hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12841.1
Complex Portal: CPX-23062
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUGCT | Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase) | 5 | UniProt NCBI |
| UGDH | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | 5 | UniProt NCBI |
| EPPIN | Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) | 5 | UniProt NCBI |
| NAMPT | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | 5 | UniProt NCBI |
| GCDH | Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) | 5 | UniProt NCBI |
| SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | 5 | UniProt NCBI |
| FAM118B | Protein FAM118B | 4 | UniProt NCBI |
| UMPS | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] | 5 | UniProt NCBI |
| FAS | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | 5 | UniProt NCBI |
| MAPK15 | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0034688 | 0.000166647713928 | 0.285714285714 | SUGCT GCDH | Reduced peroxisomal glutaryl-CoA oxidase activity |
| HP:0003530 | 0.00166533696614 | 0.285714285714 | SUGCT GCDH | Elevated circulating glutaric acid concentration |
| HP:0003150 | 0.00249743559672 | 0.285714285714 | SUGCT GCDH | Glutaric aciduria |
| HPA:0271142 | 0.00448406864975 | 0.571428571429 | GCDH SUGCT SUCLG2 UGDH | kidney; proximal tubules (cell body)[>=Medium] |
| HPA:0271141 | 0.0115413333869 | 0.571428571429 | GCDH SUGCT SUCLG2 UGDH | kidney; proximal tubules (cell body)[>=Low] |
| HPA:0271143 | 0.0186354583897 | 0.428571428571 | SUGCT SUCLG2 GCDH | kidney; proximal tubules (cell body)[High] |
| HP:0032368 | 0.0315332858987 | 0.285714285714 | SUGCT GCDH | Acidemia |
| HPA:0131302 | 0.0393085024882 | 0.428571428571 | SUGCT SUCLG2 UGDH | colon; enterocytes[>=Medium] |
| HPA:0401302 | 0.0407213919857 | 0.428571428571 | SUGCT SUCLG2 UGDH | rectum; enterocytes[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EPPIN | UMPS | 0.986 | bioplex3_HEK293 bioplex () | ||
| UGDH | FAM118B | 0.979 | 0.044 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UGDH | NAMPT | 0.966 | 0.156 | bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| UMPS | FAM118B | 0.966 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| NAMPT | MAPK15 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| UMPS | GCDH | 0.953 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| UMPS | NAMPT | 0.952 | 0.174 | bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| UGDH | FAS | 0.949 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NAMPT | FAM118B | 0.918 | 0.038 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UMPS | SUCLG2 | 0.91 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| UGDH | UMPS | 0.897 | 0.104 | bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| NAMPT | SUCLG2 | 0.882 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| FAM118B | SUCLG2 | 0.873 | 0.072 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UMPS | FAS | 0.867 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UGDH | SUGCT | 0.852 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| FAS | FAM118B | 0.852 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SUGCT | SUCLG2 | 0.849 | 0.162 | bioplex_WMM bioplex3_WMM WMM_only | |
| GCDH | SUCLG2 | 0.847 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SUGCT | GCDH | 0.807 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| UGDH | SUCLG2 | 0.728 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| GCDH | FAM118B | 0.725 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| SUGCT | UMPS | 0.673 | 0.106 | bioplex_WMM bioplex3_WMM fraction | |
| SUGCT | NAMPT | 0.638 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| NAMPT | GCDH | 0.565 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| UGDH | GCDH | 0.491 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| SUGCT | FAM118B | 0.205 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPPIN | NAMPT | 0.191 | bioplex3_HEK293 bioplex () | ||
| NAMPT | FAS | 0.176 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GCDH | FAS | 0.017 | 0.181 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FAS | SUCLG2 | 0.007 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes