hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12847.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DKKL1 | Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1) | 4 | UniProt NCBI |
| OAT | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | 5 | UniProt NCBI |
| CD300LB | CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) | 5 | UniProt NCBI |
| GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) | 5 | UniProt NCBI |
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | 5 | UniProt NCBI |
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | 5 | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | 5 | UniProt NCBI |
| CINP | Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:258 | 3.92798604902e-08 | 0.375 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:68 | 3.92798604902e-08 | 0.375 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:251 | 3.92798604902e-08 | 0.375 | XRCC2 RAD51D RAD51B | BCDX2 complex |
| CORUM:261 | 9.81744484776e-08 | 0.375 | XRCC2 RAD51D RAD51B | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| GO:0033063 | 2.15253635486e-05 | 0.375 | XRCC2 RAD51D RAD51B | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| CORUM:262 | 2.39226645298e-05 | 0.25 | XRCC2 RAD51D | RAD51L3-XRCC2 complex |
| REAC:R-HSA-9709603 | 4.61108204583e-05 | 0.375 | XRCC2 RAD51D RAD51B | Impaired BRCA2 binding to PALB2 |
| KEGG:03440 | 5.21567264954e-05 | 0.375 | XRCC2 RAD51D RAD51B | Homologous recombination |
| REAC:R-HSA-9701193 | 5.23852014749e-05 | 0.375 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9704331 | 5.23852014749e-05 | 0.375 | XRCC2 RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 5.23852014749e-05 | 0.375 | XRCC2 RAD51D RAD51B | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701192 | 5.23852014749e-05 | 0.375 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-5693554 | 6.65860913492e-05 | 0.375 | XRCC2 RAD51D RAD51B | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| CORUM:2228 | 7.17483486175e-05 | 0.25 | XRCC2 RAD51D | BLM-RAD51L3-XRCC2 complex |
| GO:0033061 | 0.00010757157937 | 0.375 | XRCC2 RAD51D RAD51B | DNA recombinase mediator complex |
| REAC:R-HSA-5693568 | 0.000124011659906 | 0.375 | XRCC2 RAD51D RAD51B | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.000135977842763 | 0.375 | XRCC2 RAD51D RAD51B | Resolution of D-Loop Structures |
| REAC:R-HSA-5693616 | 0.000207404030729 | 0.375 | XRCC2 RAD51D RAD51B | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9675136 | 0.000224162952172 | 0.375 | XRCC2 RAD51D RAD51B | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 0.000224162952172 | 0.375 | XRCC2 RAD51D RAD51B | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5693579 | 0.000260330782854 | 0.375 | XRCC2 RAD51D RAD51B | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 0.000417047988419 | 0.375 | XRCC2 RAD51D RAD51B | Diseases of DNA repair |
| REAC:R-HSA-5685942 | 0.00103131007969 | 0.375 | XRCC2 RAD51D RAD51B | HDR through Homologous Recombination (HRR) |
| GO:0000400 | 0.00364711882004 | 0.375 | XRCC2 RAD51D RAD51B | four-way junction DNA binding |
| REAC:R-HSA-5693567 | 0.00672088844441 | 0.375 | XRCC2 RAD51D RAD51B | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00775010993696 | 0.375 | XRCC2 RAD51D RAD51B | Homology Directed Repair |
| REAC:R-HSA-5693532 | 0.0141950226766 | 0.375 | XRCC2 RAD51D RAD51B | DNA Double-Strand Break Repair |
| GO:0000217 | 0.0291427400779 | 0.375 | XRCC2 RAD51D RAD51B | DNA secondary structure binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAD51D | XRCC2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | DKKL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAD51B | XRCC2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GADD45A | DKKL1 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAD51D | RAD51B | 0.997 | 0.186 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CINP | DKKL1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAD51D | DKKL1 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XRCC2 | DKKL1 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RAD51B | CD300LB | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OAT | DKKL1 | 0.909 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GADD45A | RAD51B | 0.658 | bioplex_WMM bioplex3_WMM WMM_only | |
| CINP | RAD51B | 0.633 | 0.216 | bioplex3_WMM WMM_only |
| GADD45A | CINP | 0.388 | bioplex3_WMM WMM_only | |
| GADD45A | XRCC2 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| GADD45A | RAD51D | 0.258 | bioplex_WMM bioplex3_WMM WMM_only | |
| OAT | RAD51D | 0.075 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| OAT | RAD51B | 0.064 | 0.072 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CINP | RAD51D | 0.054 | 0.102 | bioplex3_WMM WMM_only |
| OAT | XRCC2 | 0.047 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CINP | XRCC2 | 0.041 | bioplex3_WMM WMM_only | |
| CINP | OAT | 0.018 | 0.058 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| GADD45A | OAT | 0.018 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OAT | CD300LB | 0.003 | bioplex3_HEK293 bioplex3_HCT116 WMM_only |
Related Complexes