hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12703.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HYAL4 | Hyaluronidase-4 (Hyal-4) (EC 3.2.1.35) (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin sulfate hydrolase) (CSHY) (Hyaluronoglucosaminidase-4) | 5 | UniProt NCBI |
| MUSK | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | 5 | UniProt NCBI |
| SPCS2 | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | 5 | UniProt NCBI |
| PVRIG | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | 5 | UniProt NCBI |
| RTN4R | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) | 5 | UniProt NCBI |
| ADAM30 | Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-) | 5 | UniProt NCBI |
| WNT6 | Protein Wnt-6 | 5 | UniProt NCBI |
| SEC11C | Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) | 5 | UniProt NCBI |
| TREM1 | Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354) | 5 | UniProt NCBI |
| SPCS3 | Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit) | 5 | UniProt NCBI |
| HES1 | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | 5 | UniProt NCBI |
| FBXL14 | F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14) | 5 | UniProt NCBI |
| CHRNE | Acetylcholine receptor subunit epsilon | 5 | UniProt NCBI |
| ALPL | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1) | 5 | UniProt NCBI |
| SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) | 5 | UniProt NCBI |
| SEC11A | Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) | 5 | UniProt NCBI |
| TNFRSF10D | Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005787 | 5.57191707223e-11 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | signal peptidase complex |
| REAC:R-HSA-400511 | 1.65398126608e-10 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| REAC:R-HSA-422085 | 4.6012124482e-10 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Synthesis, secretion, and deacylation of Ghrelin |
| REAC:R-HSA-381771 | 2.20624715025e-09 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| REAC:R-HSA-400508 | 4.1401289581e-09 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Incretin synthesis, secretion, and inactivation |
| KEGG:03060 | 9.41555169747e-09 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Protein export |
| GO:0006465 | 7.13187929471e-08 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | signal peptide processing |
| REAC:R-HSA-2980736 | 3.08106579666e-06 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Peptide hormone metabolism |
| WP:WP5408 | 5.01702649393e-06 | 0.235294117647 | SPCS2 SEC11A SPCS3 SPCS1 | 15q25 copy number variation |
| REAC:R-HSA-1799339 | 4.09390789416e-05 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | SRP-dependent cotranslational protein targeting to membrane |
| GO:1905368 | 0.0039303078488 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | peptidase complex |
| REAC:R-HSA-72766 | 0.0047171579261 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | Translation |
| GO:0140534 | 0.00502355672909 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | endoplasmic reticulum protein-containing complex |
| GO:0016485 | 0.0423832902014 | 0.294117647059 | SEC11A SPCS2 SPCS1 SEC11C SPCS3 | protein processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| SPCS2 | SPCS3 | 1.0 | 0.946 |
| SPCS3 | SEC11A | 1.0 | 0.928 |
| SPCS1 | SEC11C | 1.0 | 0.054 |
| SPCS2 | SEC11C | 0.999 | 0.212 |
| SEC11C | SPCS3 | 0.999 | 0.138 |
| SPCS1 | SPCS3 | 0.998 | 0.822 |
| SPCS1 | SPCS2 | 0.997 | 0.646 |
| SPCS1 | SEC11A | 0.997 | 0.606 |
| SPCS1 | PVRIG | 0.996 | |
| MUSK | ADAM30 | 0.996 | |
| PVRIG | SPCS2 | 0.996 | |
| SPCS2 | SEC11A | 0.995 | 0.9 |
| SPCS1 | ADAM30 | 0.994 | |
| SPCS2 | FBXL14 | 0.994 | |
| SPCS1 | RTN4R | 0.993 | |
| SPCS2 | ADAM30 | 0.993 | |
| SPCS1 | TREM1 | 0.991 | |
| TREM1 | SPCS2 | 0.983 | |
| RTN4R | SPCS2 | 0.98 | |
| SEC11C | SEC11A | 0.973 | 0.17 |
| SEC11C | WNT6 | 0.95 | |
| FBXL14 | HES1 | 0.946 | |
| SEC11C | ADAM30 | 0.937 | |
| SEC11C | CHRNE | 0.919 | |
| PVRIG | SPCS3 | 0.91 | |
| RTN4R | SEC11A | 0.903 | |
| SPCS1 | FBXL14 | 0.902 | |
| TNFRSF10D | RTN4R | 0.902 | |
| TREM1 | SEC11A | 0.898 | |
| TREM1 | SPCS3 | 0.893 | |
| PVRIG | SEC11A | 0.839 | |
| SPCS1 | HYAL4 | 0.83 | |
| SEC11A | FBXL14 | 0.829 | |
| SPCS1 | ALPL | 0.82 | 0.024 |
| SPCS3 | ADAM30 | 0.819 | |
| RTN4R | SPCS3 | 0.817 | |
| SPCS3 | FBXL14 | 0.805 | |
| SEC11A | ADAM30 | 0.748 | |
| SPCS2 | WNT6 | 0.733 | |
| SEC11A | ALPL | 0.719 | 0.038 |
| SPCS1 | WNT6 | 0.698 | |
| SPCS2 | ALPL | 0.599 | 0.092 |
| SPCS3 | ALPL | 0.406 | 0.068 |
| SEC11C | ALPL | 0.347 | 0.048 |
| SEC11C | FBXL14 | 0.333 | |
| SPCS2 | HYAL4 | 0.287 | |
| SEC11A | WNT6 | 0.23 | |
| SPCS3 | WNT6 | 0.103 | |
| SEC11A | HYAL4 | 0.102 | |
| SEC11A | CHRNE | 0.039 | |
| SPCS3 | CHRNE | 0.021 | |
| SPCS3 | HYAL4 | 0.017 | |
| SPCS2 | CHRNE | 0.015 | |
| TNFRSF10D | SPCS3 | 0.009 | 0.064 |
Related Complexes