hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12823.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP1R14B | Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein) | 3 | UniProt NCBI |
| HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | 5 | UniProt NCBI |
| PKM | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | 5 | UniProt NCBI |
| PPA1 | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | 4 | UniProt NCBI |
| GMPS | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | 5 | UniProt NCBI |
| MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | 5 | UniProt NCBI |
| ATIC | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73817 | 0.000835043279679 | 0.4 | ATIC GMPS | Purine ribonucleoside monophosphate biosynthesis |
| REAC:R-HSA-8956320 | 0.0013810496636 | 0.4 | ATIC GMPS | Nucleotide biosynthesis |
| HPA:0641513 | 0.00263309027148 | 0.4 | ATIC PPA1 | endometrium; nonciliated glandular epithelial cells[High] |
| HPA:0641523 | 0.00306164759471 | 0.4 | ATIC PPA1 | endometrium; nonciliated luminal epithelial cells[High] |
| HPA:0641532 | 0.00481464032182 | 0.4 | ATIC PPA1 | endometrium; stromal fibroblasts[>=Medium] |
| HPA:0640202 | 0.00481464032182 | 0.4 | ATIC PPA1 | endometrium; endothelial cells[>=Medium] |
| HPA:0640201 | 0.00538768366829 | 0.4 | ATIC PPA1 | endometrium; endothelial cells[>=Low] |
| HPA:0641503 | 0.00568622014719 | 0.4 | ATIC PPA1 | endometrium; ciliated epithelial cells[High] |
| HPA:0641512 | 0.00568622014719 | 0.4 | ATIC PPA1 | endometrium; nonciliated glandular epithelial cells[>=Medium] |
| HPA:0641522 | 0.00568622014719 | 0.4 | ATIC PPA1 | endometrium; nonciliated luminal epithelial cells[>=Medium] |
| HPA:0640692 | 0.00568622014719 | 0.4 | ATIC PPA1 | endometrium; smooth muscle cells[>=Medium] |
| HPA:0641531 | 0.00599276207912 | 0.4 | ATIC PPA1 | endometrium; stromal fibroblasts[>=Low] |
| HPA:0641511 | 0.00911133856759 | 0.4 | ATIC PPA1 | endometrium; nonciliated glandular epithelial cells[>=Low] |
| HPA:0641521 | 0.00989213643332 | 0.4 | ATIC PPA1 | endometrium; nonciliated luminal epithelial cells[>=Low] |
| HPA:0640691 | 0.0102944856463 | 0.4 | ATIC PPA1 | endometrium; smooth muscle cells[>=Low] |
| HPA:0641502 | 0.010704797307 | 0.4 | ATIC PPA1 | endometrium; ciliated epithelial cells[>=Medium] |
| HPA:0641501 | 0.0157428028711 | 0.4 | ATIC PPA1 | endometrium; ciliated epithelial cells[>=Low] |
| HPA:0471473 | 0.0212982616684 | 0.6 | HADH PPA1 ATIC | skin 2; lymphocytes[High] |
| KEGG:00230 | 0.0213229262457 | 0.4 | ATIC GMPS | Purine metabolism |
| HPA:0160053 | 0.0294062598088 | 0.8 | PPP1R14B ATIC PPA1 HADH | endometrium 1; glandular cells[High] |
| HPA:0640000 | 0.0343425608627 | 0.4 | ATIC PPA1 | endometrium |
| HPA:0360053 | 0.035740890287 | 0.8 | PPP1R14B ATIC PPA1 HADH | parathyroid gland; glandular cells[High] |
| HPA:0471482 | 0.0421117138818 | 0.4 | ATIC PPA1 | skin 2; sebaceous glands[>=Medium] |
| REAC:R-HSA-15869 | 0.0440242300692 | 0.4 | ATIC GMPS | Metabolism of nucleotides |
| HPA:0460202 | 0.0460879152407 | 0.6 | HADH PPA1 ATIC | skin 1; endothelial cells[>=Medium] |
| HPA:0210053 | 0.0468804820557 | 0.8 | PPP1R14B ATIC PPA1 HADH | fallopian tube; glandular cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PPA1 | ATIC | 0.981 | 0.254 | bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GMPS | HADH | 0.936 | 0.076 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
| GMPS | PKM | 0.919 | 0.43 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction treiber_WMM |
| PPA1 | GMPS | 0.889 | 0.334 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| PPA1 | PPP1R14B | 0.878 | 0.178 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ATIC | GMPS | 0.868 | 0.384 | bioplex_WMM bioplex3_WMM gupta_WMM fraction treiber_WMM |
| PKM | MTHFD1 | 0.852 | 0.534 | bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| GMPS | MTHFD1 | 0.829 | 0.274 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| PPA1 | HADH | 0.809 | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM |
| HADH | PPP1R14B | 0.696 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only |
| ATIC | HADH | 0.61 | 0.12 | bioplex_WMM bioplex3_WMM fraction |
| PPA1 | PKM | 0.513 | 0.47 | bioplex_WMM bioplex3_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| ATIC | PPP1R14B | 0.296 | 0.12 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PPA1 | MTHFD1 | 0.238 | 0.368 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| ATIC | MTHFD1 | 0.128 | 0.382 | bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GMPS | PPP1R14B | 0.103 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| HADH | MTHFD1 | 0.059 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
| ATIC | PKM | 0.038 | 0.652 | bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| HADH | PKM | 0.035 | 0.222989328063 | bioplex_WMM bioplex3_WMM fraction treiber_WMM |
| PPP1R14B | MTHFD1 | 0.028 | 0.15 | bioplex3_WMM WMM_only |
| PPP1R14B | PKM | 0.005 | 0.158405797101 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes