hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12859.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ASCC2 | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | 5 | UniProt NCBI |
| ALKBH3 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) | 5 | UniProt NCBI |
| ASCC1 | Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112126 | 1.86640856459e-09 | 1.0 | ASCC1 ASCC2 ALKBH3 | ALKBH3 mediated reversal of alkylation damage |
| REAC:R-HSA-73942 | 1.63310749402e-08 | 1.0 | ASCC1 ASCC2 ALKBH3 | DNA Damage Reversal |
| REAC:R-HSA-73943 | 1.63310749402e-08 | 1.0 | ASCC1 ASCC2 ALKBH3 | Reversal of alkylation damage by DNA dioxygenases |
| GO:0006307 | 5.38272230028e-06 | 1.0 | ASCC1 ASCC2 ALKBH3 | DNA dealkylation involved in DNA repair |
| CORUM:1377 | 2.05032700758e-05 | 0.666666666667 | ASCC1 ASCC2 | hASC-1 complex |
| GO:0035510 | 0.000221076094476 | 1.0 | ASCC1 ASCC2 ALKBH3 | DNA dealkylation |
| REAC:R-HSA-73894 | 0.00220643087689 | 1.0 | ASCC1 ASCC2 ALKBH3 | DNA Repair |
| GO:0006304 | 0.0028124724019 | 1.0 | ASCC1 ASCC2 ALKBH3 | DNA modification |
| WP:WP4931 | 0.0165527833611 | 0.333333333333 | ALKBH3 | Direct reversal repair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ASCC2 | ASCC1 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ALKBH3 | ASCC1 | 0.992 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ASCC2 | ALKBH3 | 0.99 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| ASCC2 | huMAP3_00443.1 huMAP3_12859.1 huMAP3_13900.1 |
| ALKBH3 | huMAP3_00443.1 huMAP3_12859.1 huMAP3_13900.1 |
| ASCC1 | huMAP3_00443.1 huMAP3_12859.1 huMAP3_13683.1 huMAP3_13900.1 |