hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12692.1
Complex Portal: CPX-11353
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TIMP2 | Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) | 5 | UniProt NCBI |
| MMP2 | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5097 | 0.0136300504448 | 1.0 | MMP2 | CCL18 signaling pathway |
| CORUM:2798 | 0.0249718442455 | 1.0 | MMP2 | MMP-2-CLDN1 complex |
| HP:0006012 | 0.0495817777049 | 1.0 | MMP2 | Widened metacarpal shaft |
| HP:0008078 | 0.0495817777049 | 1.0 | MMP2 | Thin metatarsal cortices |
| HP:0008090 | 0.0495817777049 | 1.0 | MMP2 | Ankylosis of feet small joints |
| HP:0008133 | 0.0495817777049 | 1.0 | MMP2 | Distal tapering of metatarsals |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TIMP2 | MMP2 | 0.971 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| TIMP2 | huMAP3_01505.1 huMAP3_11842.1 huMAP3_12426.1 huMAP3_12692.1 |
| MMP2 | huMAP3_01505.1 huMAP3_12426.1 huMAP3_12692.1 |