hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12824.1
Complex Portal: CPX-17018
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FGF2 | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | 5 | UniProt NCBI |
| IL7R | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) | 5 | UniProt NCBI |
| DHRS2 | Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1) | 5 | UniProt NCBI |
| METTL8 | tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-) | 5 | UniProt NCBI |
| USF3 | Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3) | 5 | UniProt NCBI |
| GMEB2 | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | 5 | UniProt NCBI |
| GMEB1 | Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) | 5 | UniProt NCBI |
| SDC4 | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | 5 | UniProt NCBI |
| AMPD2 | AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) | 5 | UniProt NCBI |
| SDC1 | Syndecan-1 (SYND1) (CD antigen CD138) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3000170 | 5.85853615136e-05 | 0.333333333333 | SDC1 FGF2 SDC4 | Syndecan interactions |
| REAC:R-HSA-3000171 | 0.000652728146316 | 0.333333333333 | SDC1 FGF2 SDC4 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3656253 | 0.00724150508664 | 0.222222222222 | SDC1 SDC4 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.00724150508664 | 0.222222222222 | SDC1 SDC4 | Defective EXT2 causes exostoses 2 |
| KEGG:05205 | 0.00763397577415 | 0.333333333333 | SDC1 FGF2 SDC4 | Proteoglycans in cancer |
| REAC:R-HSA-9694614 | 0.0108121024449 | 0.222222222222 | SDC1 SDC4 | Attachment and Entry |
| REAC:R-HSA-4420332 | 0.0121597301349 | 0.222222222222 | SDC1 SDC4 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.0121597301349 | 0.222222222222 | SDC1 SDC4 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 0.0121597301349 | 0.222222222222 | SDC1 SDC4 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-2024096 | 0.0183353632609 | 0.222222222222 | SDC1 SDC4 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.0218931941247 | 0.222222222222 | SDC1 SDC4 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.0299458635385 | 0.222222222222 | SDC1 SDC4 | HS-GAG biosynthesis |
| KEGG:04512 | 0.0369068821541 | 0.222222222222 | SDC1 SDC4 | ECM-receptor interaction |
| REAC:R-HSA-9772572 | 0.0417623735111 | 0.222222222222 | SDC1 SDC4 | Early SARS-CoV-2 Infection Events |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GMEB2 | GMEB1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | ||
| SDC1 | FGF2 | 0.994 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SDC1 | DHRS2 | 0.994 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FGF2 | GMEB2 | 0.992 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| FGF2 | GMEB1 | 0.992 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| FGF2 | DHRS2 | 0.99 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| FGF2 | IL7R | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SDC1 | GMEB2 | 0.984 | 0.0844222222222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GMEB2 | DHRS2 | 0.982 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| GMEB1 | DHRS2 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GMEB2 | SDC4 | 0.974 | 0.12 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| FGF2 | SDC4 | 0.966 | 0.108 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| GMEB1 | SDC4 | 0.951 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SDC4 | DHRS2 | 0.946 | 0.024 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| METTL8 | SDC4 | 0.936 | 0.072 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IL7R | GMEB1 | 0.92 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SDC1 | SDC4 | 0.907 | 0.204 | bioplex_WMM bioplex3_WMM WMM_only | |
| USF3 | METTL8 | 0.904 | bioplex3_WMM WMM_only | ||
| USF3 | GMEB1 | 0.904 | bioplex3_WMM WMM_only | ||
| USF3 | FGF2 | 0.902 | bioplex3_WMM WMM_only | ||
| USF3 | GMEB2 | 0.902 | bioplex3_WMM WMM_only | ||
| METTL8 | GMEB2 | 0.9 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| IL7R | DHRS2 | 0.892 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AMPD2 | SDC4 | 0.887 | 0.138 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IL7R | GMEB2 | 0.881 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AMPD2 | GMEB2 | 0.879 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| USF3 | DHRS2 | 0.869 | bioplex3_WMM WMM_only | ||
| METTL8 | DHRS2 | 0.867 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| METTL8 | GMEB1 | 0.863 | bioplex_WMM bioplex3_WMM WMM_only | ||
| METTL8 | FGF2 | 0.854 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| SDC1 | GMEB1 | 0.847 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AMPD2 | FGF2 | 0.839 | 0.0722197802198 | bioplex_WMM bioplex3_WMM WMM_only | |
| AMPD2 | GMEB1 | 0.834 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AMPD2 | METTL8 | 0.805 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| AMPD2 | DHRS2 | 0.799 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only | |
| AMPD2 | SDC1 | 0.794 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| USF3 | SDC4 | 0.714 | bioplex3_WMM WMM_only | ||
| USF3 | SDC1 | 0.688 | bioplex3_WMM WMM_only | ||
| AMPD2 | IL7R | 0.482 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AMPD2 | USF3 | 0.405 | bioplex3_WMM WMM_only | ||
| SDC1 | METTL8 | 0.356 | 0.058 | bioplex3_WMM WMM_only |
Related Complexes