hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12733.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| NME8 | Thioredoxin domain-containing protein 3 (3'-5' exonuclease NME8) (EC 3.1.-.-) (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 5 | UniProt NCBI |
| RBM15B | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | 5 | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | 5 | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | 5 | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | 5 | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | 5 | UniProt NCBI |
| WAC | WW domain-containing adapter protein with coiled-coil | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 1.70069372575e-18 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 3.64471100416e-16 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | mRNA editing complex |
| GO:0080009 | 9.58591035825e-12 | 0.6 | METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | mRNA methylation |
| GO:0016556 | 2.91053289042e-10 | 0.6 | METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | mRNA modification |
| GO:0001510 | 5.54597880739e-10 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | RNA methylation |
| GO:0034708 | 1.69513769232e-09 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | methyltransferase complex |
| GO:0043414 | 1.96647163615e-08 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | macromolecule methylation |
| GO:0032259 | 2.58557647889e-08 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | methylation |
| GO:0009451 | 7.34909160549e-08 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | RNA modification |
| GO:0016607 | 7.24645069198e-06 | 0.7 | RBM15B METTL3 ZC3H13 VIRMA NME8 CBLL1 WTAP | nuclear speck |
| CORUM:929 | 9.96450861922e-05 | 0.3 | VIRMA WTAP ZC3H13 | CEN complex |
| GO:0016071 | 0.000588630117702 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | mRNA metabolic process |
| GO:0016604 | 0.00187652761406 | 0.7 | RBM15B METTL3 ZC3H13 VIRMA NME8 CBLL1 WTAP | nuclear body |
| GO:1990234 | 0.00609373273501 | 0.7 | RBM15B METTL14 METTL3 ZC3H13 VIRMA CBLL1 WTAP | transferase complex |
| GO:1902494 | 0.0260248958425 | 0.8 | RBM15B VIRMA METTL3 ZC3H13 METTL14 NME8 CBLL1 WTAP | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| METTL14 | METTL3 | 1.0 | 0.214 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () Malo fraction |
| WTAP | VIRMA | 1.0 | 0.606 | hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL2 | VIRMA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | CBLL2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | METTL3 | 0.999 | 0.196 | hein_WMM bioplex_WMM youn_WMM hein () |
| CBLL2 | ZC3H13 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VIRMA | ZC3H13 | 0.999 | 0.294 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| WTAP | ZC3H13 | 0.995 | 0.242 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL1 | VIRMA | 0.987 | 0.1 | youn () youn_WMM Malo fraction |
| WTAP | METTL14 | 0.986 | 0.238 | hein_WMM youn_WMM WMM_only |
| METTL3 | RBM15B | 0.981 | 0.088 | hein_WMM youn_WMM hein () |
| RBM15B | ZC3H13 | 0.981 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WTAP | RBM15B | 0.936 | 0.216 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| METTL3 | VIRMA | 0.907 | 0.168 | youn () youn_WMM WMM_only |
| WTAP | WAC | 0.9 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| WTAP | CBLL1 | 0.868 | 0.594 | youn_WMM Malo fraction |
| RBM15B | NME8 | 0.828 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| METTL14 | VIRMA | 0.595 | 0.194 | youn () youn_WMM WMM_only |
| WAC | VIRMA | 0.465 | hein_WMM youn () youn_WMM WMM_only | |
| CBLL1 | ZC3H13 | 0.423 | 0.286 | hein_WMM WMM_only |
| METTL3 | CBLL1 | 0.287 | 0.142 | youn_WMM WMM_only |
| METTL14 | CBLL1 | 0.271 | 0.21 | youn_WMM WMM_only |
| METTL14 | RBM15B | 0.192 | 0.128 | hein_WMM WMM_only |
| WAC | CBLL1 | 0.145 | youn_WMM WMM_only | |
| WAC | ZC3H13 | 0.136 | hein_WMM youn_WMM WMM_only | |
| VIRMA | RBM15B | 0.086 | 0.164 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| METTL14 | WAC | 0.084 | youn_WMM gupta_WMM WMM_only | |
| METTL3 | WAC | 0.023 | bioplex3_WMM youn_WMM WMM_only | |
| CBLL1 | RBM15B | 0.014 | 0.166 | youn_WMM WMM_only |
| WTAP | NME8 | 0.011 | boldt WMM_only boldt_WMM | |
| METTL3 | ZC3H13 | 0.011 | 0.186 | youn_WMM WMM_only |
| WAC | RBM15B | 0.006 | youn_WMM WMM_only |
Related Complexes