hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12737.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CARMIL1 | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | 5 | UniProt NCBI |
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | 5 | UniProt NCBI |
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | 5 | UniProt NCBI |
| PARM1 | Prostate androgen-regulated mucin-like protein 1 (PARM-1) | 5 | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 0.0011839189519 | 0.4 | PAK4 PAK5 | Activation of RAC1 |
| WP:WP4564 | 0.00328532749654 | 0.4 | PAK4 PAK5 | Neural crest cell migration during development |
| WP:WP4565 | 0.00368839425913 | 0.4 | PAK4 PAK5 | Neural crest cell migration in cancer |
| WP:WP4534 | 0.00456408083355 | 0.4 | PAK4 PAK5 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| REAC:R-HSA-9013407 | 0.00849065158197 | 0.4 | PAK4 PAK5 | RHOH GTPase cycle |
| WP:WP4205 | 0.00931707261303 | 0.4 | PAK4 PAK5 | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 0.00937366158534 | 0.4 | PAK4 PAK5 | Renal cell carcinoma |
| KEGG:04012 | 0.0128243509281 | 0.4 | PAK4 PAK5 | ErbB signaling pathway |
| WP:WP4263 | 0.0188521857166 | 0.4 | PAK4 PAK5 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | PAK4 PAK5 | ErbB signaling pathway |
| KEGG:04660 | 0.0235498516465 | 0.4 | PAK4 PAK5 | T cell receptor signaling pathway |
| WP:WP4541 | 0.0264781270697 | 0.4 | PAK4 PAK5 | Hippo Merlin signaling dysregulation |
| WP:WP51 | 0.046989062869 | 0.4 | PAK4 PAK5 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PAK4 | PAK5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CARMIL1 | PARM1 | 0.992 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CARMIL1 | PAK5 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GMPPA | PAK5 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PAK4 | CARMIL1 | 0.685 | 0.026 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GMPPA | CARMIL1 | 0.052 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only |
| PAK4 | GMPPA | 0.028 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes