hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12680.1
Complex Portal: CPX-22476
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BIRC2 | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | 5 | UniProt NCBI |
| CXCL2 | C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)] | 5 | UniProt NCBI |
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| BCL10 | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | 5 | UniProt NCBI |
| CXCL3 | C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)] | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TBK1 | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
| TBKBP1 | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | 5 | UniProt NCBI |
| AZI2 | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5212 | 3.09060412403e-13 | 0.454545454545 | TBKBP1 AZI2 TBK1 TANK TRAF2 | Kinase maturation complex 2 |
| WP:WP3865 | 9.08268986423e-11 | 0.545454545455 | IKBKE AZI2 TANK TRAF2 TBKBP1 TBK1 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04621 | 1.39758954302e-10 | 0.636363636364 | BIRC2 TANK TBK1 TRAF2 IKBKE BIRC3 CXCL1 | NOD-like receptor signaling pathway |
| KEGG:04622 | 1.41375041193e-10 | 0.545454545455 | IKBKE AZI2 TANK TRAF2 TBKBP1 TBK1 | RIG-I-like receptor signaling pathway |
| GO:0007249 | 1.71446446889e-10 | 0.818181818182 | BCL10 AZI2 TANK BIRC3 TRAF2 IKBKE TBKBP1 TBK1 BIRC2 | canonical NF-kappaB signal transduction |
| REAC:R-HSA-5357786 | 9.10213195565e-10 | 0.454545454545 | IKBKE TBK1 TRAF2 BIRC2 BIRC3 | TNFR1-induced proapoptotic signaling |
| WP:WP231 | 1.41691231435e-09 | 0.545454545455 | DIABLO TANK BIRC3 TRAF2 TBK1 BIRC2 | TNF alpha signaling pathway |
| GO:0019221 | 3.61991067186e-09 | 0.818181818182 | BIRC2 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 CXCL1 | cytokine-mediated signaling pathway |
| REAC:R-HSA-168164 | 5.75474743184e-09 | 0.545454545455 | IKBKE TANK BIRC3 TRAF2 TBK1 BIRC2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 6.57693145155e-09 | 0.545454545455 | IKBKE TANK BIRC3 TRAF2 TBK1 BIRC2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 6.57693145155e-09 | 0.545454545455 | IKBKE TANK BIRC3 TRAF2 TBK1 BIRC2 | TRIF(TICAM1)-mediated TLR4 signaling |
| GO:0140546 | 1.69139743615e-08 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | defense response to symbiont |
| REAC:R-HSA-5357905 | 2.30977198348e-08 | 0.454545454545 | IKBKE TBK1 TRAF2 BIRC2 BIRC3 | Regulation of TNFR1 signaling |
| GO:0098542 | 3.62492166295e-08 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | defense response to other organism |
| REAC:R-HSA-166016 | 3.63423327875e-08 | 0.545454545455 | IKBKE TANK BIRC3 TRAF2 TBK1 BIRC2 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0071345 | 4.14189207892e-08 | 0.818181818182 | BIRC2 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 CXCL1 | cellular response to cytokine stimulus |
| REAC:R-HSA-75893 | 6.08456596542e-08 | 0.454545454545 | IKBKE TBK1 TRAF2 BIRC2 BIRC3 | TNF signaling |
| REAC:R-HSA-168898 | 8.70090971319e-08 | 0.545454545455 | IKBKE TANK BIRC3 TRAF2 TBK1 BIRC2 | Toll-like Receptor Cascades |
| KEGG:04064 | 9.93556935177e-08 | 0.454545454545 | BIRC3 BCL10 TRAF2 BIRC2 CXCL1 | NF-kappa B signaling pathway |
| GO:0034097 | 1.19859224345e-07 | 0.818181818182 | BIRC2 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 CXCL1 | response to cytokine |
| GO:0051707 | 2.0211293872e-07 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to other organism |
| GO:0043207 | 2.0211293872e-07 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to external biotic stimulus |
| GO:0009607 | 2.80189395423e-07 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to biotic stimulus |
| GO:0045087 | 3.71155630723e-07 | 0.818181818182 | BCL10 AZI2 TANK BIRC3 TRAF2 IKBKE TBKBP1 TBK1 BIRC2 | innate immune response |
| GO:0044419 | 7.48241321252e-07 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | biological process involved in interspecies interaction between organisms |
| REAC:R-HSA-933541 | 1.05837268955e-06 | 0.363636363636 | IKBKE TBK1 TANK TRAF2 | TRAF6 mediated IRF7 activation |
| GO:0006952 | 1.30397617097e-06 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | defense response |
| GO:0006955 | 1.50927380659e-06 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | immune response |
| GO:0043122 | 1.98769337538e-06 | 0.636363636364 | BCL10 TANK BIRC3 TRAF2 IKBKE TBK1 BIRC2 | regulation of canonical NF-kappaB signal transduction |
| GO:0071310 | 2.72665564258e-06 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | cellular response to organic substance |
| GO:0007166 | 2.82336343885e-06 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | cell surface receptor signaling pathway |
| WP:WP5039 | 4.81805841172e-06 | 0.363636363636 | TBK1 TRAF2 CXCL1 TANK | SARS CoV 2 innate immunity evasion and cell specific immune response |
| GO:0035556 | 4.99414580905e-06 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | intracellular signal transduction |
| REAC:R-HSA-73887 | 5.25507810867e-06 | 0.454545454545 | IKBKE TBK1 TRAF2 BIRC2 BIRC3 | Death Receptor Signaling |
| KEGG:05417 | 5.9450002243e-06 | 0.454545454545 | IKBKE TBK1 TRAF2 CXCL1 TANK | Lipid and atherosclerosis |
| REAC:R-HSA-168249 | 6.53504346773e-06 | 0.727272727273 | BCL10 CXCL1 TANK TBK1 TRAF2 IKBKE BIRC3 BIRC2 | Innate Immune System |
| KEGG:04657 | 1.16472627601e-05 | 0.363636363636 | IKBKE TBK1 CXCL1 TRAF2 | IL-17 signaling pathway |
| REAC:R-HSA-5676594 | 1.35144212718e-05 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| REAC:R-HSA-9013973 | 1.80118276628e-05 | 0.272727272727 | IKBKE TANK TBK1 | TICAM1-dependent activation of IRF3/IRF7 |
| WP:WP254 | 1.92149687159e-05 | 0.363636363636 | TRAF2 DIABLO BIRC2 BIRC3 | Apoptosis |
| KEGG:04668 | 2.72108455765e-05 | 0.363636363636 | BIRC3 TRAF2 BIRC2 CXCL1 | TNF signaling pathway |
| GO:0010033 | 2.95639491954e-05 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to organic substance |
| REAC:R-HSA-936964 | 2.97769120821e-05 | 0.272727272727 | IKBKE TANK TBK1 | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| GO:0060337 | 3.10831691296e-05 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | type I interferon-mediated signaling pathway |
| GO:0071357 | 3.36618758141e-05 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | cellular response to type I interferon |
| CORUM:5529 | 3.41979277617e-05 | 0.181818181818 | BIRC2 TRAF2 | TRAF2-cIAP1/BIRC2 complex |
| GO:0043123 | 4.01731520286e-05 | 0.545454545455 | IKBKE BIRC2 BIRC3 TRAF2 TBK1 BCL10 | positive regulation of canonical NF-kappaB signal transduction |
| GO:0034340 | 4.9239332795e-05 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | response to type I interferon |
| REAC:R-HSA-168928 | 5.32133449591e-05 | 0.363636363636 | IKBKE TBK1 TANK TRAF2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:04215 | 5.84464711751e-05 | 0.272727272727 | DIABLO BIRC2 BIRC3 | Apoptosis - multiple species |
| GO:0009605 | 5.89464297043e-05 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to external stimulus |
| GO:0002376 | 6.77324503617e-05 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | immune system process |
| KEGG:04210 | 6.95402311979e-05 | 0.363636363636 | TRAF2 DIABLO BIRC2 BIRC3 | Apoptosis |
| GO:0070887 | 9.41592664541e-05 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | cellular response to chemical stimulus |
| CORUM:5531 | 0.000102551658964 | 0.181818181818 | BIRC2 TRAF2 | Tumor necrosis factor receptor 1 signaling complex |
| CORUM:5210 | 0.000102551658964 | 0.181818181818 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| GO:0140888 | 0.000132762329694 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | interferon-mediated signaling pathway |
| KEGG:05168 | 0.00020202368473 | 0.454545454545 | IKBKE TBK1 TRAF2 BIRC2 BIRC3 | Herpes simplex virus 1 infection |
| WP:WP2036 | 0.000233223279539 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| KEGG:05167 | 0.000266085200407 | 0.363636363636 | IKBKE TBK1 CXCL1 TRAF2 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-5675482 | 0.000329950651236 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.000329950651236 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | RIPK1-mediated regulated necrosis |
| GO:0141124 | 0.000389588707392 | 0.818181818182 | BCL10 AZI2 TANK BIRC3 TRAF2 IKBKE TBKBP1 TBK1 BIRC2 | intracellular signaling cassette |
| REAC:R-HSA-5357956 | 0.000402761203913 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168256 | 0.000961215599937 | 0.727272727273 | BCL10 CXCL1 TANK TBK1 TRAF2 IKBKE BIRC3 BIRC2 | Immune System |
| GO:1902554 | 0.000974635288956 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | serine/threonine protein kinase complex |
| GO:0042221 | 0.0010618254138 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to chemical |
| WP:WP5116 | 0.00150157543445 | 0.181818181818 | TBK1 IKBKE | SARS CoV 2 B 1 1 7 variant antagonises innate immune activation |
| KEGG:05222 | 0.00159901769094 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Small cell lung cancer |
| GO:1902911 | 0.0018421209374 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | protein kinase complex |
| REAC:R-HSA-5218859 | 0.00188588147319 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Regulated Necrosis |
| REAC:R-HSA-5357801 | 0.00239247956065 | 0.363636363636 | TRAF2 DIABLO BIRC2 BIRC3 | Programmed Cell Death |
| WP:WP1772 | 0.00244241245733 | 0.272727272727 | DIABLO BIRC2 BIRC3 | Apoptosis modulation and signaling |
| GO:0035631 | 0.00260828330546 | 0.272727272727 | TRAF2 BIRC2 DIABLO | CD40 receptor complex |
| HP:0012123 | 0.00285887750413 | 0.181818181818 | BIRC3 BCL10 | Posterior uveitis |
| CORUM:6344 | 0.00309671275823 | 0.181818181818 | BIRC3 TRAF2 | TNF-R1-associated signaling complex |
| WP:WP4658 | 0.00362949085424 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Small cell lung cancer |
| KEGG:04936 | 0.00477030981171 | 0.272727272727 | IKBKE CXCL1 TBK1 | Alcoholic liver disease |
| WP:WP5182 | 0.00486811003538 | 0.181818181818 | BIRC3 TRAF2 | Pro survival signaling of neuroprotectin D1 |
| KEGG:05160 | 0.00561579887786 | 0.272727272727 | IKBKE TRAF2 TBK1 | Hepatitis C |
| KEGG:04217 | 0.00641396286278 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Necroptosis |
| GO:0051607 | 0.00705561554422 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | defense response to virus |
| REAC:R-HSA-5668541 | 0.00812764950682 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | TNFR2 non-canonical NF-kB pathway |
| WP:WP4961 | 0.00817141007079 | 0.181818181818 | TBK1 IKBKE | STING pathway in Kawasaki like disease and COVID 19 |
| GO:0052547 | 0.00825937152553 | 0.454545454545 | BCL10 TANK DIABLO BIRC2 BIRC3 | regulation of peptidase activity |
| GO:0006950 | 0.00911090214581 | 0.909090909091 | BCL10 CXCL1 AZI2 TANK TBK1 TRAF2 IKBKE TBKBP1 BIRC3 BIRC2 | response to stress |
| GO:0007165 | 0.00965007681118 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | signal transduction |
| REAC:R-HSA-1280215 | 0.011999584092 | 0.454545454545 | BIRC3 TBK1 TRAF2 BIRC2 CXCL1 | Cytokine Signaling in Immune system |
| REAC:R-HSA-918233 | 0.0120819933003 | 0.181818181818 | TBK1 IKBKE | TRAF3-dependent IRF activation pathway |
| WP:WP4868 | 0.0134844837028 | 0.181818181818 | TBK1 IKBKE | Type I interferon induction and signaling during SARS CoV 2 infection |
| WP:000000 | 0.0140861908637 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | WIKIPATHWAYS |
| KEGG:05169 | 0.0143673531944 | 0.272727272727 | IKBKE TRAF2 TBK1 | Epstein-Barr virus infection |
| WP:WP3851 | 0.0159763787346 | 0.181818181818 | TBK1 IKBKE | TLR4 signaling and tolerance |
| WP:WP3858 | 0.0186770164082 | 0.181818181818 | TBK1 IKBKE | Toll like receptor signaling related to MyD88 |
| WP:WP4880 | 0.0215858775392 | 0.181818181818 | TBK1 IKBKE | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP5038 | 0.0215858775392 | 0.181818181818 | TBK1 IKBKE | Mitochondrial immune response to SARS CoV 2 |
| REAC:R-HSA-168927 | 0.022656954619 | 0.181818181818 | BIRC2 BIRC3 | TICAM1, RIP1-mediated IKK complex recruitment |
| GO:0023052 | 0.0231064767128 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | signaling |
| WP:WP3617 | 0.0231182298902 | 0.181818181818 | BIRC2 BIRC3 | Photodynamic therapy induced NF kB survival signaling |
| WP:WP4912 | 0.0231182298902 | 0.181818181818 | TBK1 IKBKE | SARS coronavirus and innate immunity |
| REAC:R-HSA-937041 | 0.0251640576042 | 0.181818181818 | BIRC2 BIRC3 | IKK complex recruitment mediated by RIP1 |
| WP:WP5115 | 0.0252993422133 | 0.272727272727 | TBK1 CXCL1 TRAF2 | Network map of SARS CoV 2 signaling pathway |
| GO:0050778 | 0.0259656973134 | 0.545454545455 | IKBKE BIRC2 BIRC3 TRAF2 TBK1 BCL10 | positive regulation of immune response |
| GO:0007154 | 0.0264536806263 | 1.0 | BCL10 BIRC2 AZI2 TANK TBK1 CXCL1 IKBKE TBKBP1 TRAF2 BIRC3 DIABLO | cell communication |
| KEGG:05132 | 0.0272801590691 | 0.272727272727 | TRAF2 BIRC2 BIRC3 | Salmonella infection |
| KEGG:05131 | 0.0283608704371 | 0.272727272727 | TBK1 BCL10 TRAF2 | Shigellosis |
| GO:0045089 | 0.0287221375648 | 0.454545454545 | IKBKE BCL10 TBK1 BIRC2 BIRC3 | positive regulation of innate immune response |
| GO:0002833 | 0.0413919622698 | 0.454545454545 | IKBKE BCL10 TBK1 BIRC2 BIRC3 | positive regulation of response to biotic stimulus |
| GO:1903322 | 0.0430720305378 | 0.363636363636 | BCL10 TANK BIRC2 BIRC3 | positive regulation of protein modification by small protein conjugation or removal |
| GO:1901875 | 0.0447114312631 | 0.363636363636 | BCL10 TANK BIRC2 BIRC3 | positive regulation of post-translational protein modification |
| GO:0051247 | 0.0479732078894 | 0.636363636364 | BCL10 BIRC2 TANK TBK1 TRAF2 BIRC3 DIABLO | positive regulation of protein metabolic process |
| GO:0061695 | 0.0487625050341 | 0.454545454545 | IKBKE TBKBP1 AZI2 TANK TBK1 | transferase complex, transferring phosphorus-containing groups |
| CORUM:2052 | 0.049976851631 | 0.0909090909091 | BCL10 | BCL10 homo-oligomer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BIRC2 | DIABLO | 1.0 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC2 | TRAF2 | 0.999 | 0.2272 |
mutually_exclusive (Q13077)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TBK1 | 0.998 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| TRAF2 | TBK1 | 0.998 | 0.06 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| CXCL3 | CXCL2 | 0.998 |
mutually_exclusive (P09341)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRAF2 | DIABLO | 0.996 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BIRC3 | BCL10 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC2 | CXCL1 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TANK | DIABLO | 0.993 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AZI2 | TBK1 | 0.99 | 0.12 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CXCL1 | TBK1 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CXCL3 | CXCL1 | 0.972 |
mutually_exclusive (P19875)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BIRC3 | TRAF2 | 0.969 |
mutually_exclusive (Q9NR28)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | DIABLO | 0.964 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC2 | TANK | 0.955 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CXCL1 | DIABLO | 0.952 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC2 | TBK1 | 0.939 | 0.184 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CXCL3 | TRAF2 | 0.928 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BCL10 | TRAF2 | 0.917 | 0.048 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CXCL1 | CXCL2 | 0.894 |
mutually_exclusive (P19876)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | ||
| AZI2 | TANK | 0.874 | 0.162 | bioplex_WMM bioplex3_WMM WMM_only | |
| TBK1 | DIABLO | 0.858 | 0.052 | youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| TBK1 | TBKBP1 | 0.85 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM WMM_only boldt_WMM | ||
| BIRC2 | CXCL3 | 0.797 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC2 | IKBKE | 0.492 | bioplex3_WMM WMM_only | ||
| IKBKE | TBK1 | 0.456 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| BIRC2 | BIRC3 | 0.438 | bioplex3_WMM WMM_only | ||
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | ||
| IKBKE | DIABLO | 0.374 | bioplex3_WMM WMM_only | ||
| BIRC3 | TBK1 | 0.373 | bioplex3_WMM WMM_only | ||
| AZI2 | TBKBP1 | 0.371 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| TRAF2 | CXCL2 | 0.334 | bioplex3_WMM WMM_only | ||
| BIRC2 | BCL10 | 0.228 | 0.082 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BIRC2 | CXCL2 | 0.105 | bioplex3_WMM WMM_only | ||
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAF2 | TBKBP1 | 0.022 | youn_WMM WMM_only | ||
| AZI2 | DIABLO | 0.022 | 0.102 | youn_WMM WMM_only | |
| DIABLO | TBKBP1 | 0.015 | youn_WMM WMM_only | ||
| AZI2 | TRAF2 | 0.014 | 0.158 | youn_WMM WMM_only | |
| BCL10 | TBK1 | 0.008 | 0.058 |
structurally_consistent (Q14164)
|
gupta_WMM WMM_only |
Related Complexes