hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12712.1
Complex Portal: CPX-12763
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC9A5 | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | 5 | UniProt NCBI |
| DIRAS2 | GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) | 4 | UniProt NCBI |
| UNC13A | Protein unc-13 homolog A (Munc13-1) | 5 | UniProt NCBI |
| TOP1MT | DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) | 5 | UniProt NCBI |
| UNC13B | Protein unc-13 homolog B (Munc13-2) (munc13) | 5 | UniProt NCBI |
| RAP1GDS1 | Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) | 5 | UniProt NCBI |
| DIRAS1 | GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061789 | 0.00983221512175 | 0.285714285714 | UNC13A UNC13B | dense core granule priming |
| GO:0099011 | 0.00983221512175 | 0.285714285714 | UNC13A UNC13B | neuronal dense core vesicle exocytosis |
| GO:0099525 | 0.00983221512175 | 0.285714285714 | UNC13A UNC13B | presynaptic dense core vesicle exocytosis |
| GO:1990504 | 0.00983221512175 | 0.285714285714 | UNC13A UNC13B | dense core granule exocytosis |
| WP:WP2267 | 0.0159344117177 | 0.285714285714 | UNC13A UNC13B | Synaptic vesicle pathway |
| KEGG:04721 | 0.0179270542228 | 0.285714285714 | UNC13A UNC13B | Synaptic vesicle cycle |
| WP:WP4949 | 0.0435709553271 | 0.285714285714 | UNC13A UNC13B | 16p11 2 proximal deletion syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAP1GDS1 | DIRAS1 | 1.0 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAP1GDS1 | DIRAS2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC9A5 | DIRAS1 | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UNC13B | DIRAS1 | 0.982 | 0.114 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DIRAS2 | DIRAS1 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DIRAS2 | UNC13B | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RAP1GDS1 | TOP1MT | 0.883 | 0.12 | hein_WMM bioplex3_WMM WMM_only | |
| DIRAS1 | UNC13A | 0.816 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAP1GDS1 | UNC13B | 0.418 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAP1GDS1 | SLC9A5 | 0.324 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UNC13B | UNC13A | 0.25 | bioplex3_WMM WMM_only | ||
| RAP1GDS1 | UNC13A | 0.089 | bioplex3_WMM WMM_only |
Related Complexes