hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12802.1
Complex Portal: CPX-21886
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLPPR3 | Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) | 4 | UniProt NCBI |
| RBIS | Ribosomal biogenesis factor | 4 | UniProt NCBI |
| PLPPR4 | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | 5 | UniProt NCBI |
| PLPPR1 | Phospholipid phosphatase-related protein type 1 (Inactive 2-lysophosphatidate phosphatase PLPPR1) (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-419408 | 2.31434954766e-07 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | Lysosphingolipid and LPA receptors |
| GO:0008195 | 8.45465618902e-05 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | phosphatidate phosphatase activity |
| GO:0042577 | 0.000215165225046 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | lipid phosphatase activity |
| REAC:R-HSA-373076 | 0.000722417813202 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | Class A/1 (Rhodopsin-like receptors) |
| REAC:R-HSA-500792 | 0.00273968747995 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | GPCR ligand binding |
| REAC:R-HSA-372790 | 0.0165968987372 | 0.75 | PLPPR1 PLPPR3 PLPPR4 | Signaling by GPCR |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLPPR4 | PLPPR1 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLPPR3 | PLPPR1 | 0.988 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLPPR1 | RBIS | 0.946 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PLPPR4 | RBIS | 0.165 | 0.076 | bioplex3_WMM WMM_only | |
| PLPPR3 | PLPPR4 | 0.043 |
mutually_exclusive (Q8TBJ4)
|
bioplex3_WMM WMM_only | |
| PLPPR3 | RBIS | 0.023 | bioplex3_WMM WMM_only |
Related Complexes