hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12795.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRELD1 | Protein disulfide isomerase CRELD1 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 1) | 5 | UniProt NCBI |
| SCN9A | Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) | 5 | UniProt NCBI |
| ORMDL3 | ORM1-like protein 3 | 5 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
| TMEM14C | Transmembrane protein 14C | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660661 | 0.00849065158197 | 0.4 | ORMDL3 ORMDL2 | Sphingolipid de novo biosynthesis |
| GO:0035339 | 0.0280843539964 | 0.4 | ORMDL3 ORMDL2 | SPOTS complex |
| GO:0090156 | 0.0280843539964 | 0.4 | ORMDL3 ORMDL2 | intracellular sphingolipid homeostasis |
| REAC:R-HSA-428157 | 0.0395622673154 | 0.4 | ORMDL3 ORMDL2 | Sphingolipid metabolism |
| GO:1900060 | 0.0468008499735 | 0.4 | ORMDL3 ORMDL2 | negative regulation of ceramide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORMDL2 | ORMDL3 | 0.988 | 0.262 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CRELD1 | SCN9A | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORMDL2 | CRELD1 | 0.918 | 0.074 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CRELD1 | TMEM14C | 0.894 | 0.068 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CRELD1 | ORMDL3 | 0.865 | 0.136 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SCN9A | TMEM14C | 0.415 | bioplex3_WMM WMM_only | |
| SCN9A | ORMDL3 | 0.21 | bioplex3_WMM WMM_only | |
| ORMDL2 | SCN9A | 0.113 | bioplex3_WMM WMM_only | |
| ORMDL3 | TMEM14C | 0.078 | 0.056 | bioplex3_WMM WMM_only |
| ORMDL2 | TMEM14C | 0.076 | 0.12 | bioplex3_WMM WMM_only |
Related Complexes