MSL1	MSL3	0.99	0.242
PHF20	KAT8	0.99	0.266
MCRS1	KANSL2	0.99	0.676
KANSL2	KANSL3	0.988	0.534
KANSL1L	PHF20L1	0.984
KANSL3	C9JHY2	0.977
MCRS1	KANSL3	0.954	0.332
PHF20L1	C9JHY2	0.903
KAT8	C9JHY2	0.901
KANSL1	C9JHY2	0.897
MCRS1	MSL1	0.896	0.486
KANSL2	C9JHY2	0.88
KANSL3	PUS7L	0.866	0.088
KAT8	MSL3	0.855	0.17
MCRS1	C9JHY2	0.841
KANSL2	KAT8	0.78	0.278
PHF20	DUS2	0.572	0.07
PHF20L1	DUS2	0.572	0.07
MCRS1	MSL3	0.423	0.248
KANSL1L	KANSL1	0.415
KANSL1L	KANSL3	0.415
KANSL1L	C9JHY2	0.415
KANSL1L	KAT8	0.415
KANSL2	DUS2	0.303	0.122
PHF20L1	PHF20	0.265	0.236
KANSL1	MSL3	0.248	0.18
MSL2	KANSL1	0.248	0.242
PHF20	C9JHY2	0.245
MSL2	KANSL3	0.232	0.232
KANSL1L	KANSL2	0.21
MSL1	KANSL1	0.192	0.394
MCRS1	MSL2	0.192	0.358
KANSL3	MSL3	0.192	0.128
MCRS1	DUS2	0.143	0.076
KANSL2	MSL1	0.089	0.472
KANSL1L	MCRS1	0.078
KAT8	PUS7L	0.078	0.054
MSL1	KANSL3	0.063	0.25

Related Complexes

Genename	Complexes
DUS2	huMAP3_03399.1 huMAP3_03971.1 huMAP3_04875.1 huMAP3_07062.1 huMAP3_10027.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
PHF20L1	huMAP3_00594.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
PUS7L	huMAP3_12676.1 huMAP3_13008.1
KANSL3	huMAP3_04283.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_10106.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL2	huMAP3_03334.1 huMAP3_03404.1 huMAP3_05936.1 huMAP3_06991.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_12676.1
KAT8	huMAP3_03404.1 huMAP3_03971.1 huMAP3_05936.1 huMAP3_07062.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL2	huMAP3_02631.1 huMAP3_06050.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL1L	huMAP3_00594.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL3	huMAP3_05936.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_11792.1 huMAP3_12676.1 huMAP3_15215.1
MCRS1	huMAP3_01995.1 huMAP3_03971.1 huMAP3_06050.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_14133.1 huMAP3_14284.1
PHF20	huMAP3_03399.1 huMAP3_03971.1 huMAP3_07062.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
KANSL1	huMAP3_03399.1 huMAP3_03971.1 huMAP3_04875.1 huMAP3_07062.1 huMAP3_10027.1 huMAP3_10050.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1
MSL1	huMAP3_03334.1 huMAP3_03404.1 huMAP3_05936.1 huMAP3_08116.1 huMAP3_11576.1 huMAP3_12676.1
C9JHY2	huMAP3_04283.1 huMAP3_08515.1 huMAP3_10050.1 huMAP3_10106.1 huMAP3_11576.1 huMAP3_12676.1 huMAP3_13378.1 huMAP3_14284.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12676.1