hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12772.1

Complex Portal: CPX-22837

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
EML5	Echinoderm microtubule-associated protein-like 5 (EMAP-5)	3	UniProt NCBI
STK3	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]	5	UniProt NCBI
PDCD4	Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)	5	UniProt NCBI
MLPH	Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)	5	UniProt NCBI
HIVEP1	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	5	UniProt NCBI
TRIM9	E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)	5	UniProt NCBI
RASSF3	Ras association domain-containing protein 3	5	UniProt NCBI
BTRC	F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)	5	UniProt NCBI
CDC25B	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	5	UniProt NCBI
CDC25A	M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)	5	UniProt NCBI
HIVEP2	Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2)	5	UniProt NCBI
RASSF2	Ras association domain-containing protein 2	5	UniProt NCBI
UBE2R2	Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)	5	UniProt NCBI
RASSF6	Ras association domain-containing protein 6	4	UniProt NCBI
TFAP4	Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)	5	UniProt NCBI
EGFLAM	Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)	5	UniProt NCBI
ACOT7	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (hBACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)	5	UniProt NCBI
STK4	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]	5	UniProt NCBI
NUDC	Nuclear migration protein nudC (Nuclear distribution protein C homolog)	5	UniProt NCBI
SLC25A43	Solute carrier family 25 member 43	3	UniProt NCBI
RASSF1	Ras association domain-containing protein 1	5	UniProt NCBI
FBXW11	F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)	5	UniProt NCBI
TRPV6	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)	5	UniProt NCBI
BHLHE40	Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)	5	UniProt NCBI
STARD8	StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)	5	UniProt NCBI
USP37	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)	5	UniProt NCBI
CDC34	Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04392	4.97612957986e-06	0.166666666667	STK3 RASSF6 RASSF1 RASSF2	Hippo signaling pathway - multiple species
KEGG:04390	0.000206571907523	0.208333333333	STK3 FBXW11 RASSF1 BTRC RASSF6	Hippo signaling pathway
CORUM:6716	0.000234715819577	0.0833333333333	STK3 STK4	DLG5-MST1-MST2 complex
KEGG:04710	0.00093560710278	0.125	BHLHE40 BTRC FBXW11	Circadian rhythm
WP:WP5087	0.00305595462593	0.25	STK3 RASSF2 RASSF6 BTRC RASSF3 RASSF1	Pleural mesothelioma
KEGG:04120	0.00390836402112	0.166666666667	UBE2R2 BTRC CDC34 FBXW11	Ubiquitin mediated proteolysis
REAC:R-HSA-983168	0.0243121538771	0.208333333333	UBE2R2 FBXW11 TRIM9 CDC34 BTRC	Antigen processing: Ubiquitination & Proteasome degradation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
STK4	RASSF1	1.0	0.132
BTRC	FBXW11	1.0	0.305047619048	structurally_consistent (dimer)
STK3	RASSF1	1.0	0.106
STK4	RASSF2	0.999	0.086	structurally_consistent (dimer)
STK4	STK3	0.999	0.266	mutually_exclusive (P50749)
UBE2R2	CDC34	0.999	0.186
STK3	RASSF2	0.999	0.108	structurally_consistent (dimer)
TFAP4	BTRC	0.999	0.216	structurally_consistent (dimer)
CDC25A	FBXW11	0.999
FBXW11	RASSF1	0.998	0.082
TFAP4	FBXW11	0.998	0.12	structurally_consistent (Q9Y297)
USP37	FBXW11	0.997	0.144
CDC25B	FBXW11	0.997	0.116
HIVEP2	FBXW11	0.997	0.166
BTRC	CDC34	0.995	0.122
BTRC	BHLHE40	0.994
BTRC	CDC25A	0.993
BTRC	HIVEP2	0.992	0.074
USP37	BTRC	0.992	0.25
BTRC	STK3	0.991	0.277863516566
BTRC	CDC25B	0.991	0.22
CDC34	FBXW11	0.99	0.026
FBXW11	NUDC	0.989	0.142
BTRC	HIVEP1	0.988	0.15
STK4	RASSF6	0.987
STK3	RASSF6	0.985
SLC25A43	TFAP4	0.978
BTRC	TRPV6	0.977
PDCD4	BTRC	0.973	0.142
BTRC	UBE2R2	0.971	0.152
FBXW11	STK4	0.969	0.078
RASSF3	BTRC	0.968	0.136865671642
BTRC	STARD8	0.968	0.132
BTRC	EGFLAM	0.963
BHLHE40	FBXW11	0.952
MLPH	BTRC	0.951	0.082
STARD8	FBXW11	0.896	0.078
FBXW11	STK3	0.881	0.106
PDCD4	FBXW11	0.873	0.048
BTRC	RASSF1	0.871	0.226
FBXW11	HIVEP1	0.869	0.098
HIVEP2	CDC25B	0.863	0.086
TFAP4	HIVEP1	0.861	0.102
TFAP4	HIVEP2	0.837	0.1
EML5	BTRC	0.836	0.14
RASSF3	STK3	0.834	0.104	mutually_exclusive (P50749)
TFAP4	BHLHE40	0.817
RASSF3	BHLHE40	0.814
USP37	BHLHE40	0.814
USP37	RASSF3	0.814	0.088
RASSF3	FBXW11	0.812	0.062
RASSF3	RASSF1	0.81	0.09
UBE2R2	FBXW11	0.809	0.054
CDC25B	ACOT7	0.807
HIVEP2	BHLHE40	0.806
HIVEP2	TRIM9	0.804
FBXW11	TRIM9	0.803
BTRC	NUDC	0.803	0.266
USP37	CDC34	0.782	0.092
TFAP4	USP37	0.776	0.162
TFAP4	RASSF3	0.768	0.066
RASSF3	HIVEP2	0.768	0.074
TFAP4	CDC34	0.768	0.058
HIVEP2	CDC34	0.768	0.036
BHLHE40	CDC34	0.768
RASSF3	CDC34	0.768	0.048
PDCD4	BHLHE40	0.768
BHLHE40	CDC25B	0.768
PDCD4	CDC34	0.763	0.098
PDCD4	HIVEP2	0.763	0.072
RASSF3	PDCD4	0.763	0.068
USP37	PDCD4	0.746	0.066
USP37	HIVEP2	0.685	0.108
USP37	CDC25B	0.675	0.136
TFAP4	PDCD4	0.663	0.096
CDC25B	CDC34	0.658	0.046
TFAP4	CDC25B	0.658	0.132
RASSF3	CDC25B	0.658	0.136
CDC34	ACOT7	0.652
PDCD4	CDC25B	0.651	0.118
HIVEP2	NUDC	0.645	0.066
HIVEP2	HIVEP1	0.626	0.056
BHLHE40	STK3	0.615
BHLHE40	NUDC	0.595
USP37	STK3	0.592	0.212
CDC25A	HIVEP1	0.59
EGFLAM	TRPV6	0.572
USP37	TRPV6	0.572
RASSF3	TRPV6	0.572
CDC34	STK3	0.566	0.094
TRPV6	BHLHE40	0.557
TFAP4	STK3	0.556	0.108
MLPH	TRPV6	0.516
RASSF3	NUDC	0.513	0.09
HIVEP2	STK3	0.512	0.028
TFAP4	TRPV6	0.502
TRPV6	CDC25A	0.502
TRPV6	RASSF1	0.502
TRPV6	CDC34	0.502
EML5	TRPV6	0.502
PDCD4	TRPV6	0.502
CDC25B	STK3	0.495	0.108
EGFLAM	FBXW11	0.485
CDC25B	CDC25A	0.475
BTRC	TRIM9	0.457
USP37	NUDC	0.435	0.306
CDC25B	HIVEP1	0.432	0.152
TFAP4	NUDC	0.432	0.088
BHLHE40	HIVEP1	0.37
TRPV6	ACOT7	0.357
TRPV6	TRIM9	0.35
HIVEP2	TRPV6	0.35
TRPV6	HIVEP1	0.35
TRPV6	CDC25B	0.35
USP37	EGFLAM	0.333
USP37	CDC25A	0.333
USP37	RASSF1	0.333	0.146
MLPH	FBXW11	0.317	0.074
PDCD4	HIVEP1	0.313	0.082
HIVEP2	CDC25A	0.304
RASSF3	HIVEP1	0.303	0.12
CDC34	HIVEP1	0.303	0.124
TRPV6	STK4	0.303
EGFLAM	BHLHE40	0.303
RASSF3	EGFLAM	0.303
CDC34	NUDC	0.291	0.16
MLPH	ACOT7	0.278
HIVEP1	ACOT7	0.274
HIVEP2	ACOT7	0.253
EGFLAM	STK3	0.252
PDCD4	ACOT7	0.25
PDCD4	STK3	0.235	0.038
RASSF3	STK4	0.228	0.056	mutually_exclusive (P50749) structurally_consistent (dimer)
TRPV6	NUDC	0.22
MLPH	STK4	0.213	0.07
USP37	HIVEP1	0.211	0.118
CDC25B	NUDC	0.202	0.134
BHLHE40	STK4	0.201
BHLHE40	ACOT7	0.2
MLPH	STK3	0.193	0.042
EGFLAM	STK4	0.187
CDC25A	STK4	0.187
EML5	STK4	0.187	0.07
TRPV6	FBXW11	0.187
MLPH	NUDC	0.182	0.05
CDC25B	STK4	0.176	0.146
TFAP4	STK4	0.176	0.074
CDC34	STK4	0.176	0.062
RASSF3	ACOT7	0.175
EGFLAM	ACOT7	0.175
CDC25A	ACOT7	0.175
CDC34	TRIM9	0.173
TFAP4	TRIM9	0.173
CDC25B	TRIM9	0.173
USP37	ACOT7	0.173
MLPH	CDC25A	0.172
BHLHE40	TRIM9	0.172
RASSF3	CDC25A	0.172
USP37	MLPH	0.172	0.082
MLPH	EGFLAM	0.172
EGFLAM	RASSF1	0.172
MLPH	RASSF1	0.172	0.116
BHLHE40	CDC25A	0.172
EML5	CDC25A	0.172
EML5	BHLHE40	0.172
EML5	RASSF3	0.172	0.118
EML5	USP37	0.172	0.094
BHLHE40	RASSF1	0.172
CDC25A	RASSF1	0.172
MLPH	RASSF3	0.172	0.122
EML5	RASSF1	0.172	0.084
EGFLAM	CDC25A	0.172
EML5	EGFLAM	0.172
ACOT7	RASSF1	0.169
MLPH	CDC34	0.164	0.028
EML5	CDC25B	0.164	0.128
CDC34	RASSF1	0.164	0.052
HIVEP2	RASSF1	0.164	0.092
HIVEP2	EGFLAM	0.164
HIVEP1	RASSF1	0.164	0.11
PDCD4	EGFLAM	0.164
TFAP4	EML5	0.164	0.106
TFAP4	MLPH	0.164	0.084
PDCD4	CDC25A	0.164
CDC25B	RASSF1	0.164	0.082
EML5	HIVEP1	0.164	0.074
TFAP4	RASSF1	0.164	0.104
MLPH	HIVEP1	0.164	0.084
CDC25A	CDC34	0.164
MLPH	TRIM9	0.164
MLPH	PDCD4	0.164	0.052
EML5	MLPH	0.164	0.104
EGFLAM	HIVEP1	0.164
TFAP4	CDC25A	0.164
EGFLAM	CDC25B	0.164
EGFLAM	CDC34	0.164
TFAP4	EGFLAM	0.164
MLPH	HIVEP2	0.164	0.072
EML5	HIVEP2	0.164	0.088
MLPH	CDC25B	0.164	0.072
EML5	CDC34	0.164	0.052
MLPH	BHLHE40	0.164
TFAP4	ACOT7	0.16
USP37	STK4	0.159	0.196
HIVEP1	STK4	0.152	0.064
BTRC	STK4	0.151	0.3
RASSF3	TRIM9	0.15
HIVEP2	STK4	0.145	0.022
EGFLAM	TRIM9	0.143
TRIM9	RASSF1	0.143
EML5	PDCD4	0.143	0.074
EML5	TRIM9	0.143
TRPV6	STK3	0.143
PDCD4	RASSF1	0.143	0.064
CDC25A	TRIM9	0.143
EML5	FBXW11	0.143	0.074
EML5	STK3	0.141	0.032
HIVEP1	STK3	0.14	0.092
CDC25A	STK3	0.14
EML5	ACOT7	0.138
USP37	TRIM9	0.119
UBE2R2	STK4	0.115	0.024
RASSF3	UBE2R2	0.11	0.06
MLPH	UBE2R2	0.11	0.058
BHLHE40	UBE2R2	0.11
CDC25A	UBE2R2	0.11
TFAP4	UBE2R2	0.11	0.052
UBE2R2	HIVEP1	0.11	0.09
HIVEP2	UBE2R2	0.11	0.014
CDC25B	UBE2R2	0.11	0.064
EML5	UBE2R2	0.11	0.088
USP37	UBE2R2	0.11	0.052
EGFLAM	UBE2R2	0.11
TRPV6	UBE2R2	0.11
EML5	NUDC	0.101	0.082
UBE2R2	TRIM9	0.095
PDCD4	UBE2R2	0.095	0.044
UBE2R2	RASSF1	0.095	0.08
NUDC	HIVEP1	0.093	0.132
UBE2R2	STK3	0.092	0.014
UBE2R2	ACOT7	0.084
CDC25A	NUDC	0.083
NUDC	RASSF1	0.074	0.124
TRIM9	STK3	0.066
PDCD4	STK4	0.063	0.052
EGFLAM	NUDC	0.053
BTRC	ACOT7	0.051
TRIM9	HIVEP1	0.05
PDCD4	NUDC	0.044	0.088
NUDC	RASSF6	0.038
TRIM9	STK4	0.038
UBE2R2	NUDC	0.018	0.058
PDCD4	TRIM9	0.015
PDCD4	RASSF2	0.012	0.014
TRIM9	ACOT7	0.011
STK3	ACOT7	0.011
RASSF2	ACOT7	0.009
NUDC	RASSF2	0.009	0.052
NUDC	STK3	0.009	0.048
NUDC	TRIM9	0.008
TRIM9	RASSF2	0.008
STK4	ACOT7	0.006
FBXW11	ACOT7	0.004
NUDC	STK4	0.003	0.02
NUDC	ACOT7	0.002

Related Complexes

Genename	Complexes
EML5	huMAP3_00192.1 huMAP3_01215.1 huMAP3_08378.1 huMAP3_09922.1 huMAP3_12772.1
STK3	huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1
PDCD4	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05184.1 huMAP3_05920.1 huMAP3_07165.1 huMAP3_07521.1 huMAP3_07691.1 huMAP3_08042.1 huMAP3_10829.1 huMAP3_11945.1 huMAP3_12772.1 huMAP3_13776.1
MLPH	huMAP3_01476.1 huMAP3_07691.1 huMAP3_12772.1 huMAP3_14986.1
HIVEP1	huMAP3_04087.1 huMAP3_07838.1 huMAP3_08154.1 huMAP3_09810.1 huMAP3_11570.1 huMAP3_12772.1 huMAP3_15164.1
TRIM9	huMAP3_03552.1 huMAP3_06540.1 huMAP3_12772.1
RASSF3	huMAP3_01602.1 huMAP3_04903.1 huMAP3_07687.1 huMAP3_07691.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12772.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_15155.1
BTRC	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05920.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1
CDC25B	huMAP3_03088.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07002.1 huMAP3_07596.1 huMAP3_07691.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12897.1
CDC25A	huMAP3_03088.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1
HIVEP2	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05920.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12961.1
RASSF2	huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1
UBE2R2	huMAP3_03088.1 huMAP3_03868.1 huMAP3_04044.1 huMAP3_05733.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07489.1 huMAP3_07691.1 huMAP3_10453.1 huMAP3_10829.1 huMAP3_12112.1 huMAP3_12772.1 huMAP3_14608.1
RASSF6	huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1 huMAP3_13091.1
TFAP4	huMAP3_00181.1 huMAP3_03088.1 huMAP3_06177.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12961.1
EGFLAM	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05920.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_13917.1 huMAP3_14149.1
ACOT7	huMAP3_05184.1 huMAP3_07165.1 huMAP3_07521.1 huMAP3_08042.1 huMAP3_12772.1 huMAP3_14193.1
STK4	huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1
NUDC	huMAP3_03340.1 huMAP3_04811.1 huMAP3_05059.1 huMAP3_06177.1 huMAP3_06543.1 huMAP3_07691.1 huMAP3_10784.1 huMAP3_10829.1 huMAP3_12772.1
SLC25A43	huMAP3_00181.1 huMAP3_02041.1 huMAP3_03466.1 huMAP3_10138.1 huMAP3_11938.1 huMAP3_12772.1 huMAP3_12961.1
RASSF1	huMAP3_10317.1 huMAP3_11472.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12772.1 huMAP3_13169.1 huMAP3_14729.1
FBXW11	huMAP3_03340.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1
TRPV6	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05920.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1
BHLHE40	huMAP3_01602.1 huMAP3_03088.1 huMAP3_05920.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_15155.1
STARD8	huMAP3_01602.1 huMAP3_03088.1 huMAP3_03768.1 huMAP3_07691.1 huMAP3_10829.1 huMAP3_12772.1
USP37	huMAP3_00732.1 huMAP3_01602.1 huMAP3_03088.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07079.1 huMAP3_07691.1 huMAP3_09021.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_13744.1 huMAP3_15155.1
CDC34	huMAP3_03088.1 huMAP3_03868.1 huMAP3_04044.1 huMAP3_06177.1 huMAP3_07002.1 huMAP3_07691.1 huMAP3_10453.1 huMAP3_10829.1 huMAP3_12112.1 huMAP3_12772.1 huMAP3_14608.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12772.1

Complex Portal: CPX-22837