hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12759.1
Complex Portal: CPX-25091
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT1A | Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA) | 5 | UniProt NCBI |
| MT1F | Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF) | 5 | UniProt NCBI |
| MT1E | Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE) | 5 | UniProt NCBI |
| MT2A | Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5661231 | 1.4404725005e-12 | 1.0 | MT1A MT2A MT1E MT1F | Metallothioneins bind metals |
| REAC:R-HSA-5660526 | 3.36110250117e-12 | 1.0 | MT1A MT2A MT1E MT1F | Response to metal ions |
| WP:WP3529 | 4.19806067464e-10 | 1.0 | MT1A MT2A MT1E MT1F | Zinc homeostasis |
| GO:1990169 | 1.84188417064e-09 | 1.0 | MT1A MT2A MT1E MT1F | stress response to copper ion |
| GO:0010273 | 1.84188417064e-09 | 1.0 | MT1A MT2A MT1E MT1F | detoxification of copper ion |
| WP:WP3286 | 3.24724179284e-09 | 1.0 | MT1A MT2A MT1E MT1F | Copper homeostasis |
| KEGG:04978 | 4.19040395531e-09 | 1.0 | MT1A MT2A MT1E MT1F | Mineral absorption |
| GO:0071280 | 8.68316823302e-09 | 1.0 | MT1A MT2A MT1E MT1F | cellular response to copper ion |
| GO:0071294 | 8.68316823302e-09 | 1.0 | MT1A MT2A MT1E MT1F | cellular response to zinc ion |
| GO:0097501 | 8.68316823302e-09 | 1.0 | MT1A MT2A MT1E MT1F | stress response to metal ion |
| GO:0061687 | 1.30247523495e-08 | 1.0 | MT1A MT2A MT1E MT1F | detoxification of inorganic compound |
| GO:0046688 | 6.26240618018e-08 | 1.0 | MT1A MT2A MT1E MT1F | response to copper ion |
| GO:0010043 | 1.5748109659e-07 | 1.0 | MT1A MT2A MT1E MT1F | response to zinc ion |
| GO:0071276 | 1.92476895832e-07 | 1.0 | MT1A MT2A MT1E MT1F | cellular response to cadmium ion |
| GO:0046686 | 2.32998347586e-07 | 1.0 | MT1A MT2A MT1E MT1F | response to cadmium ion |
| GO:0006882 | 2.32998347586e-07 | 1.0 | MT1A MT2A MT1E MT1F | intracellular zinc ion homeostasis |
| GO:0098754 | 7.70499617526e-06 | 1.0 | MT1A MT2A MT1E MT1F | detoxification |
| GO:0009636 | 3.19816873601e-05 | 1.0 | MT1A MT2A MT1E MT1F | response to toxic substance |
| GO:0071248 | 0.000125780428129 | 1.0 | MT1A MT2A MT1E MT1F | cellular response to metal ion |
| GO:0071241 | 0.000208942050999 | 1.0 | MT1A MT2A MT1E MT1F | cellular response to inorganic substance |
| TF:M00650_1 | 0.000313494264121 | 0.75 | MT1F MT1E MT2A | Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 |
| GO:0045926 | 0.000439465274636 | 1.0 | MT1A MT2A MT1E MT1F | negative regulation of growth |
| GO:0010038 | 0.000745764165619 | 1.0 | MT1A MT2A MT1E MT1F | response to metal ion |
| REAC:R-HSA-8953897 | 0.00112698633356 | 1.0 | MT1A MT2A MT1E MT1F | Cellular responses to stimuli |
| GO:0010035 | 0.00366770658506 | 1.0 | MT1A MT2A MT1E MT1F | response to inorganic substance |
| GO:0008270 | 0.00749016343662 | 1.0 | MT1A MT2A MT1E MT1F | zinc ion binding |
| GO:0098771 | 0.00780772871207 | 1.0 | MT1A MT2A MT1E MT1F | inorganic ion homeostasis |
| GO:0030003 | 0.00980216551826 | 1.0 | MT1A MT2A MT1E MT1F | intracellular monoatomic cation homeostasis |
| GO:0006873 | 0.0101903286352 | 1.0 | MT1A MT2A MT1E MT1F | intracellular monoatomic ion homeostasis |
| GO:0040008 | 0.0138903594981 | 1.0 | MT1A MT2A MT1E MT1F | regulation of growth |
| GO:0055080 | 0.0145647397324 | 1.0 | MT1A MT2A MT1E MT1F | monoatomic cation homeostasis |
| GO:0050801 | 0.0156219824304 | 1.0 | MT1A MT2A MT1E MT1F | monoatomic ion homeostasis |
| GO:0055082 | 0.0270968554266 | 1.0 | MT1A MT2A MT1E MT1F | intracellular chemical homeostasis |
| GO:0046914 | 0.0290616669468 | 1.0 | MT1A MT2A MT1E MT1F | transition metal ion binding |
| GO:0040007 | 0.0339527319479 | 1.0 | MT1A MT2A MT1E MT1F | growth |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MT1A | MT2A | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MT2A | MT1E | 0.986 | 0.514 |
mutually_exclusive (P13640)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only |
| MT1A | MT1F | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MT1A | MT1E | 0.415 | bioplex3_WMM WMM_only |
Related Complexes