hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12714.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDY2A | Testis-specific chromodomain protein Y 2 (EC 2.3.1.48) | 3 | UniProt NCBI |
| HSF2BP | Heat shock factor 2-binding protein | 5 | UniProt NCBI |
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | 5 | UniProt NCBI |
| ATF7IP2 | Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2) | 4 | UniProt NCBI |
| STRA6 | Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) | 5 | UniProt NCBI |
| ARL14EP | ARL14 effector protein (ARF7 effector protein) | 5 | UniProt NCBI |
| ATF7IP | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | 5 | UniProt NCBI |
| PRC1 | Protein regulator of cytokinesis 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2238 | 2.05265451394e-05 | 0.285714285714 | ATF7IP SETDB1 | MBD1-MCAF1-SETDB1 complex |
| CORUM:2749 | 2.05265451394e-05 | 0.285714285714 | ATF7IP SETDB1 | SETDB1-containing HMTase complex |
| GO:0090309 | 0.00040312426486 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | positive regulation of DNA methylation-dependent heterochromatin formation |
| GO:0031453 | 0.000738757615619 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | positive regulation of heterochromatin formation |
| GO:0120263 | 0.000738757615619 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | positive regulation of heterochromatin organization |
| GO:1905269 | 0.000960187650128 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | positive regulation of chromatin organization |
| GO:0090308 | 0.00122180600483 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | regulation of DNA methylation-dependent heterochromatin formation |
| GO:0031445 | 0.0032492156641 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | regulation of heterochromatin formation |
| GO:0120261 | 0.0032492156641 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | regulation of heterochromatin organization |
| GO:0006346 | 0.00593357407009 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | DNA methylation-dependent heterochromatin formation |
| GO:0140718 | 0.0150353457168 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | facultative heterochromatin formation |
| GO:1902275 | 0.0150353457168 | 0.428571428571 | ATF7IP2 SETDB1 ATF7IP | regulation of chromatin organization |
| HPA:0570781 | 0.0284194718187 | 0.714285714286 | PRC1 HSF2BP ATF7IP ARL14EP ATF7IP2 | testis; preleptotene spermatocytes[>=Low] |
| CORUM:2759 | 0.0499958217778 | 0.142857142857 | ATF7IP | MBD1-MCAF complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SETDB1 | ATF7IP | 1.0 | 0.474 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () Malo fraction |
| SETDB1 | ARL14EP | 1.0 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| ATF7IP | ARL14EP | 0.986 | 0.188 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| STRA6 | ATF7IP2 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HSF2BP | SETDB1 | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HSF2BP | ARL14EP | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF7IP2 | SETDB1 | 0.956 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HSF2BP | PRC1 | 0.949 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF7IP2 | ARL14EP | 0.949 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF7IP | CDY2A | 0.881 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SETDB1 | CDY2A | 0.8 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF7IP2 | ATF7IP | 0.335 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| STRA6 | ARL14EP | 0.113 | 0.086 | bioplex3_WMM WMM_only |
| PRC1 | SETDB1 | 0.11 | 0.06 | bioplex3_WMM WMM_only |
| PRC1 | ARL14EP | 0.089 | 0.046 | bioplex3_WMM WMM_only |
| STRA6 | SETDB1 | 0.078 | 0.08 | bioplex3_WMM WMM_only |
| STRA6 | ATF7IP | 0.076 | 0.07 | bioplex3_WMM WMM_only |
| PRC1 | ATF7IP | 0.015 | 0.044 | youn_WMM WMM_only |
Related Complexes