hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12776.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDSS1 | All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) | 5 | UniProt NCBI |
| ALAS1 | 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) | 5 | UniProt NCBI |
| FPGS | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | 5 | UniProt NCBI |
| THEM4 | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) | 5 | UniProt NCBI |
| PDSS2 | All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5037 | 0.000168398502686 | 0.5 | PDSS1 PDSS2 | Riboflavin and CoQ disorders |
| REAC:R-HSA-2142789 | 0.000215205765992 | 0.5 | PDSS1 PDSS2 | Ubiquinol biosynthesis |
| KEGG:00900 | 0.000578341586214 | 0.5 | PDSS1 PDSS2 | Terpenoid backbone biosynthesis |
| REAC:R-HSA-8978934 | 0.00122873738811 | 0.5 | PDSS1 PDSS2 | Metabolism of cofactors |
| GO:0000010 | 0.0028092043205 | 0.5 | PDSS1 PDSS2 | trans-hexaprenyltranstransferase activity |
| GO:0097269 | 0.0028092043205 | 0.5 | PDSS1 PDSS2 | all-trans-decaprenyl-diphosphate synthase activity |
| GO:0005759 | 0.0284897407301 | 1.0 | PDSS1 PDSS2 FPGS THEM4 | mitochondrial matrix |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| THEM4 | PDSS2 | 0.974 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ALAS1 | THEM4 | 0.961 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| FPGS | THEM4 | 0.944 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDSS1 | THEM4 | 0.932 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FPGS | ALAS1 | 0.929 | 0.18 | bioplex_WMM bioplex3_WMM WMM_only |
| PDSS1 | PDSS2 | 0.744 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
| ALAS1 | PDSS2 | 0.52 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
| FPGS | PDSS2 | 0.159 | 0.162 | bioplex_WMM bioplex3_WMM WMM_only |
| FPGS | PDSS1 | 0.154 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| ALAS1 | PDSS1 | 0.082 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes