hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12849.1
Complex Portal: CPX-22863
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | 5 | UniProt NCBI |
| PIKFYVE | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | 5 | UniProt NCBI |
| FIG4 | Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6186 | 5.12628525639e-06 | 1.0 | PIKFYVE FIG4 | ArPIKfyve-Sac3-Sph1 complex |
| REAC:R-HSA-1660517 | 9.39818963671e-05 | 1.0 | PIKFYVE FIG4 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1660516 | 0.000179419983974 | 1.0 | PIKFYVE FIG4 | Synthesis of PIPs at the early endosome membrane |
| REAC:R-HSA-1660514 | 0.000205051410255 | 1.0 | PIKFYVE FIG4 | Synthesis of PIPs at the Golgi membrane |
| KEGG:00562 | 0.000338144964505 | 1.0 | PIKFYVE FIG4 | Inositol phosphate metabolism |
| WP:WP5411 | 0.00036647347272 | 1.0 | PIKFYVE FIG4 | Phosphatidyl inositol phosphate pathway |
| REAC:R-HSA-1483255 | 0.00436759503844 | 1.0 | PIKFYVE FIG4 | PI Metabolism |
| GO:0043813 | 0.00468200720083 | 1.0 | PIKFYVE FIG4 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| REAC:R-HSA-1483257 | 0.0263149309828 | 1.0 | PIKFYVE FIG4 | Phospholipid metabolism |
| GO:0034595 | 0.0309012475255 | 1.0 | PIKFYVE FIG4 | phosphatidylinositol phosphate 5-phosphatase activity |
| GO:0106018 | 0.0426062655276 | 1.0 | PIKFYVE FIG4 | phosphatidylinositol-3,5-bisphosphate phosphatase activity |
| HP:0007962 | 0.0499436884913 | 0.5 | PIKFYVE | Speckled corneal dystrophy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FIG4 | PIKFYVE | 0.999 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FIG4 | ANK1 | 0.878 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIKFYVE | ANK1 | 0.847 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| ANK1 | huMAP3_09210.1 huMAP3_09558.1 huMAP3_10688.1 huMAP3_12849.1 huMAP3_13923.1 huMAP3_14302.1 |
| PIKFYVE | huMAP3_03898.1 huMAP3_07053.1 huMAP3_12849.1 huMAP3_14302.1 |
| FIG4 | huMAP3_03898.1 huMAP3_05707.1 huMAP3_12849.1 huMAP3_14302.1 |