hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12796.1
Complex Portal: CPX-19299
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PKDCC | Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase) | 5 | UniProt NCBI |
| GPC2 | Glypican-2 [Cleaved into: Secreted glypican-2] | 5 | UniProt NCBI |
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | 5 | UniProt NCBI |
| CLEC12B | C-type lectin domain family 12 member B (Macrophage antigen H) | 5 | UniProt NCBI |
| TP53I13 | Tumor protein p53-inducible protein 13 (Damage-stimulated cytoplasmic protein 1) | 4 | UniProt NCBI |
| COQ2 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (4-hydroxybenzoate decaprenyltransferase) (COQ2 homolog) (hCOQ2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase) | 5 | UniProt NCBI |
| GASK1A | Golgi-associated kinase 1A (Protein FAM198A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 0.00345846977329 | 0.285714285714 | GPC2 GPC6 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.00345846977329 | 0.285714285714 | GPC2 GPC6 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-9694614 | 0.00516516478082 | 0.285714285714 | GPC2 GPC6 | Attachment and Entry |
| REAC:R-HSA-4420332 | 0.00580948443663 | 0.285714285714 | GPC2 GPC6 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.00580948443663 | 0.285714285714 | GPC2 GPC6 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 0.00580948443663 | 0.285714285714 | GPC2 GPC6 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-196854 | 0.00799265153172 | 0.428571428571 | GPC2 COQ2 GPC6 | Metabolism of vitamins and cofactors |
| REAC:R-HSA-2024096 | 0.0087631788483 | 0.285714285714 | GPC2 GPC6 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.0104655132242 | 0.285714285714 | GPC2 GPC6 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.0143201223364 | 0.285714285714 | GPC2 GPC6 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 0.0199798926111 | 0.285714285714 | GPC2 GPC6 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 0.0265716665994 | 0.285714285714 | GPC2 GPC6 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.0294686169459 | 0.285714285714 | GPC2 GPC6 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.0340922297215 | 0.285714285714 | GPC2 GPC6 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.0390490515953 | 0.285714285714 | GPC2 GPC6 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.0461752771557 | 0.285714285714 | GPC2 GPC6 | Heparan sulfate/heparin (HS-GAG) metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PKDCC | CLEC12B | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CLEC12B | TP53I13 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GPC2 | CLEC12B | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CLEC12B | GASK1A | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CLEC12B | GPC6 | 0.854 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GPC2 | GPC6 | 0.283 | 0.056 | bioplex3_WMM WMM_only | |
| PKDCC | GPC2 | 0.25 | bioplex3_WMM WMM_only | ||
| PKDCC | TP53I13 | 0.25 | bioplex3_WMM WMM_only | ||
| TP53I13 | GPC6 | 0.102 | bioplex3_WMM WMM_only | ||
| PKDCC | GPC6 | 0.102 | bioplex3_WMM WMM_only | ||
| GPC2 | TP53I13 | 0.095 | bioplex3_WMM WMM_only | ||
| PKDCC | GASK1A | 0.095 | bioplex3_WMM WMM_only | ||
| TP53I13 | GASK1A | 0.076 | bioplex3_WMM WMM_only | ||
| GPC2 | GASK1A | 0.076 | bioplex3_WMM WMM_only | ||
| GPC6 | GASK1A | 0.056 | bioplex3_WMM WMM_only |
Related Complexes