hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12719.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FNIP1 | Folliculin-interacting protein 1 | 5 | UniProt NCBI |
| FNIP2 | Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) | 5 | UniProt NCBI |
| FLCN | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | 5 | UniProt NCBI |
| CPXCR1 | CPX chromosomal region candidate gene 1 protein (Cancer/testis antigen 77) (CT77) | 2 | UniProt NCBI |
| ZFYVE19 | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | 5 | UniProt NCBI |
| CHMP1B | Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2) | 5 | UniProt NCBI |
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7430 | 2.05265451394e-05 | 0.285714285714 | FNIP2 FLCN | FLCN-FNIP2 complex |
| REAC:R-HSA-9639288 | 0.00030234111687 | 0.428571428571 | FNIP1 FLCN FNIP2 | Amino acids regulate mTORC1 |
| KEGG:04150 | 0.00180438218152 | 0.428571428571 | FNIP1 FLCN FNIP2 | mTOR signaling pathway |
| WP:WP5381 | 0.00265193272199 | 0.428571428571 | FNIP1 FLCN FNIP2 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-9711097 | 0.00739955871017 | 0.428571428571 | FNIP1 FLCN FNIP2 | Cellular response to starvation |
| GO:1905672 | 0.0294899169624 | 0.285714285714 | FNIP1 FLCN | negative regulation of lysosome organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FNIP1 | FNIP2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VTA1 | CHMP1B | 0.994 | 0.052 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FNIP1 | VTA1 | 0.992 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FNIP2 | VTA1 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VTA1 | FLCN | 0.987 | 0.196 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CPXCR1 | VTA1 | 0.978 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VTA1 | ZFYVE19 | 0.947 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex_WMM WMM_only |
| ZFYVE19 | CHMP1B | 0.881 | 0.038 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| FNIP2 | FLCN | 0.789 | bioplex3_WMM WMM_only | |
| FNIP1 | FLCN | 0.72 | 0.16 | bioplex3_WMM WMM_only |
| FNIP1 | ZFYVE19 | 0.274 | 0.092 | bioplex3_WMM WMM_only |
| FNIP2 | ZFYVE19 | 0.146 | bioplex3_WMM WMM_only | |
| ZFYVE19 | FLCN | 0.076 | 0.162 | bioplex3_WMM WMM_only |
Related Complexes