hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12717.1
Complex Portal: CPX-25676
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBOX5 | RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) | 5 | UniProt NCBI |
| TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | 5 | UniProt NCBI |
| ABL1 | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | 5 | UniProt NCBI |
| TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | 5 | UniProt NCBI |
| EMILIN1 | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | 5 | UniProt NCBI |
| TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | 5 | UniProt NCBI |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5268 | 1.34496026232e-10 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TNF-alpha/NF-kappa B signaling complex 7 |
| REAC:R-HSA-937042 | 7.48865454753e-10 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-9014325 | 1.17659521447e-09 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| REAC:R-HSA-9645460 | 1.17659521447e-09 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Alpha-protein kinase 1 signaling pathway |
| REAC:R-HSA-975163 | 2.5484518932e-09 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-937072 | 2.5484518932e-09 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| CORUM:2758 | 7.02338504734e-09 | 0.428571428571 | TAB1 TAB2 MAP3K7 | TAK1 complex |
| REAC:R-HSA-450321 | 8.47738354883e-09 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 1.72490220596e-08 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-5357956 | 1.277713074e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TNFR1-induced NF-kappa-B signaling pathway |
| REAC:R-HSA-168638 | 1.277713074e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | NOD1/2 Signaling Pathway |
| KEGG:05130 | 1.85789301391e-07 | 0.714285714286 | TAB1 TAB3 TAB2 MAP3K7 ABL1 | Pathogenic Escherichia coli infection |
| WP:WP2637 | 2.04577827115e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-445989 | 2.09160668344e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TAK1-dependent IKK and NF-kappa-B activation |
| WP:WP195 | 3.22291578791e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | IL 1 signaling pathway |
| REAC:R-HSA-168643 | 5.78486671794e-07 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| REAC:R-HSA-75893 | 1.03686148446e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TNF signaling |
| REAC:R-HSA-450294 | 1.29989157009e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | MAP kinase activation |
| KEGG:04064 | 1.50150118715e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | NF-kappa B signaling pathway |
| REAC:R-HSA-448424 | 1.97234251471e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Interleukin-17 signaling |
| CORUM:6344 | 2.55074322511e-06 | 0.428571428571 | TAB1 TAB2 MAP3K7 | TNF-R1-associated signaling complex |
| KEGG:04668 | 3.01488595818e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TNF signaling pathway |
| WP:WP75 | 3.02622905587e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll like receptor signaling pathway |
| WP:WP231 | 3.17701648977e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TNF alpha signaling pathway |
| REAC:R-HSA-2871837 | 4.28820405091e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | FCERI mediated NF-kB activation |
| REAC:R-HSA-975871 | 6.16370423158e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 6.16370423158e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 6.16370423158e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 6.79733760602e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 7.13183221125e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 7.13183221125e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 8.59438461413e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 9 (TLR9) Cascade |
| KEGG:04936 | 8.84180128664e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Alcoholic liver disease |
| REAC:R-HSA-5607764 | 8.99263973412e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-168164 | 9.40454269709e-06 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 1.02705207546e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 1.02705207546e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 1.11948091005e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 1.11948091005e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-181438 | 1.21799509581e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 1.21799509581e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-9020702 | 1.32285423695e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Interleukin-1 signaling |
| WP:WP3851 | 1.39543003397e-05 | 0.428571428571 | TAB1 TAB2 MAP3K7 | TLR4 signaling and tolerance |
| KEGG:04621 | 1.70572201178e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | NOD-like receptor signaling pathway |
| REAC:R-HSA-2454202 | 2.10045421187e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-9705671 | 2.177889083e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| WP:WP4329 | 2.72379451391e-05 | 0.428571428571 | TAB1 TAB2 MAP3K7 | miRNA role in immune response in sepsis |
| REAC:R-HSA-5621481 | 2.87672068396e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | C-type lectin receptors (CLRs) |
| REAC:R-HSA-166016 | 3.17773652341e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 3.61497405074e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Death Receptor Signaling |
| REAC:R-HSA-446652 | 3.84972396515e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Interleukin-1 family signaling |
| REAC:R-HSA-168898 | 5.66464039369e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Toll-like Receptor Cascades |
| CORUM:5215 | 6.1565588648e-05 | 0.285714285714 | TAB1 TAB2 | CS-MAP3K7IP1-MAP3K7IP2 complex |
| WP:WP2018 | 9.17015920136e-05 | 0.428571428571 | TAB1 TAB2 MAP3K7 | RANKL RANK signaling pathway |
| KEGG:05132 | 9.46610713966e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Salmonella infection |
| KEGG:05131 | 9.98209485344e-05 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Shigellosis |
| KEGG:05140 | 0.000131211059871 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Leishmaniasis |
| REAC:R-HSA-9705683 | 0.00017454112665 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | SARS-CoV-2-host interactions |
| KEGG:04657 | 0.000253000862682 | 0.428571428571 | TAB3 TAB2 MAP3K7 | IL-17 signaling pathway |
| KEGG:04620 | 0.000365846097346 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Toll-like receptor signaling pathway |
| KEGG:05145 | 0.000418965008626 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Toxoplasmosis |
| REAC:R-HSA-9694516 | 0.000772937908588 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | SARS-CoV-2 Infection |
| KEGG:05135 | 0.000847297701863 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Yersinia infection |
| KEGG:04380 | 0.000847297701863 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Osteoclast differentiation |
| KEGG:05161 | 0.00180438218152 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Hepatitis B |
| WP:WP4666 | 0.00248543743158 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Hepatitis B infection |
| REAC:R-HSA-5663205 | 0.00262907091591 | 0.714285714286 | TAB1 TAB3 TAB2 MAP3K7 ABL1 | Infectious disease |
| REAC:R-HSA-9679506 | 0.0027504989814 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | SARS-CoV Infections |
| REAC:R-HSA-168256 | 0.00286965709282 | 0.857142857143 | TAB3 TAB2 TAB1 ABL1 UBOX5 MAP3K7 | Immune System |
| REAC:R-HSA-168249 | 0.00300736036824 | 0.714285714286 | TAB1 TAB3 TAB2 MAP3K7 ABL1 | Innate Immune System |
| KEGG:05169 | 0.0032364559788 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Epstein-Barr virus infection |
| KEGG:05417 | 0.0032364559788 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Lipid and atherosclerosis |
| REAC:R-HSA-449147 | 0.00337550181466 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Signaling by Interleukins |
| KEGG:05170 | 0.0039833462196 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Human immunodeficiency virus 1 infection |
| WP:WP4496 | 0.00769886208303 | 0.285714285714 | TAB1 MAP3K7 | Signal transduction through IL1R |
| WP:WP382 | 0.00780086249264 | 0.428571428571 | TAB1 TAB2 MAP3K7 | MAPK signaling pathway |
| KEGG:04010 | 0.00789399135774 | 0.428571428571 | TAB1 TAB2 MAP3K7 | MAPK signaling pathway |
| HP:0001679 | 0.00807643111384 | 0.571428571429 | ABL1 TAB2 MAP3K7 EMILIN1 | Abnormal aortic morphology |
| REAC:R-HSA-1280215 | 0.0183128073795 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Cytokine Signaling in Immune system |
| HP:0011004 | 0.0253027158062 | 0.571428571429 | ABL1 TAB2 MAP3K7 EMILIN1 | Abnormal systemic arterial morphology |
| GO:0042742 | 0.0260575019522 | 0.571428571429 | TAB3 TAB2 MAP3K7 EMILIN1 | defense response to bacterium |
| KEGG:05168 | 0.0266135315089 | 0.428571428571 | TAB1 TAB2 MAP3K7 | Herpes simplex virus 1 infection |
| HP:0001382 | 0.030987905771 | 0.571428571429 | ABL1 TAB2 MAP3K7 EMILIN1 | Joint hypermobility |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | TAB1 TAB2 MAP3K7 TAB3 | Viral Infection Pathways |
| HPA:0510000 | 0.0340880803824 | 1.0 | TAB3 TAB2 TAB1 ABL1 UBOX5 EMILIN1 MAP3K7 | soft tissue 2 |
| REAC:R-HSA-1643685 | 0.0367346572641 | 0.714285714286 | TAB1 TAB3 TAB2 MAP3K7 ABL1 | Disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TAB1 | TAB2 | 0.999 | 0.156 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| TAB1 | MAP3K7 | 0.999 | 0.266 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| TAB1 | TAB3 | 0.998 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| TAB2 | EMILIN1 | 0.998 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAB3 | EMILIN1 | 0.998 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAB1 | EMILIN1 | 0.996 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAP3K7 | EMILIN1 | 0.995 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UBOX5 | EMILIN1 | 0.991 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TAB2 | MAP3K7 | 0.982 | 0.428 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| TAB3 | TAB2 | 0.865 | 0.118 |
mutually_exclusive (O43318)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TAB3 | MAP3K7 | 0.848 | 0.142 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ABL1 | MAP3K7 | 0.822 | 0.082 | hein_WMM bioplex3_WMM WMM_only | |
| MAP3K7 | UBOX5 | 0.237 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| TAB2 | UBOX5 | 0.213 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| TAB3 | UBOX5 | 0.164 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| TAB1 | UBOX5 | 0.143 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| ABL1 | TAB2 | 0.081 | 0.146 | bioplex3_WMM WMM_only | |
| ABL1 | TAB3 | 0.076 | 0.088 | bioplex3_WMM WMM_only | |
| ABL1 | TAB1 | 0.027 | 0.132 | bioplex3_WMM WMM_only |
Related Complexes