hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12747.1

Complex Portal: CPX-12582

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RRM2	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	5	UniProt NCBI
MAGIX	PDZ domain-containing protein MAGIX	3	UniProt NCBI
ZNF207	BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)	5	UniProt NCBI
BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)	5	UniProt NCBI
ANAPC16	Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16)	5	UniProt NCBI
PENK	Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe]	5	UniProt NCBI
FZR1	Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)	5	UniProt NCBI
CDC20	Cell division cycle protein 20 homolog (p55CDC)	5	UniProt NCBI
ANAPC15	Anaphase-promoting complex subunit 15 (APC15)	5	UniProt NCBI
CDC23	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)	5	UniProt NCBI
SORBS3	Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)	5	UniProt NCBI
ANAPC13	Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)	4	UniProt NCBI
CDC16	Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)	5	UniProt NCBI
NEK2	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)	5	UniProt NCBI
ANAPC10	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10)	5	UniProt NCBI
CDC26	Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog)	5	UniProt NCBI
ANAPC7	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)	5	UniProt NCBI
BUB3	Mitotic checkpoint protein BUB3	5	UniProt NCBI
ANAPC4	Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)	5	UniProt NCBI
ANAPC1	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)	5	UniProt NCBI
CDC27	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	5	UniProt NCBI
ANAPC5	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	5	UniProt NCBI
CFAP97	Cilia- and flagella-associated protein 97	3	UniProt NCBI
ANAPC2	Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)	5	UniProt NCBI
FBXO5	F-box only protein 5 (Early mitotic inhibitor 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-179409	5.65206077898e-36	0.625	NEK2 CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	APC-Cdc20 mediated degradation of Nek2A
GO:0005680	1.57056804456e-35	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	anaphase-promoting complex
REAC:R-HSA-141430	9.80471469217e-35	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Inactivation of APC/C via direct inhibition of the APC/C complex
REAC:R-HSA-141405	9.80471469217e-35	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
REAC:R-HSA-176407	9.10742158434e-32	0.541666666667	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 CDC16	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
GO:0031145	1.34911744126e-31	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	anaphase-promoting complex-dependent catabolic process
REAC:R-HSA-453276	2.26628160103e-31	0.708333333333	NEK2 ANAPC16 CDC23 FZR1 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Regulation of mitotic cell cycle
REAC:R-HSA-174143	2.26628160103e-31	0.708333333333	NEK2 ANAPC16 CDC23 FZR1 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	APC/C-mediated degradation of cell cycle proteins
GO:0051445	7.20114669777e-30	0.625	CDC23 ANAPC16 ANAPC10 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	regulation of meiotic cell cycle
REAC:R-HSA-176408	2.23801772888e-29	0.666666666667	ANAPC16 CDC23 FZR1 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Regulation of APC/C activators between G1/S and early anaphase
GO:0000152	6.56637172425e-29	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	nuclear ubiquitin ligase complex
REAC:R-HSA-9687136	2.05597574904e-28	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Aberrant regulation of mitotic exit in cancer due to RB1 defects
KEGG:04110	1.37002303637e-27	0.708333333333	ANAPC16 CDC23 FZR1 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	Cell cycle
REAC:R-HSA-179419	1.94425197002e-27	0.625	NEK2 CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REAC:R-HSA-176409	3.06565449746e-27	0.625	NEK2 CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	APC/C:Cdc20 mediated degradation of mitotic proteins
REAC:R-HSA-176814	3.82984537271e-27	0.625	NEK2 CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REAC:R-HSA-174048	5.50013990157e-27	0.5	CDC23 CDC20 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	APC/C:Cdc20 mediated degradation of Cyclin B
REAC:R-HSA-176412	3.46025613656e-25	0.458333333333	CDC16 ANAPC1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 CDC23	Phosphorylation of the APC/C
REAC:R-HSA-174184	5.89349447062e-25	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REAC:R-HSA-9687139	3.36368054166e-24	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Aberrant regulation of mitotic cell cycle due to RB1 defects
REAC:R-HSA-9675126	7.45603080564e-24	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Diseases of mitotic cell cycle
REAC:R-HSA-8853884	7.45603080564e-24	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Transcriptional Regulation by VENTX
GO:0007346	9.46026400084e-24	0.833333333333	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 FZR1 ZNF207 ANAPC13 CDC16	regulation of mitotic cell cycle
GO:2000241	2.57874432973e-23	0.625	CDC23 ANAPC16 ANAPC10 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	regulation of reproductive process
KEGG:04114	3.88159590647e-23	0.583333333333	CDC20 CDC23 ANAPC13 ANAPC10 FBXO5 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Oocyte meiosis
REAC:R-HSA-174178	2.29333596338e-22	0.541666666667	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 CDC16	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
KEGG:04914	2.91787660344e-22	0.541666666667	CDC23 ANAPC13 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 CDC16	Progesterone-mediated oocyte maturation
REAC:R-HSA-69618	3.34082174615e-22	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Mitotic Spindle Checkpoint
CORUM:96	4.32527534848e-22	0.333333333333	ANAPC4 ANAPC10 ANAPC7 ANAPC1 ANAPC5 CDC16 ANAPC2 CDC23	Anaphase-promoting complex
KEGG:04120	1.82446350061e-21	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	Ubiquitin mediated proteolysis
KEGG:05166	3.98442717721e-21	0.625	ANAPC16 CDC23 ANAPC13 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Human T-cell leukemia virus 1 infection
REAC:R-HSA-174084	1.05298201792e-20	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Autodegradation of Cdh1 by Cdh1:APC/C
GO:0070979	1.6297838753e-20	0.458333333333	CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	protein K11-linked ubiquitination
REAC:R-HSA-174154	1.93817746992e-20	0.5	CDC23 CDC20 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	APC/C:Cdc20 mediated degradation of Securin
REAC:R-HSA-69017	5.02138963576e-20	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	CDK-mediated phosphorylation and removal of Cdc6
GO:0051321	8.05473537389e-20	0.625	CDC23 ANAPC16 ANAPC10 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	meiotic cell cycle
REAC:R-HSA-2555396	1.30805725749e-19	0.625	CDC23 ANAPC16 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Mitotic Metaphase and Anaphase
REAC:R-HSA-69278	2.54738803801e-19	0.75	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 FZR1 ANAPC1 CDC16	Cell Cycle, Mitotic
GO:0031461	2.8061515382e-19	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	cullin-RING ubiquitin ligase complex
CORUM:93	3.71668366415e-19	0.291666666667	ANAPC4 ANAPC2 ANAPC7 ANAPC1 CDC16 ANAPC5 CDC23	Anaphase-promoting complex
REAC:R-HSA-2467813	8.01792584563e-19	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Separation of Sister Chromatids
REAC:R-HSA-69052	1.05882092285e-18	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Switching of origins to a post-replicative state
GO:0000278	2.63655701739e-18	0.833333333333	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 FZR1 ZNF207 ANAPC13 CDC16	mitotic cell cycle
REAC:R-HSA-2559582	2.74106220997e-18	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Senescence-Associated Secretory Phenotype (SASP)
REAC:R-HSA-68886	7.80509426586e-18	0.666666666667	NEK2 CDC23 ANAPC16 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	M Phase
REAC:R-HSA-1640170	1.06537040429e-17	0.75	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 FZR1 ANAPC1 CDC16	Cell Cycle
WP:WP179	1.11618660953e-17	0.5	CDC20 CDC16 ANAPC13 ANAPC10 ANAPC7 BUB3 FZR1 ANAPC5 ANAPC2 ANAPC4 ANAPC1 CDC23	Cell cycle
REAC:R-HSA-68882	1.26256203271e-17	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Mitotic Anaphase
GO:0051726	3.12968281228e-17	0.833333333333	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 FZR1 ZNF207 ANAPC13 CDC16	regulation of cell cycle
REAC:R-HSA-69239	3.58778164842e-17	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Synthesis of DNA
GO:0007091	9.9012231111e-17	0.5	CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	metaphase/anaphase transition of mitotic cell cycle
REAC:R-HSA-68867	1.08060358809e-16	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Assembly of the pre-replicative complex
GO:0044784	1.32786491477e-16	0.5	CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	metaphase/anaphase transition of cell cycle
REAC:R-HSA-69620	3.05198221046e-16	0.583333333333	CDC23 ANAPC16 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 CDC16	Cell Cycle Checkpoints
GO:0033045	3.51522380965e-16	0.5	CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	regulation of sister chromatid segregation
REAC:R-HSA-69002	4.96043850284e-16	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	DNA Replication Pre-Initiation
GO:0000151	5.93870400278e-16	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	ubiquitin ligase complex
REAC:R-HSA-69242	1.30613740742e-15	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	S Phase
REAC:R-HSA-69306	3.95478522184e-15	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	DNA Replication
REAC:R-HSA-2559583	4.24268327579e-15	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Cellular Senescence
GO:0051983	5.99159535285e-15	0.5	CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	regulation of chromosome segregation
GO:0010965	1.22434402196e-14	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of mitotic sister chromatid separation
GO:0019953	1.37073274731e-14	0.666666666667	CDC23 ANAPC16 ANAPC10 CFAP97 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	sexual reproduction
GO:0051306	1.84881274329e-14	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	mitotic sister chromatid separation
GO:0007088	5.60985469094e-14	0.458333333333	NEK2 CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of mitotic nuclear division
GO:0051783	1.27259453621e-13	0.458333333333	NEK2 CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of nuclear division
GO:0007049	1.59482050245e-13	0.833333333333	NEK2 ANAPC16 CDC23 RRM2 BUB3 BUB1B FBXO5 CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 FZR1 ZNF207 ANAPC13 CDC16	cell cycle
GO:1905818	1.61296042447e-13	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of chromosome separation
GO:0033044	2.93141766769e-13	0.541666666667	NEK2 CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	regulation of chromosome organization
GO:0051304	4.07791934199e-13	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	chromosome separation
GO:0098813	5.41057799443e-13	0.541666666667	NEK2 CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	nuclear chromosome segregation
GO:0043161	6.18678777796e-13	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044772	7.62899949361e-13	0.583333333333	CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC1 FZR1 ZNF207 CDC16	mitotic cell cycle phase transition
GO:0022414	1.37655496669e-12	0.666666666667	CDC23 ANAPC16 ANAPC10 CFAP97 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	reproductive process
REAC:R-HSA-983168	1.38964330393e-12	0.5	CDC20 CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	Antigen processing: Ubiquitination & Proteasome degradation
GO:0000003	1.53030298173e-12	0.666666666667	CDC23 ANAPC16 ANAPC10 CFAP97 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	reproduction
GO:0030071	1.61275942211e-12	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of mitotic metaphase/anaphase transition
GO:1902099	2.07783990574e-12	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	regulation of metaphase/anaphase transition of cell cycle
GO:0000819	3.62486023633e-12	0.5	CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	sister chromatid segregation
REAC:R-HSA-983169	1.60928273391e-11	0.5	CDC20 CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	Class I MHC mediated antigen processing & presentation
GO:0044770	1.65054400679e-11	0.583333333333	CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC1 FZR1 ZNF207 CDC16	cell cycle phase transition
GO:0010498	1.76330253529e-11	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	proteasomal protein catabolic process
GO:0010564	1.8486904022e-11	0.625	NEK2 CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC1 FZR1 ZNF207 CDC16	regulation of cell cycle process
GO:0007059	2.36838796495e-11	0.541666666667	NEK2 CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	chromosome segregation
GO:1903047	5.90353341413e-11	0.625	NEK2 CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC1 FZR1 ZNF207 CDC16	mitotic cell cycle process
GO:1901990	9.57093337752e-11	0.5	CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 FZR1 ZNF207 CDC16	regulation of mitotic cell cycle phase transition
GO:0006511	1.40118088821e-10	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	ubiquitin-dependent protein catabolic process
GO:0019941	1.75301795597e-10	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	modification-dependent protein catabolic process
GO:0043632	2.37110785476e-10	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	modification-dependent macromolecule catabolic process
GO:0016567	2.86351348881e-10	0.583333333333	CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	protein ubiquitination
GO:0000209	6.32099101228e-10	0.458333333333	CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	protein polyubiquitination
GO:0140014	9.91330582848e-10	0.458333333333	NEK2 CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	mitotic nuclear division
GO:0032446	1.69164746807e-09	0.583333333333	CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	protein modification by small protein conjugation
GO:0000070	1.7055097088e-09	0.416666666667	CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	mitotic sister chromatid segregation
GO:1901987	2.25905201923e-09	0.5	CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 FZR1 ZNF207 CDC16	regulation of cell cycle phase transition
GO:0051603	2.44762578105e-09	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	proteolysis involved in protein catabolic process
GO:1990234	2.80437567761e-09	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	transferase complex
GO:0140535	6.5117738236e-09	0.625	ANAPC16 CDC23 FZR1 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	intracellular protein-containing complex
GO:0070647	6.56559246977e-09	0.583333333333	CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	protein modification by small protein conjugation or removal
GO:0051276	7.02164863494e-09	0.541666666667	NEK2 CDC23 ANAPC1 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	chromosome organization
GO:0043687	1.61176669957e-08	0.583333333333	CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	post-translational protein modification
GO:0140513	2.14832128353e-08	0.666666666667	ANAPC16 CDC23 FZR1 BUB3 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 ANAPC1 ANAPC13 CDC16	nuclear protein-containing complex
REAC:R-HSA-1280218	3.43686878368e-08	0.5	CDC20 CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	Adaptive Immune System
GO:0000280	3.81148557403e-08	0.458333333333	NEK2 CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	nuclear division
GO:0030163	6.20616338679e-08	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	protein catabolic process
GO:0022402	8.28624735536e-08	0.625	NEK2 CDC23 RRM2 BUB3 BUB1B FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC1 FZR1 ZNF207 CDC16	cell cycle process
REAC:R-HSA-2262752	9.18572594885e-08	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Cellular responses to stress
REAC:R-HSA-8953897	1.02637147954e-07	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Cellular responses to stimuli
GO:0048285	1.35881581121e-07	0.458333333333	NEK2 CDC23 FBXO5 BUB3 BUB1B ANAPC15 ANAPC7 CDC20 ANAPC5 ZNF207 CDC16	organelle fission
REAC:R-HSA-212436	3.32961612639e-07	0.541666666667	ANAPC16 CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 RRM2 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Generic Transcription Pathway
GO:1901992	4.49697810651e-07	0.291666666667	CDC16 CDC20 FBXO5 ANAPC7 RRM2 ANAPC5 CDC23	positive regulation of mitotic cell cycle phase transition
CORUM:190	4.71120641517e-07	0.125	BUB1B BUB3 CDC20	Mitotic checkpoint complex (MCC)
GO:0033043	5.44867259789e-07	0.583333333333	NEK2 ANAPC7 CDC23 ANAPC1 BUB3 BUB1B FBXO5 SORBS3 ANAPC15 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	regulation of organelle organization
GO:1902101	7.58768892253e-07	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of metaphase/anaphase transition of cell cycle
GO:0045842	7.58768892253e-07	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of mitotic metaphase/anaphase transition
REAC:R-HSA-73857	1.28038542172e-06	0.541666666667	ANAPC16 CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 RRM2 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	RNA Polymerase II Transcription
GO:1901989	2.35616262626e-06	0.291666666667	CDC16 CDC20 FBXO5 ANAPC7 RRM2 ANAPC5 CDC23	positive regulation of cell cycle phase transition
GO:0045841	2.51342958843e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of mitotic metaphase/anaphase transition
GO:0033048	2.51342958843e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of mitotic sister chromatid segregation
GO:0033046	2.51342958843e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of sister chromatid segregation
GO:2000816	2.51342958843e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of mitotic sister chromatid separation
GO:1902494	3.0772290451e-06	0.666666666667	ANAPC16 CDC23 RRM2 BUB1B CDC26 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 ANAPC10 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	catalytic complex
GO:1901970	3.23326051362e-06	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of mitotic sister chromatid separation
GO:1902100	3.37507529641e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of metaphase/anaphase transition of cell cycle
GO:0051985	3.37507529641e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of chromosome segregation
GO:1905819	3.37507529641e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of chromosome separation
GO:0045931	4.20967788482e-06	0.291666666667	CDC16 CDC20 FBXO5 ANAPC7 RRM2 ANAPC5 CDC23	positive regulation of mitotic cell cycle
GO:0009057	4.39672828416e-06	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	macromolecule catabolic process
GO:0006508	4.74508920657e-06	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	proteolysis
GO:1901565	4.86673970354e-06	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	organonitrogen compound catabolic process
GO:0033047	5.84247438024e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	regulation of mitotic sister chromatid segregation
REAC:R-HSA-74160	5.88055435997e-06	0.541666666667	ANAPC16 CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 RRM2 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Gene expression (Transcription)
GO:0045839	6.6506610037e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of mitotic nuclear division
GO:0051784	9.65175571636e-06	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of nuclear division
REAC:R-HSA-176417	2.32237791919e-05	0.125	FZR1 FBXO5 CDC20	Phosphorylation of Emi1
GO:1905820	3.66872341026e-05	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of chromosome separation
GO:0045840	7.48466908255e-05	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of mitotic nuclear division
CORUM:5361	7.83172113594e-05	0.0833333333333	CDC16 ANAPC7	Cell division cycle complex (CDC27, CDC16, ANAPC7)
GO:1901991	0.000117121371563	0.291666666667	FZR1 BUB1B FBXO5 BUB3 ANAPC15 CDC20 ZNF207	negative regulation of mitotic cell cycle phase transition
GO:0010948	0.000124932851974	0.333333333333	NEK2 FZR1 BUB1B FBXO5 ANAPC15 BUB3 CDC20 ZNF207	negative regulation of cell cycle process
GO:0051785	0.000161135904519	0.208333333333	CDC20 ANAPC7 ANAPC5 CDC23 CDC16	positive regulation of nuclear division
WP:WP4240	0.000179436010478	0.125	BUB1B BUB3 CDC20	Regulation of sister chromatid separation at the metaphase anaphase transition
GO:2001251	0.00023069370815	0.25	CDC20 BUB1B BUB3 ANAPC15 FBXO5 ZNF207	negative regulation of chromosome organization
GO:0071174	0.000275826238424	0.208333333333	BUB3 BUB1B ANAPC15 ZNF207 CDC20	mitotic spindle checkpoint signaling
GO:0071173	0.000275826238424	0.208333333333	BUB3 BUB1B ANAPC15 ZNF207 CDC20	spindle assembly checkpoint signaling
GO:0007094	0.000275826238424	0.208333333333	BUB3 BUB1B ANAPC15 ZNF207 CDC20	mitotic spindle assembly checkpoint signaling
REAC:R-HSA-1643685	0.000292665298982	0.5	CDC23 FZR1 ANAPC10 ANAPC15 ANAPC7 ANAPC16 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC16	Disease
GO:0031577	0.00031276040178	0.208333333333	BUB3 BUB1B ANAPC15 ZNF207 CDC20	spindle checkpoint signaling
GO:1901575	0.000502114635225	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	organic substance catabolic process
GO:0045930	0.000598769414122	0.291666666667	FZR1 BUB1B FBXO5 BUB3 ANAPC15 CDC20 ZNF207	negative regulation of mitotic cell cycle
GO:0090068	0.000696098115039	0.291666666667	CDC16 CDC20 FBXO5 ANAPC7 RRM2 ANAPC5 CDC23	positive regulation of cell cycle process
GO:0033597	0.000777349058504	0.125	BUB1B BUB3 CDC20	mitotic checkpoint complex
GO:0045786	0.00083588374239	0.333333333333	NEK2 FZR1 BUB1B FBXO5 ANAPC15 BUB3 CDC20 ZNF207	negative regulation of cell cycle
REAC:R-HSA-168256	0.00114833082322	0.5	CDC20 CDC16 ANAPC13 ANAPC10 ANAPC7 FZR1 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 CDC23	Immune System
GO:1901988	0.00127399530266	0.291666666667	FZR1 BUB1B FBXO5 BUB3 ANAPC15 CDC20 ZNF207	negative regulation of cell cycle phase transition
GO:0007093	0.00196148698286	0.25	FZR1 BUB1B BUB3 ANAPC15 CDC20 ZNF207	mitotic cell cycle checkpoint signaling
GO:0051128	0.00246967845602	0.583333333333	NEK2 ANAPC7 CDC23 ANAPC1 BUB3 BUB1B FBXO5 SORBS3 ANAPC15 CDC20 ANAPC5 ANAPC2 ZNF207 CDC16	regulation of cellular component organization
GO:0036211	0.00314665413693	0.625	NEK2 CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	protein modification process
GO:0000776	0.0035605353074	0.25	NEK2 ANAPC16 BUB1B BUB3 CDC20 ZNF207	kinetochore
GO:0000779	0.00422714789849	0.25	NEK2 ANAPC16 BUB1B BUB3 CDC20 ZNF207	condensed chromosome, centromeric region
GO:0045787	0.00438141710618	0.291666666667	CDC16 CDC20 FBXO5 ANAPC7 RRM2 ANAPC5 CDC23	positive regulation of cell cycle
GO:0009056	0.00857974928733	0.583333333333	CDC23 ANAPC16 ANAPC10 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC16	catabolic process
GO:0043412	0.00964136328964	0.625	NEK2 CDC16 ANAPC16 ANAPC10 FBXO5 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 FZR1 ANAPC1 ANAPC13 CDC23	macromolecule modification
GO:0000075	0.0103710746879	0.25	FZR1 BUB1B BUB3 ANAPC15 CDC20 ZNF207	cell cycle checkpoint signaling
HPA:0310431	0.0125150093512	0.708333333333	NEK2 ANAPC16 CDC23 RRM2 BUB3 ANAPC10 FBXO5 ANAPC15 ANAPC7 CDC20 ANAPC5 ANAPC2 CDC26 ANAPC4 ANAPC1 ZNF207 CDC16	lymph node; germinal center cells[>=Low]
GO:0010997	0.0162365457737	0.125	FZR1 FBXO5 CDC20	anaphase-promoting complex binding
REAC:R-HSA-174113	0.0273497524969	0.125	FZR1 FBXO5 CDC20	SCF-beta-TrCP mediated degradation of Emi1
GO:0000775	0.0296577521147	0.25	NEK2 ANAPC16 BUB1B BUB3 CDC20 ZNF207	chromosome, centromeric region
GO:0000793	0.0374984050328	0.25	NEK2 ANAPC16 BUB1B BUB3 CDC20 ZNF207	condensed chromosome
CORUM:1932	0.0497620750785	0.0416666666667	NEK2	NEK2-NEK11 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ANAPC4	ANAPC5	1.0	0.468	structurally_consistent (dimer)
ANAPC1	ANAPC5	1.0	0.79	structurally_consistent (dimer)
CDC16	ANAPC1	1.0	0.498
CDC16	ANAPC4	1.0	0.276
ANAPC16	ANAPC4	1.0	0.15
CDC23	CDC16	1.0	0.752
ANAPC5	ANAPC2	1.0	0.436
ANAPC16	ANAPC1	1.0	0.194
CDC16	ANAPC5	1.0	0.408
ANAPC4	ANAPC2	1.0	0.418	structurally_consistent (dimer)
ANAPC16	CDC23	1.0	0.244
ANAPC16	ANAPC7	1.0	0.534
CDC16	ANAPC2	1.0	0.348
CDC26	ANAPC1	1.0	0.218
ANAPC16	CDC27	1.0	0.296	structurally_consistent (dimer)
ANAPC16	ANAPC2	1.0	0.29
CDC26	ANAPC4	1.0	0.062
CDC26	ANAPC2	1.0	0.194
ANAPC16	ANAPC5	1.0	0.336
CDC16	CDC27	1.0	0.124	structurally_consistent (dimer)
CDC16	ANAPC10	1.0	0.21	structurally_consistent (P30260) structurally_consistent (dimer)
CDC23	ANAPC4	1.0	0.586	structurally_consistent (Q9UJX4)
ANAPC10	ANAPC4	1.0	0.232
CDC23	CDC27	1.0	0.188
CDC26	ANAPC7	1.0	0.106
ANAPC13	ANAPC2	1.0	0.088
CDC23	ANAPC5	1.0	0.628	structurally_consistent (dimer)
CDC26	ANAPC5	1.0	0.15
ANAPC7	ANAPC5	1.0	0.436
ANAPC16	CDC16	1.0	0.18	structurally_consistent (P30260)
ANAPC4	CDC27	1.0	0.186	structurally_consistent (Q9UJX6)
FZR1	CDC16	1.0	0.132
ANAPC4	ANAPC1	1.0	0.402	structurally_consistent (Q9UJX6)
ANAPC1	CDC27	1.0	0.354	structurally_consistent (Q9UJX6)
ANAPC13	CDC26	1.0	0.132
ANAPC13	CDC16	1.0	0.086
CDC23	ANAPC10	1.0	0.262	structurally_consistent (dimer)
ANAPC10	ANAPC2	1.0	0.236	structurally_consistent (Q9H1A4)
ANAPC16	CDC26	1.0	0.198
ANAPC13	CDC27	1.0	0.122
ANAPC13	ANAPC4	1.0	0.19
CDC23	ANAPC2	1.0	0.226
ANAPC16	ANAPC13	1.0	0.168
CDC27	ANAPC2	1.0	0.088	structurally_consistent (dimer)
ANAPC7	ANAPC2	1.0	0.19
ANAPC1	ANAPC2	1.0	0.448	structurally_consistent (dimer)
CDC26	CDC27	1.0	0.166	structurally_consistent (Q9UM11)
ANAPC10	ANAPC5	1.0	0.208	structurally_consistent (Q9H1A4)
CDC16	CDC26	1.0	0.186
ANAPC16	ANAPC10	1.0	0.354
FZR1	CDC26	1.0	0.1	structurally_consistent (dimer)
ANAPC10	CDC26	1.0	0.208	mutually_exclusive (O43684)
ANAPC13	ANAPC10	1.0	0.176
ANAPC7	ANAPC4	1.0	0.3
FZR1	CDC23	1.0	0.138
CDC23	CDC26	1.0	0.112
CDC27	ANAPC5	1.0	0.486
ANAPC13	ANAPC1	1.0	0.17
ANAPC13	ANAPC7	1.0	0.136
ANAPC10	CDC27	1.0	0.172	structurally_consistent (Q9UM11) structurally_consistent (dimer)
ANAPC7	ANAPC1	1.0	0.416
ANAPC13	ANAPC5	1.0	0.132
CDC23	ANAPC13	1.0	0.166
CDC26	FBXO5	1.0	0.156
FZR1	CDC27	1.0	0.08	structurally_consistent (dimer)
FZR1	ANAPC2	1.0	0.07
ANAPC2	FBXO5	0.999	0.052
FZR1	ANAPC16	0.999	0.128	structurally_consistent (dimer)
ANAPC7	FBXO5	0.999	0.212
ANAPC10	FBXO5	0.999	0.15
CDC23	ANAPC1	0.999	0.528	structurally_consistent (Q9UM13)
ANAPC10	ANAPC7	0.999	0.274
FZR1	ANAPC5	0.999	0.08
BUB1B	BUB3	0.999	0.42	structurally_consistent (dimer)
CDC16	FBXO5	0.999	0.132
ANAPC16	FBXO5	0.999	0.082
CDC23	FBXO5	0.999	0.174
FZR1	ANAPC4	0.999	0.134
CDC27	FBXO5	0.999	0.174
CDC23	ANAPC7	0.999	0.548
ANAPC7	CDC27	0.999	0.622
CDC16	ANAPC7	0.999	0.188
FZR1	ANAPC1	0.999	0.19
ANAPC10	ANAPC1	0.999	0.282	structurally_consistent (dimer)
NEK2	ANAPC2	0.999	0.16
FZR1	ANAPC7	0.999	0.124
ANAPC5	FBXO5	0.999	0.114
FZR1	FBXO5	0.999	0.12
ANAPC1	FBXO5	0.999	0.121333333333
FZR1	ANAPC10	0.999	0.16	mutually_exclusive (O43684) structurally_consistent (dimer)
CDC20	CDC26	0.999	0.228206185567
FZR1	RRM2	0.998	0.092	structurally_consistent (dimer)
BUB1B	ANAPC2	0.998	0.116
CDC20	ANAPC5	0.998	0.098
FZR1	ANAPC13	0.998	0.076
CDC20	FBXO5	0.998	0.15637037037
ANAPC4	FBXO5	0.998	0.168
BUB1B	CDC20	0.998	0.212	structurally_consistent (dimer)
RRM2	ANAPC2	0.997	0.042
CDC20	ANAPC2	0.997	0.108
CDC20	CDC16	0.997	0.068	structurally_consistent (Q9UM13)
ANAPC16	NEK2	0.997	0.222
CDC20	ANAPC13	0.996	0.162
ANAPC13	FBXO5	0.996	0.102
RRM2	CDC26	0.996	0.088
ANAPC16	CDC20	0.995	0.246
ZNF207	BUB3	0.994	0.925333333333	structurally_consistent (dimer)
CDC20	BUB3	0.994	0.14	structurally_consistent (Q9UM13)
RRM2	FBXO5	0.994	0.178
BUB1B	CDC26	0.994	0.158	mutually_exclusive (O43684)
ANAPC16	CFAP97	0.994	0.122
CDC20	CDC23	0.994	0.0904666666667	structurally_consistent (Q9UM13) structurally_consistent (dimer)
CFAP97	ANAPC2	0.993	0.148
NEK2	ANAPC5	0.993	0.128
ANAPC15	ANAPC5	0.993	0.378
ANAPC15	ANAPC2	0.993	0.29
CDC26	CFAP97	0.992	0.11
CDC20	ANAPC1	0.992	0.206339622642	structurally_consistent (Q9UM13)
NEK2	CDC26	0.992	0.17
NEK2	ANAPC7	0.991	0.174
RRM2	CDC27	0.991	0.182
CDC27	CFAP97	0.991	0.054
ANAPC1	CFAP97	0.99	0.14
CDC23	CFAP97	0.988	0.062
ANAPC16	ANAPC15	0.988	0.144222222222
BUB1B	CDC23	0.988	0.114219858156	structurally_consistent (Q12834)
ANAPC15	CDC23	0.988	0.248
ANAPC15	CDC16	0.988	0.398
RRM2	CDC16	0.987	0.062
ANAPC15	CDC27	0.987	0.232
ANAPC15	ANAPC4	0.987	0.574
ANAPC15	ANAPC7	0.986	0.252115384615
FZR1	NEK2	0.986	0.192
ANAPC13	CFAP97	0.985	0.068
FZR1	CDC20	0.985	0.138560283688
CDC16	CFAP97	0.985	0.064
RRM2	CDC23	0.984	0.026
RRM2	ANAPC16	0.984	0.108	mutually_exclusive (Q9UM11)
ANAPC15	ANAPC1	0.982	0.464
MAGIX	ANAPC1	0.982
CFAP97	FBXO5	0.982	0.182
ANAPC13	NEK2	0.981	0.178
FZR1	CFAP97	0.981	0.114
MAGIX	CDC26	0.98
NEK2	ANAPC10	0.98	0.182
ANAPC15	CDC26	0.979	0.172	mutually_exclusive (O43684)
NEK2	ANAPC1	0.979	0.19
RRM2	ANAPC13	0.979	0.056
NEK2	CFAP97	0.979	0.18
CDC20	CDC27	0.978	0.166	structurally_consistent (Q9UM13)
FZR1	ANAPC15	0.978	0.2	mutually_exclusive (O43684)
MAGIX	CDC16	0.978
CDC20	ANAPC4	0.978	0.052
MAGIX	CDC27	0.978
ANAPC4	CFAP97	0.978	0.08
CDC20	ANAPC15	0.977	0.148
ANAPC10	CFAP97	0.977	0.078
NEK2	CDC27	0.977	0.084
CDC20	ANAPC10	0.976	0.254	structurally_consistent (dimer)
ANAPC2	BUB3	0.976	0.188285714286
ANAPC5	CFAP97	0.975	0.11
MAGIX	CDC23	0.974
CDC16	NEK2	0.974	0.202
BUB1B	ANAPC16	0.974	0.298
FZR1	BUB1B	0.971	0.146	mutually_exclusive (O43684)
CDC20	NEK2	0.97	0.2128875
NEK2	ANAPC4	0.967	0.07
NEK2	FBXO5	0.966	0.178
ANAPC15	FBXO5	0.966	0.154
CDC23	NEK2	0.964	0.116
ANAPC15	ANAPC13	0.962	0.2
RRM2	ANAPC10	0.962	0.148
BUB1B	ANAPC10	0.961	0.178	mutually_exclusive (O43684)
MAGIX	ANAPC16	0.961
ANAPC7	CFAP97	0.96	0.074
BUB1B	CDC16	0.957	0.1
ANAPC15	ANAPC10	0.956	0.274	mutually_exclusive (O43684)
CDC20	ANAPC7	0.953	0.052
BUB1B	FBXO5	0.952	0.198
ANAPC15	CFAP97	0.944	0.152
ANAPC16	BUB3	0.943	0.3
RRM2	BUB1B	0.937	0.406
SORBS3	ANAPC15	0.934	0.068
RRM2	ANAPC7	0.933	0.044
SORBS3	CDC26	0.933	0.078
CDC26	PENK	0.933
RRM2	ANAPC15	0.931	0.138
ANAPC15	NEK2	0.93	0.118
RRM2	ANAPC4	0.93	0.102
SORBS3	CDC23	0.928	0.052
FZR1	BUB3	0.925	0.14	structurally_consistent (dimer)
CDC23	BUB3	0.922	0.366
BUB1B	ANAPC5	0.92	0.070219858156
ANAPC13	BUB3	0.913	0.108
BUB1B	CDC27	0.912	0.118
MAGIX	ANAPC5	0.909
BUB1B	ANAPC15	0.905	0.192	mutually_exclusive (O43684)
CDC20	CFAP97	0.904	0.158560283688
BUB1B	ANAPC13	0.903	0.168320754717
RRM2	ANAPC5	0.899	0.094
ANAPC1	PENK	0.896
RRM2	CDC20	0.894	0.324
ANAPC16	PENK	0.888
MAGIX	ANAPC7	0.884
SORBS3	CDC20	0.877	0.07
BUB1B	ZNF207	0.868	0.112	mutually_exclusive (O43684)
CDC26	BUB3	0.868	0.48	structurally_consistent (dimer)
BUB1B	ANAPC1	0.842	0.224
SORBS3	CDC16	0.825	0.03
ANAPC5	BUB3	0.824	0.322
CDC16	BUB3	0.819	0.398
SORBS3	BUB3	0.814	0.13
BUB1B	NEK2	0.811	0.176
SORBS3	CFAP97	0.796	0.062
SORBS3	RRM2	0.796	0.05
SORBS3	ANAPC10	0.796	0.062
BUB1B	ANAPC7	0.782	0.072
SORBS3	FZR1	0.781	0.086
SORBS3	ANAPC7	0.781	0.014
SORBS3	ANAPC13	0.781	0.12
SORBS3	FBXO5	0.781	0.048
SORBS3	ANAPC4	0.781	0.024
SORBS3	NEK2	0.781	0.078
SORBS3	ANAPC2	0.781	0.03
MAGIX	ANAPC4	0.778
MAGIX	ANAPC2	0.776
BUB1B	CFAP97	0.772	0.086
BUB1B	ANAPC4	0.746	0.086
ANAPC1	BUB3	0.735	0.27
ANAPC4	PENK	0.723
CDC27	BUB3	0.722	0.252
SORBS3	ANAPC1	0.722	0.048
RRM2	ANAPC1	0.714	0.08
SORBS3	CDC27	0.712	0.06
ANAPC10	BUB3	0.688	0.404	structurally_consistent (dimer)
ANAPC7	BUB3	0.665	0.242
RRM2	NEK2	0.648	0.116
SORBS3	ANAPC16	0.641	0.036
SORBS3	ANAPC5	0.641	0.088
CDC23	PENK	0.631
RRM2	CFAP97	0.528	0.078
ANAPC15	BUB3	0.445	0.412	structurally_consistent (dimer)
FBXO5	BUB3	0.421	0.244
ANAPC4	BUB3	0.374	0.21
CDC27	PENK	0.306
CFAP97	BUB3	0.269	0.08
ANAPC5	PENK	0.219
CDC20	ZNF207	0.152	0.33112195122
SORBS3	BUB1B	0.118	0.048
ANAPC16	ZNF207	0.096	0.14
NEK2	BUB3	0.057	0.102
CDC23	ZNF207	0.026	0.222
CDC27	ZNF207	0.022	0.168
ANAPC5	ZNF207	0.015	0.192
ANAPC4	ZNF207	0.01	0.1
RRM2	BUB3	0.009	0.148	mutually_exclusive (Q9UM11)
CDC16	ZNF207	0.009	0.13
ANAPC1	ZNF207	0.008	0.202
RRM2	ZNF207	0.005	0.084
ANAPC7	ZNF207	0.004	0.118
BUB3	PENK	0.002
MAGIX	BUB3	0.002

Related Complexes

Genename	Complexes
RRM2	huMAP3_03279.1 huMAP3_03388.1 huMAP3_07989.1 huMAP3_11033.1 huMAP3_12747.1
MAGIX	huMAP3_00239.1 huMAP3_12747.1 huMAP3_14522.1 huMAP3_15110.1
ZNF207	huMAP3_03960.1 huMAP3_12747.1
BUB1B	huMAP3_03388.1 huMAP3_12747.1
ANAPC16	huMAP3_03388.1 huMAP3_12747.1
PENK	huMAP3_04796.1 huMAP3_04898.1 huMAP3_12747.1
FZR1	huMAP3_00732.1 huMAP3_03388.1 huMAP3_07079.1 huMAP3_09021.1 huMAP3_12747.1 huMAP3_13744.1
CDC20	huMAP3_03388.1 huMAP3_12747.1
ANAPC15	huMAP3_03388.1 huMAP3_12747.1
CDC23	huMAP3_03388.1 huMAP3_12747.1
SORBS3	huMAP3_00344.1 huMAP3_05643.1 huMAP3_07114.1 huMAP3_09976.1 huMAP3_10539.1 huMAP3_12747.1 huMAP3_14607.1
ANAPC13	huMAP3_03388.1 huMAP3_12747.1
CDC16	huMAP3_03388.1 huMAP3_12097.1 huMAP3_12747.1
NEK2	huMAP3_03388.1 huMAP3_12747.1
ANAPC10	huMAP3_03388.1 huMAP3_12747.1
CDC26	huMAP3_03388.1 huMAP3_12747.1
ANAPC7	huMAP3_03388.1 huMAP3_12747.1
BUB3	huMAP3_03960.1 huMAP3_12747.1
ANAPC4	huMAP3_03388.1 huMAP3_12747.1
ANAPC1	huMAP3_03388.1 huMAP3_12747.1
CDC27	huMAP3_03388.1 huMAP3_12747.1
ANAPC5	huMAP3_03388.1 huMAP3_12747.1
CFAP97	huMAP3_03388.1 huMAP3_12747.1 huMAP3_15205.1
ANAPC2	huMAP3_03388.1 huMAP3_12747.1
FBXO5	huMAP3_03388.1 huMAP3_12747.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12747.1

Complex Portal: CPX-12582