hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12853.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRKCA | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | 5 | UniProt NCBI |
| PRKCB | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | 5 | UniProt NCBI |
| PRKCG | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-114516 | 1.70876175213e-05 | 1.0 | PRKCB PRKCG | Disinhibition of SNARE formation |
| KEGG:04960 | 7.07178170959e-05 | 1.0 | PRKCB PRKCG | Aldosterone-regulated sodium reabsorption |
| KEGG:05143 | 7.55949079301e-05 | 1.0 | PRKCB PRKCG | African trypanosomiasis |
| REAC:R-HSA-416993 | 0.000112778275641 | 1.0 | PRKCB PRKCG | Trafficking of GluR2-containing AMPA receptors |
| KEGG:04929 | 0.000160943997529 | 1.0 | PRKCB PRKCG | GnRH secretion |
| KEGG:04961 | 0.000175737839726 | 1.0 | PRKCB PRKCG | Endocrine and other factor-regulated calcium reabsorption |
| REAC:R-HSA-5099900 | 0.000179419983974 | 1.0 | PRKCB PRKCG | WNT5A-dependent internalization of FZD4 |
| KEGG:04730 | 0.000183378615366 | 1.0 | PRKCB PRKCG | Long-term depression |
| KEGG:04370 | 0.000207276360454 | 1.0 | PRKCB PRKCG | VEGF signaling pathway |
| WP:WP4871 | 0.000211115961056 | 1.0 | PRKCB PRKCG | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP2636 | 0.000211115961056 | 1.0 | PRKCB PRKCG | Common pathways underlying drug addiction |
| KEGG:04971 | 0.000224021038984 | 1.0 | PRKCB PRKCG | Gastric acid secretion |
| WP:WP5283 | 0.00022473634564 | 1.0 | PRKCB PRKCG | Chronic hyperglycemia impairment of neuron function |
| KEGG:04720 | 0.000232637232791 | 1.0 | PRKCB PRKCG | Long-term potentiation |
| KEGG:05031 | 0.00025946123238 | 1.0 | PRKCB PRKCG | Amphetamine addiction |
| KEGG:04918 | 0.000287748359218 | 1.0 | PRKCB PRKCG | Thyroid hormone synthesis |
| KEGG:04970 | 0.000327740504058 | 1.0 | PRKCB PRKCG | Salivary secretion |
| KEGG:04911 | 0.000338144964505 | 1.0 | PRKCB PRKCG | Insulin secretion |
| KEGG:04727 | 0.000359441594481 | 1.0 | PRKCB PRKCG | GABAergic synapse |
| KEGG:05223 | 0.00037033376401 | 1.0 | PRKCB PRKCG | Non-small cell lung cancer |
| KEGG:05032 | 0.00037033376401 | 1.0 | PRKCB PRKCG | Morphine addiction |
| KEGG:05214 | 0.00037033376401 | 1.0 | PRKCB PRKCG | Glioma |
| KEGG:04750 | 0.000381388503235 | 1.0 | PRKCB PRKCG | Inflammatory mediator regulation of TRP channels |
| KEGG:04540 | 0.000403985690766 | 1.0 | PRKCB PRKCG | Gap junction |
| KEGG:04972 | 0.000415528139074 | 1.0 | PRKCB PRKCG | Pancreatic secretion |
| WP:WP363 | 0.000421380648075 | 1.0 | PRKCB PRKCG | Wnt signaling pathway |
| KEGG:04713 | 0.000427233157076 | 1.0 | PRKCB PRKCG | Circadian entrainment |
| KEGG:01521 | 0.000439100744773 | 1.0 | PRKCB PRKCG | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04925 | 0.000439100744773 | 1.0 | PRKCB PRKCG | Aldosterone synthesis and secretion |
| KEGG:04012 | 0.000463323629249 | 1.0 | PRKCB PRKCG | ErbB signaling pathway |
| REAC:R-HSA-399721 | 0.000512628525639 | 1.0 | PRKCB PRKCG | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-399719 | 0.000512628525639 | 1.0 | PRKCB PRKCG | Trafficking of AMPA receptors |
| KEGG:04724 | 0.000526725810094 | 1.0 | PRKCB PRKCG | Glutamatergic synapse |
| KEGG:04916 | 0.000553224670293 | 1.0 | PRKCB PRKCG | Melanogenesis |
| KEGG:04928 | 0.000553224670293 | 1.0 | PRKCB PRKCG | Parathyroid hormone synthesis, secretion and action |
| KEGG:05231 | 0.000553224670293 | 1.0 | PRKCB PRKCG | Choline metabolism in cancer |
| KEGG:04726 | 0.000566717954934 | 1.0 | PRKCB PRKCG | Serotonergic synapse |
| KEGG:04070 | 0.00058037380927 | 1.0 | PRKCB PRKCG | Phosphatidylinositol signaling system |
| KEGG:05146 | 0.0005941922333 | 1.0 | PRKCB PRKCG | Amoebiasis |
| KEGG:04670 | 0.0005941922333 | 1.0 | PRKCB PRKCG | Leukocyte transendothelial migration |
| KEGG:04725 | 0.000636622923558 | 1.0 | PRKCB PRKCG | Cholinergic synapse |
| KEGG:04666 | 0.000651091626366 | 1.0 | PRKCB PRKCG | Fc gamma R-mediated phagocytosis |
| KEGG:04270 | 0.000741317806799 | 1.0 | PRKCB PRKCG | Vascular smooth muscle contraction |
| KEGG:04066 | 0.00078862558789 | 1.0 | PRKCB PRKCG | HIF-1 signaling pathway |
| KEGG:04935 | 0.000804719987643 | 1.0 | PRKCB PRKCG | Growth hormone synthesis, secretion and action |
| WP:WP4341 | 0.000831269096657 | 1.0 | PRKCB PRKCG | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04071 | 0.000853978605069 | 1.0 | PRKCB PRKCG | Sphingolipid signaling pathway |
| KEGG:04919 | 0.000887630531825 | 1.0 | PRKCB PRKCG | Thyroid hormone signaling pathway |
| WP:WP4255 | 0.000941083447368 | 1.0 | PRKCB PRKCG | Non small cell lung cancer |
| KEGG:04650 | 0.00095688522167 | 1.0 | PRKCB PRKCG | Natural killer cell mediated cytotoxicity |
| KEGG:04728 | 0.00095688522167 | 1.0 | PRKCB PRKCG | Dopaminergic synapse |
| REAC:R-HSA-418597 | 0.00101671324252 | 1.0 | PRKCB PRKCG | G alpha (z) signalling events |
| KEGG:04921 | 0.00112221860095 | 1.0 | PRKCB PRKCG | Oxytocin signaling pathway |
| KEGG:04723 | 0.0011414018249 | 1.0 | PRKCB PRKCG | Retrograde endocannabinoid signaling |
| WP:WP2261 | 0.00124541391542 | 1.0 | PRKCB PRKCG | Glioblastoma signaling pathways |
| KEGG:05017 | 0.00125991513217 | 1.0 | PRKCB PRKCG | Spinocerebellar ataxia |
| WP:WP35 | 0.00127818796583 | 1.0 | PRKCB PRKCG | G protein signaling pathways |
| WP:WP4806 | 0.00131138765325 | 1.0 | PRKCB PRKCG | EGFR tyrosine kinase inhibitor resistance |
| WP:WP673 | 0.00137906393915 | 1.0 | PRKCB PRKCG | ErbB signaling pathway |
| WP:WP4540 | 0.00141354053763 | 1.0 | PRKCB PRKCG | Hippo signaling regulation pathways |
| KEGG:05206 | 0.00176843313648 | 1.0 | PRKCB PRKCG | MicroRNAs in cancer |
| KEGG:04150 | 0.00176843313648 | 1.0 | PRKCB PRKCG | mTOR signaling pathway |
| KEGG:05161 | 0.00176843313648 | 1.0 | PRKCB PRKCG | Hepatitis B |
| KEGG:04613 | 0.00179249345126 | 1.0 | PRKCB PRKCG | Neutrophil extracellular trap formation |
| KEGG:04310 | 0.00181671633574 | 1.0 | PRKCB PRKCG | Wnt signaling pathway |
| WP:WP399 | 0.0018604594068 | 1.0 | PRKCB PRKCG | Wnt signaling pathway and pluripotency |
| KEGG:05225 | 0.00204203793228 | 1.0 | PRKCB PRKCG | Hepatocellular carcinoma |
| KEGG:05207 | 0.00214640767613 | 1.0 | PRKCB PRKCG | Chemical carcinogenesis - receptor activation |
| WP:WP428 | 0.0021494669422 | 1.0 | PRKCB PRKCG | Wnt signaling |
| WP:WP4787 | 0.00219245628104 | 1.0 | PRKCB PRKCG | Osteoblast differentiation and related diseases |
| KEGG:04015 | 0.00222639196581 | 1.0 | PRKCB PRKCG | Rap1 signaling pathway |
| KEGG:04020 | 0.00239074992693 | 1.0 | PRKCB PRKCG | Calcium signaling pathway |
| KEGG:04510 | 0.00241871191437 | 1.0 | PRKCB PRKCG | Focal adhesion |
| WP:WP5083 | 0.00259851399646 | 1.0 | PRKCB PRKCG | Neuroinflammation and glutamatergic signaling |
| WP:WP536 | 0.00264575970549 | 1.0 | PRKCB PRKCG | Calcium regulation in cardiac cells |
| KEGG:05415 | 0.00267768543767 | 1.0 | PRKCB PRKCG | Diabetic cardiomyopathy |
| KEGG:05205 | 0.00267768543767 | 1.0 | PRKCB PRKCG | Proteoglycans in cancer |
| KEGG:04014 | 0.00273702337615 | 1.0 | PRKCB PRKCG | Ras signaling pathway |
| KEGG:05163 | 0.00298087791786 | 1.0 | PRKCB PRKCG | Human cytomegalovirus infection |
| KEGG:05170 | 0.0030120912992 | 1.0 | PRKCB PRKCG | Human immunodeficiency virus 1 infection |
| KEGG:05171 | 0.0033003273675 | 1.0 | PRKCB PRKCG | Coronavirus disease - COVID-19 |
| WP:WP289 | 0.00362429921046 | 1.0 | PRKCB PRKCG | Myometrial relaxation and contraction pathways |
| WP:WP4666 | 0.00396523446209 | 1.0 | PRKCB PRKCG | Hepatitis B infection |
| WP:WP4223 | 0.00456751084292 | 1.0 | PRKCB PRKCG | Ras signaling |
| KEGG:04010 | 0.0047800367266 | 1.0 | PRKCB PRKCG | MAPK signaling pathway |
| WP:WP306 | 0.00633262755764 | 1.0 | PRKCB PRKCG | Focal adhesion |
| REAC:R-HSA-4086400 | 0.00699737937497 | 1.0 | PRKCB PRKCG | PCP/CE pathway |
| REAC:R-HSA-76005 | 0.010244026704 | 1.0 | PRKCB PRKCG | Response to elevated platelet cytosolic Ca2+ |
| KEGG:05022 | 0.0138982457502 | 1.0 | PRKCB PRKCG | Pathways of neurodegeneration - multiple diseases |
| WP:WP5420 | 0.0144418640295 | 1.0 | PRKCB PRKCG | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-3858494 | 0.0156864328845 | 1.0 | PRKCB PRKCG | Beta-catenin independent WNT signaling |
| KEGG:05200 | 0.0161326036311 | 1.0 | PRKCB PRKCG | Pathways in cancer |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | PRKCB PRKCG | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | PRKCB PRKCG | Transmission across Chemical Synapses |
| REAC:R-HSA-76002 | 0.0400465404229 | 1.0 | PRKCB PRKCG | Platelet activation, signaling and aggregation |
| GO:0004697 | 0.0426062655276 | 1.0 | PRKCB PRKCG | diacylglycerol-dependent serine/threonine kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRKCA | PRKCG | 0.983 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PRKCA | PRKCB | 0.97 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PRKCB | PRKCG | 0.557 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PRKCA | huMAP3_01710.1 huMAP3_06641.1 huMAP3_07229.1 huMAP3_12853.1 |
| PRKCB | huMAP3_01710.1 huMAP3_12394.1 huMAP3_12853.1 huMAP3_15268.1 |
| PRKCG | huMAP3_01710.1 huMAP3_06641.1 huMAP3_07229.1 huMAP3_12853.1 |