List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_12787.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RAD9A	Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A)	5	UniProt   NCBI
HUS1	Checkpoint protein HUS1 (hHUS1)	5	UniProt   NCBI
RAD1	Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)	5	UniProt   NCBI
RAD17	Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)	5	UniProt   NCBI
HUS1B	Checkpoint protein HUS1B (hHUS1B)	3	UniProt   NCBI
ZBTB14	Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5)	5	UniProt   NCBI
RHNO1	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6728	1.92263483365e-12	0.571428571429	HUS1 RHNO1 RAD9A RAD1	9-1-1-RHINO complex
CORUM:268	1.34496026232e-10	0.571428571429	HUS1 RAD17 RAD9A RAD1	9-1-1-RAD17-RFC complex
CORUM:274	1.34496026232e-10	0.571428571429	HUS1 RAD17 RAD9A RAD1	9-1-1-RAD17-RFC complex
REAC:R-HSA-9709570	2.03264024031e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Impaired BRCA2 binding to RAD51
REAC:R-HSA-5685938	2.3711426543e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-5693616	4.20346129105e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9701190	4.80340670548e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
REAC:R-HSA-9675136	4.80340670548e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Diseases of DNA Double-Strand Break Repair
REAC:R-HSA-5693579	6.20839006435e-10	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Homologous DNA Pairing and Strand Exchange
GO:0030896	9.2094208532e-10	0.571428571429	HUS1 HUS1B RAD9A RAD1	checkpoint clamp complex
REAC:R-HSA-9675135	1.39057873035e-09	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Diseases of DNA repair
REAC:R-HSA-5685942	6.50451399979e-09	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	HDR through Homologous Recombination (HRR)
CORUM:271	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1 complex
CORUM:267	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1 complex
CORUM:2809	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1 complex
CORUM:276	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1 complex
CORUM:2196	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1-LIG1 complex
CORUM:275	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1 complex
CORUM:2808	7.02338504734e-09	0.428571428571	HUS1 RAD9A RAD1	9-1-1-APE1 complex
REAC:R-HSA-69473	2.6828400616e-08	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	G2/M DNA damage checkpoint
CORUM:2197	2.80877722849e-08	0.428571428571	HUS1 RAD9A RAD1	9-1-1-FEN1 complex
CORUM:2198	2.80877722849e-08	0.428571428571	HUS1 RAD9A RAD1	9-1-1-POLB complex
REAC:R-HSA-6804756	3.01307912354e-08	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Regulation of TP53 Activity through Phosphorylation
REAC:R-HSA-5693607	3.18995342802e-08	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Processing of DNA double-strand break ends
GO:0000077	4.38987933769e-08	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	DNA damage checkpoint signaling
GO:0031570	7.23684693468e-08	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	DNA integrity checkpoint signaling
REAC:R-HSA-5693567	1.56237670602e-07	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-5693538	1.98880370917e-07	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Homology Directed Repair
REAC:R-HSA-176187	2.09160668344e-07	0.571428571429	HUS1 RAD17 RAD9A RAD1	Activation of ATR in response to replication stress
WP:WP3875	3.40945554709e-07	0.428571428571	HUS1 RAD9A RAD1	ATR signaling
GO:0042770	4.1400936744e-07	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	signal transduction in response to DNA damage
GO:0031573	4.5526752727e-07	0.571428571429	HUS1 HUS1B RAD9A RAD17	mitotic intra-S DNA damage checkpoint signaling
REAC:R-HSA-5633007	4.55952496599e-07	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Regulation of TP53 Activity
REAC:R-HSA-5693532	5.54362467035e-07	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	DNA Double-Strand Break Repair
REAC:R-HSA-69481	5.72295397008e-07	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	G2/M Checkpoints
GO:0000075	6.31779582926e-07	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	cell cycle checkpoint signaling
WP:WP707	1.11827620272e-06	0.571428571429	RAD1 HUS1B RAD9A RAD17	DNA damage response
WP:WP1530	1.11827620272e-06	0.571428571429	RAD1 HUS1B RAD9A RAD17	miRNA regulation of DNA damage response
WP:WP4016	2.23080614543e-06	0.571428571429	HUS1 RAD17 RAD9A RAD1	DNA IR damage and cellular response via ATR
GO:1901988	2.30814795901e-06	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	negative regulation of cell cycle phase transition
GO:0000076	2.81160701714e-06	0.571428571429	HUS1 HUS1B RAD9A RAD17	DNA replication checkpoint signaling
GO:0010948	5.89634003472e-06	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	negative regulation of cell cycle process
REAC:R-HSA-69620	9.65081422811e-06	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Cell Cycle Checkpoints
REAC:R-HSA-73894	1.53171683772e-05	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	DNA Repair
CORUM:6734	2.05265451394e-05	0.285714285714	RAD1 HUS1B	9b-1b-1 complex
CORUM:6733	2.05265451394e-05	0.285714285714	HUS1 RAD1	9b-1-1 complex
REAC:R-HSA-3700989	2.51708257586e-05	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Transcriptional Regulation by TP53
GO:0045786	2.54947562279e-05	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	negative regulation of cell cycle
GO:1901987	5.30174259234e-05	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	regulation of cell cycle phase transition
GO:0000794	0.000149249561323	0.571428571429	HUS1 HUS1B RAD9A RAD1	condensed nuclear chromosome
GO:0033313	0.0001882019462	0.428571428571	HUS1 HUS1B RAD1	meiotic cell cycle checkpoint signaling
GO:0044770	0.000188437136259	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	cell cycle phase transition
GO:0071479	0.000228371329052	0.571428571429	HUS1 RHNO1 RAD9A RAD1	cellular response to ionizing radiation
GO:0006281	0.000435439962474	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	DNA repair
GO:0033314	0.000554182028596	0.428571428571	HUS1 RAD17 HUS1B	mitotic DNA replication checkpoint signaling
REAC:R-HSA-1640170	0.000632818805842	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Cell Cycle
GO:0044773	0.000835286748042	0.571428571429	HUS1 HUS1B RAD9A RAD17	mitotic DNA damage checkpoint signaling
GO:0010564	0.000968468780745	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	regulation of cell cycle process
GO:0044774	0.0010475236298	0.571428571429	HUS1 HUS1B RAD9A RAD17	mitotic DNA integrity checkpoint signaling
KEGG:04218	0.00152804474169	0.428571428571	HUS1 RAD9A RAD1	Cellular senescence
GO:0010212	0.0018400127105	0.571428571429	HUS1 RHNO1 RAD9A RAD1	response to ionizing radiation
GO:0006974	0.00462209623318	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	DNA damage response
REAC:R-HSA-212436	0.00607059142443	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Generic Transcription Pathway
GO:0006259	0.00669848388987	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	DNA metabolic process
GO:0007093	0.0084704456326	0.571428571429	HUS1 HUS1B RAD9A RAD17	mitotic cell cycle checkpoint signaling
GO:0044778	0.00983221512175	0.285714285714	HUS1 HUS1B	meiotic DNA integrity checkpoint signaling
GO:0051726	0.0100706914797	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	regulation of cell cycle
REAC:R-HSA-73857	0.0103732213005	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	RNA Polymerase II Transcription
GO:0071478	0.0105668632889	0.571428571429	HUS1 RHNO1 RAD9A RAD1	cellular response to radiation
REAC:R-HSA-74160	0.0190899982826	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Gene expression (Transcription)
WP:WP3959	0.0233506622299	0.285714285714	RAD9A RAD17	DNA IR double strand breaks and cellular response via ATM
GO:0022402	0.0295707017041	0.857142857143	RHNO1 RAD17 HUS1B RAD1 HUS1 RAD9A	cell cycle process
GO:0000228	0.0322799316792	0.571428571429	HUS1 HUS1B RAD9A RAD1	nuclear chromosome
REAC:R-HSA-1643685	0.0367346572641	0.714285714286	HUS1 RAD17 RHNO1 RAD9A RAD1	Disease
GO:0045930	0.0395494837294	0.571428571429	HUS1 HUS1B RAD9A RAD17	negative regulation of mitotic cell cycle



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
HUS1	RAD1	1.0	0.666	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RAD9A	RAD1	1.0	0.186	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RAD1	ZBTB14	1.0	0.144	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RAD9A	HUS1B	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RAD1	HUS1B	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RAD9A	HUS1	0.999	0.272	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HUS1B	ZBTB14	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
RAD17	HUS1	0.994	0.212	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
HUS1	ZBTB14	0.994	0.09	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
RAD9A	ZBTB14	0.993	0.09	bioplex_WMM     bioplex3_WMM     WMM_only
RAD17	RAD1	0.99	0.112	bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     WMM_only
RAD1	RHNO1	0.989		bioplex3_HEK293     bioplex3_WMM     WMM_only
RAD17	RAD9A	0.939	0.176	bioplex_WMM     bioplex3_WMM     WMM_only
RAD17	ZBTB14	0.86	0.09	bioplex_WMM     bioplex3_WMM     WMM_only
HUS1	RHNO1	0.582		bioplex3_HEK293     bioplex3_WMM     WMM_only
HUS1	HUS1B	0.401		bioplex3_WMM     WMM_only
RAD17	HUS1B	0.162		bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
RAD9A	huMAP3_01448.1 huMAP3_01683.1 huMAP3_05223.1 huMAP3_09595.1 huMAP3_12787.1 huMAP3_13983.1
HUS1	huMAP3_01448.1 huMAP3_01683.1 huMAP3_09595.1 huMAP3_12787.1
RAD1	huMAP3_01448.1 huMAP3_01683.1 huMAP3_05223.1 huMAP3_09595.1 huMAP3_12787.1 huMAP3_13983.1
RAD17	huMAP3_00703.1 huMAP3_01448.1 huMAP3_02396.1 huMAP3_02854.1 huMAP3_03241.1 huMAP3_07313.1 huMAP3_08854.1 huMAP3_08879.1 huMAP3_10568.1 huMAP3_12787.1
HUS1B	huMAP3_01448.1 huMAP3_05223.1 huMAP3_09595.1 huMAP3_12787.1 huMAP3_13983.1
ZBTB14	huMAP3_01448.1 huMAP3_01683.1 huMAP3_05223.1 huMAP3_09595.1 huMAP3_12787.1 huMAP3_13983.1
RHNO1	huMAP3_03161.1 huMAP3_05223.1 huMAP3_12787.1