hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12731.1
Complex Portal: CPX-15471
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | 5 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
| CLEC4G | C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin) | 5 | UniProt NCBI |
| KNDC1 | Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) | 5 | UniProt NCBI |
| AP4S1 | AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) | 5 | UniProt NCBI |
| TEPSIN | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | 5 | UniProt NCBI |
| AP4M1 | AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4) | 5 | UniProt NCBI |
| DISC1 | Disrupted in schizophrenia 1 protein | 5 | UniProt NCBI |
| AP4E1 | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | 5 | UniProt NCBI |
| AP4B1 | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:67 | 8.06664600281e-12 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | AP4 adaptor complex |
| GO:0030124 | 5.52565251192e-09 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | AP-4 adaptor complex |
| HP:5200020 | 2.27078705572e-08 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal interest in others |
| HP:0100962 | 2.27078705572e-08 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Shyness |
| HP:0008807 | 5.2218365052e-07 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Acetabular dysplasia |
| HP:0002464 | 6.44838333121e-07 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Spastic dysarthria |
| HP:0010803 | 7.87876631606e-07 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Everted upper lip vermilion |
| REAC:R-HSA-432720 | 1.081952275e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Lysosome Vesicle Biogenesis |
| HP:0007020 | 2.2009534238e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Progressive spastic paraplegia |
| HP:0002816 | 4.39145335146e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Genu recurvatum |
| HP:0002761 | 7.07849691944e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Generalized joint hypermobility |
| HP:0025502 | 7.07849691944e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Overweight |
| HP:0010500 | 7.90865853887e-06 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Hyperextensibility of the knee |
| HP:0000297 | 1.32006084854e-05 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Facial hypotonia |
| REAC:R-HSA-199992 | 2.39497785462e-05 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | trans-Golgi Network Vesicle Budding |
| CORUM:6046 | 3.07577115383e-05 | 0.2 | PDE4B DISC1 | PDE4B-DISC1 complex |
| KEGG:04142 | 4.85769358756e-05 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Lysosome |
| GO:0031904 | 8.20132428287e-05 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | endosome lumen |
| CORUM:7004 | 9.22394575203e-05 | 0.2 | PDE4B DISC1 | HTT-DISC1-PDE4B complex |
| GO:0032588 | 0.000102961120901 | 0.5 | TEPSIN AP4B1 AP4E1 AP4S1 AP4M1 | trans-Golgi network membrane |
| HP:0003170 | 0.000135750528456 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal acetabulum morphology |
| HP:0034670 | 0.000143141726215 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal knee physiology |
| GO:0030119 | 0.00028638924344 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | AP-type membrane coat adaptor complex |
| HP:0002307 | 0.00036408199252 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Drooling |
| HP:0000646 | 0.00039529603344 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Amblyopia |
| HP:0001258 | 0.000445805149957 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Spastic paraplegia |
| HP:0003781 | 0.00050097775484 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Excessive salivation |
| HP:0002515 | 0.000540485484732 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Waddling gait |
| HP:0002518 | 0.00110956983166 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal periventricular white matter morphology |
| HP:0010550 | 0.00110956983166 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Paraplegia |
| HP:0012433 | 0.00163393914039 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal social behavior |
| HP:0000341 | 0.0022055329013 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Narrow forehead |
| HP:0012472 | 0.00238436122066 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Eclabion |
| HP:0100755 | 0.00352636069499 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormality of salivation |
| HP:0000414 | 0.00360912699019 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Bulbous nose |
| HP:0002465 | 0.00360912699019 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Poor speech |
| HP:0010551 | 0.0055874801458 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Paraplegia/paraparesis |
| HP:0000154 | 0.0058219958417 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Wide mouth |
| HP:0002061 | 0.00683372601065 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Lower limb spasticity |
| HP:0000280 | 0.00767393593163 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Coarse facial features |
| HP:0002352 | 0.00812162374897 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Leukoencephalopathy |
| GO:0005802 | 0.00817366085861 | 0.5 | TEPSIN AP4B1 AP4E1 AP4S1 AP4M1 | trans-Golgi network |
| HP:0000322 | 0.0110340410051 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Short philtrum |
| GO:0030117 | 0.0119680463758 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | membrane coat |
| GO:0048475 | 0.0119680463758 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | coated membrane |
| HP:0000733 | 0.0137344865261 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal repetitive mannerisms |
| HP:0031432 | 0.0137344865261 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Restricted or repetitive behaviors or interests |
| HP:0031828 | 0.0174253077969 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal superficial reflex |
| HP:0003487 | 0.0174253077969 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Babinski sign |
| GO:0098791 | 0.0182422070876 | 0.5 | TEPSIN AP4B1 AP4E1 AP4S1 AP4M1 | Golgi apparatus subcompartment |
| HP:0002355 | 0.0185223003585 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Difficulty walking |
| HP:0031815 | 0.0244435495936 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal oral physiology |
| HP:0000301 | 0.0244435495936 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormality of facial musculature |
| HP:0002120 | 0.0346731090306 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Cerebral cortical atrophy |
| HP:0001763 | 0.0360285197373 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Pes planus |
| HP:0010864 | 0.0418434633702 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Intellectual disability, severe |
| HP:0007370 | 0.0433615565012 | 0.5 | AP4M1 AP4B1 AP4E1 AP4S1 DISC1 | Aplasia/Hypoplasia of the corpus callosum |
| HP:0001384 | 0.0444594373544 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal hip joint morphology |
| HP:0000436 | 0.0477551931661 | 0.4 | AP4M1 AP4B1 AP4S1 AP4E1 | Abnormal nasal tip morphology |
| HP:0002538 | 0.0478361722388 | 0.5 | AP4M1 AP4B1 AP4E1 AP4S1 DISC1 | Abnormal cerebral cortex morphology |
| CORUM:7235 | 0.0499436884912 | 0.1 | DISC1 | DISC1-DRD2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP4E1 | TEPSIN | 1.0 | 0.138 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4S1 | AP4B1 | 1.0 | 0.172 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4E1 | AP4B1 | 1.0 | 0.284 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4M1 | AP4E1 | 1.0 | 0.17 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4M1 | TEPSIN | 1.0 | 0.078 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4M1 | AP4B1 | 0.999 | 0.18 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| AP4S1 | AP4M1 | 0.999 | 0.112 |
mutually_exclusive (Q9Y6B7)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| AP4S1 | AP4E1 | 0.999 | 0.166342857143 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4B1 | TEPSIN | 0.998 | 0.172 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4S1 | TEPSIN | 0.998 | 0.126 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4S1 | DISC1 | 0.994 | 0.066 |
structurally_consistent (O00189)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4E1 | DISC1 | 0.993 | 0.154 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CLEC4G | TEPSIN | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PDE4B | DISC1 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AP4B1 | DISC1 | 0.978 | 0.134 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP4M1 | SUV39H2 | 0.943 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4E1 | SUV39H2 | 0.936 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4M1 | DISC1 | 0.925 | 0.122 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| KNDC1 | TEPSIN | 0.918 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AP4S1 | SUV39H2 | 0.914 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4E1 | PDE4B | 0.676 | bioplex3_WMM WMM_only | ||
| AP4S1 | PDE4B | 0.455 | bioplex3_WMM WMM_only | ||
| AP4B1 | CLEC4G | 0.415 | bioplex3_WMM WMM_only | ||
| AP4E1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4M1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4S1 | CLEC4G | 0.274 | bioplex3_WMM WMM_only | ||
| AP4B1 | PDE4B | 0.146 | bioplex3_WMM WMM_only | ||
| AP4M1 | PDE4B | 0.131 | bioplex3_WMM WMM_only |
Related Complexes