hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12679.1
Complex Portal: CPX-14378
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| GLS2 | Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase) | 5 | UniProt NCBI |
| OR6Q1 | Olfactory receptor 6Q1 (Olfactory receptor OR11-226) | 3 | UniProt NCBI |
| SPATA2L | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | 5 | UniProt NCBI |
| SPATA2 | Spermatogenesis-associated protein 2 | 5 | UniProt NCBI |
| CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | 5 | UniProt NCBI |
| THEMIS | Protein THEMIS (Thymocyte-expressed molecule involved in selection) | 5 | UniProt NCBI |
| NKX2-5 | Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6296 | 3.41979277617e-05 | 0.181818181818 | CYLD SPATA2 | SPATA2-CYLD complex |
| KEGG:04217 | 0.00641396286278 | 0.272727272727 | SPATA2L SPATA2 CYLD | Necroptosis |
| REAC:R-HSA-5357786 | 0.0364941063676 | 0.181818181818 | CYLD SPATA2 | TNFR1-induced proapoptotic signaling |
| CORUM:2540 | 0.049976851631 | 0.0909090909091 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| CORUM:2892 | 0.049976851631 | 0.0909090909091 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2895 | 0.049976851631 | 0.0909090909091 | GRB2 | SHC-GRB2 complex |
| CORUM:3096 | 0.049976851631 | 0.0909090909091 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GRB2 | GAREM1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GAREM2 | GAREM1 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GAREM1 | OR6Q1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GRB2 | CYLD | 0.994 | 0.263837209302 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| GRB2 | GAREM2 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GLS2 | GRB2 | 0.974 | 0.2 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NKX2-5 | GRB2 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GRB2 | SPATA2L | 0.948 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| GRB2 | SPATA2 | 0.923 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| GAREM2 | OR6Q1 | 0.902 | bioplex3_WMM WMM_only | ||
| GRB2 | THEMIS | 0.901 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | SPATA2L | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | GAREM2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GAREM2 | SPATA2L | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | GAREM1 | 0.543 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | SPATA2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | CYLD | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GAREM1 | SPATA2L | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GRB2 | OR6Q1 | 0.377 | bioplex3_WMM WMM_only | ||
| CYLD | SPATA2 | 0.366 | 0.088 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| GAREM2 | SPATA2 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | C16orf96 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CYLD | GAREM2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SPATA2 | SPATA2L | 0.287 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CYLD | GAREM1 | 0.191 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CYLD | SPATA2L | 0.173 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| NKX2-5 | SPATA2L | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | GAREM2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | CYLD | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GAREM1 | SPATA2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | SPATA2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | GAREM1 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf96 | GLS2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GLS2 | GAREM2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GLS2 | SPATA2L | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GLS2 | CYLD | 0.11 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| GLS2 | SPATA2 | 0.11 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| GLS2 | GAREM1 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NKX2-5 | GLS2 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes