hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12848.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) | 5 | UniProt NCBI |
| GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) | 5 | UniProt NCBI |
| GABRA6 | Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) | 5 | UniProt NCBI |
| GLRA3 | Glycine receptor subunit alpha-3 | 5 | UniProt NCBI |
| GCNT3 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0099095 | 6.50952358374e-08 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | ligand-gated monoatomic anion channel activity |
| KEGG:05033 | 1.88473588104e-06 | 0.6 | GABRB3 GABRB2 GABRA6 | Nicotine addiction |
| WP:WP4159 | 2.43879140385e-06 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA receptor signaling |
| WP:WP4829 | 4.40057593888e-06 | 0.6 | GABRB3 GABRB2 GABRA6 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04080 | 6.23815847072e-06 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | Neuroactive ligand-receptor interaction |
| GO:1902476 | 6.87695434453e-06 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | chloride transmembrane transport |
| REAC:R-HSA-112314 | 1.05854142603e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0022824 | 1.19998568947e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | transmitter-gated monoatomic ion channel activity |
| GO:0022835 | 1.19998568947e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | transmitter-gated channel activity |
| GO:0098656 | 1.95582475037e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | monoatomic anion transmembrane transport |
| GO:0005254 | 1.95582475037e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | chloride channel activity |
| GO:0005230 | 1.95582475037e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | extracellular ligand-gated monoatomic ion channel activity |
| GO:0098661 | 2.14197622369e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | inorganic anion transmembrane transport |
| REAC:R-HSA-112315 | 2.9019356916e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | Transmission across Chemical Synapses |
| GO:0030594 | 3.27930250282e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | neurotransmitter receptor activity |
| REAC:R-HSA-977443 | 3.31378787787e-05 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA receptor activation |
| GO:0006821 | 4.14930734417e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | chloride transport |
| KEGG:04727 | 4.44119474406e-05 | 0.6 | GABRB3 GABRB2 GABRA6 | GABAergic synapse |
| KEGG:05032 | 4.64569454207e-05 | 0.6 | GABRB3 GABRB2 GABRA6 | Morphine addiction |
| GO:0005253 | 4.81842507515e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | monoatomic anion channel activity |
| GO:0022851 | 5.37995977657e-05 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA-gated chloride ion channel activity |
| GO:0015108 | 9.44983107329e-05 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | chloride transmembrane transporter activity |
| GO:0004890 | 0.000115261178119 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA-A receptor activity |
| GO:1902711 | 0.000115261178119 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA-A receptor complex |
| REAC:R-HSA-112316 | 0.000135335223169 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | Neuronal System |
| GO:0006820 | 0.000150799788408 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | monoatomic anion transport |
| GO:0015698 | 0.000159286795625 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | inorganic anion transport |
| GO:1902710 | 0.000211268761872 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA receptor complex |
| GO:0008509 | 0.000217964056115 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | monoatomic anion transmembrane transporter activity |
| KEGG:04723 | 0.0002524957978 | 0.6 | GABRB3 GABRB2 GABRA6 | Retrograde endocannabinoid signaling |
| GO:0015103 | 0.000265205672168 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | inorganic anion transmembrane transporter activity |
| GO:0016917 | 0.000274621184043 | 0.6 | GABRB3 GABRB2 GABRA6 | GABA receptor activity |
| GO:0007214 | 0.000349481973524 | 0.6 | GABRB3 GABRB2 GABRA6 | gamma-aminobutyric acid signaling pathway |
| GO:0022834 | 0.000625424261446 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | ligand-gated channel activity |
| GO:0015276 | 0.000625424261446 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | ligand-gated monoatomic ion channel activity |
| GO:0051932 | 0.00169879277018 | 0.6 | GABRB3 GABRB2 GABRA6 | synaptic transmission, GABAergic |
| GO:0022836 | 0.00526877477961 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | gated channel activity |
| REAC:R-HSA-1236394 | 0.0136499247655 | 0.4 | GABRB3 GABRB2 | Signaling by ERBB4 |
| KEGG:04726 | 0.0156689936932 | 0.4 | GABRB3 GABRB2 | Serotonergic synapse |
| GO:0005216 | 0.0252691756905 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | monoatomic ion channel activity |
| GO:0015267 | 0.0384230454852 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | channel activity |
| GO:0022803 | 0.0389526852651 | 0.8 | GABRB3 GLRA3 GABRB2 GABRA6 | passive transmembrane transporter activity |
| GO:0071420 | 0.0468008499735 | 0.4 | GABRB3 GABRB2 | cellular response to histamine |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GABRB2 | GABRB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GABRB3 | GABRA6 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GLRA3 | GCNT3 | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GLRA3 | GABRB3 | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GCNT3 | GABRB3 | 0.25 | bioplex3_WMM WMM_only |
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