hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12775.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GATM | Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase) | 5 | UniProt NCBI |
| PTGR3 | Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2) | 4 | UniProt NCBI |
| DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) | 5 | UniProt NCBI |
| LIPT1 | Lipoyl amidotransferase LIPT1, mitochondrial (EC 2.3.1.200) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyltransferase 1) (EC 2.3.1.-) | 5 | UniProt NCBI |
| PPM1K | Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial) | 5 | UniProt NCBI |
| MCEE | Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0004354 | 0.000407927807562 | 0.8 | LIPT1 GATM MCEE PPM1K | Abnormal circulating carboxylic acid concentration |
| HP:0033107 | 0.00148214139581 | 0.6 | LIPT1 MCEE PPM1K | Abnormal circulating proteinogenic amino acid concentration |
| HP:0012072 | 0.00273423564762 | 0.6 | LIPT1 GATM MCEE | Aciduria |
| HP:0032943 | 0.00288838076992 | 0.6 | LIPT1 GATM MCEE | Abnormal urine pH |
| HP:0003112 | 0.00686727647703 | 0.6 | LIPT1 MCEE PPM1K | Abnormal circulating amino acid concentration |
| HP:0010966 | 0.0161800923797 | 0.4 | GATM MCEE | Abnormal circulating fatty-acid anion concentration |
| REAC:R-HSA-71291 | 0.0166452724524 | 0.6 | LIPT1 GATM PPM1K | Metabolism of amino acids and derivatives |
| HP:0003648 | 0.0176485923371 | 0.4 | LIPT1 GATM | Lacticaciduria |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PTGR3 | DBT | 0.984 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| LIPT1 | DBT | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MCEE | DBT | 0.966 | 0.358 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction |
| GATM | DBT | 0.821 | 0.124 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| DBT | PPM1K | 0.801 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
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