hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12869.1

Complex Portal: CPX-12019

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SACM1L	Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)	5	UniProt NCBI
COPB2	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)	5	UniProt NCBI
HTR3D	5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D)	5	UniProt NCBI
COPG2	Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)	5	UniProt NCBI
ERGIC3	Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)	5	UniProt NCBI
COPG1	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	5	UniProt NCBI
ARCN1	Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)	5	UniProt NCBI
COPZ2	Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP)	4	UniProt NCBI
NSG2	Neuronal vesicle trafficking-associated protein 2 (Neuron-specific protein family member 2) (Protein p19) (Hmp19)	5	UniProt NCBI
COPZ1	Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)	5	UniProt NCBI
BCAP29	B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29)	4	UniProt NCBI
KCNJ10	ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1) (Inward rectifier K(+) channel Kir1.2) (Potassium channel, inwardly rectifying subfamily J member 10)	5	UniProt NCBI
COPA	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	5	UniProt NCBI
COPB1	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	5	UniProt NCBI
KCNJ12	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)	5	UniProt NCBI
COPE	Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030126	4.88198201019e-21	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	COPI vesicle coat
GO:0030663	1.65701101415e-19	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	COPI-coated vesicle membrane
GO:0030137	1.14336242564e-18	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	COPI-coated vesicle
GO:0030660	5.96762290139e-15	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Golgi-associated vesicle membrane
REAC:R-HSA-6811434	3.70994917491e-14	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	COPI-dependent Golgi-to-ER retrograde traffic
REAC:R-HSA-6807878	4.99446703016e-14	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	COPI-mediated anterograde transport
GO:0030120	6.02706226743e-14	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	vesicle coat
GO:0006891	1.2983073647e-13	0.5	COPB2 COPZ1 COPB1 COPE COPZ2 COPG1 COPG2 COPA	intra-Golgi vesicle-mediated transport
GO:0005798	3.77700588793e-13	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Golgi-associated vesicle
REAC:R-HSA-8856688	6.26105807473e-13	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Golgi-to-ER retrograde transport
REAC:R-HSA-199977	2.0115703473e-12	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	ER to Golgi Anterograde Transport
GO:0030117	3.39187227451e-12	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	membrane coat
GO:0048475	3.39187227451e-12	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	coated membrane
REAC:R-HSA-948021	1.09374956226e-11	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Transport to the Golgi and subsequent modification
GO:0048193	1.40564919205e-11	0.6875	ERGIC3 COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPZ2 BCAP29 COPG2 COPG1	Golgi vesicle transport
REAC:R-HSA-6811442	3.12905425869e-11	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0006888	5.83351726948e-11	0.5625	ERGIC3 COPB2 COPB1 BCAP29 COPA COPE COPG1 ARCN1 COPG2	endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0030135	2.06636919947e-10	0.625	ERGIC3 COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPZ2 COPG2 COPG1	coated vesicle
GO:0030662	4.43306716224e-10	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	coated vesicle membrane
REAC:R-HSA-446203	1.00185184032e-09	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Asparagine N-linked glycosylation
GO:0006890	1.97822432741e-09	0.4375	ERGIC3 COPB2 ARCN1 COPZ1 COPA COPZ2 COPG2	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0030133	6.01559621652e-08	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	transport vesicle
GO:0000139	8.05788578479e-08	0.625	COPB2 COPB1 ARCN1 SACM1L COPZ1 COPA COPE COPZ2 COPG1 COPG2	Golgi membrane
GO:0031984	3.35250407827e-07	0.75	COPA COPB2 COPB1 ARCN1 SACM1L COPZ1 NSG2 COPE COPZ2 COPG1 BCAP29 COPG2	organelle subcompartment
GO:0005789	5.17705384677e-07	0.6875	COPB2 COPB1 ARCN1 SACM1L COPZ1 COPA COPE COPZ2 COPG1 BCAP29 COPG2	endoplasmic reticulum membrane
REAC:R-HSA-199991	5.38047451479e-07	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Membrane Trafficking
GO:0098827	6.12656583306e-07	0.6875	COPB2 COPB1 ARCN1 SACM1L COPZ1 COPA COPE COPZ2 COPG1 BCAP29 COPG2	endoplasmic reticulum subcompartment
GO:0042175	6.70843343203e-07	0.6875	COPB2 COPB1 ARCN1 SACM1L COPZ1 COPA COPE COPZ2 COPG1 BCAP29 COPG2	nuclear outer membrane-endoplasmic reticulum membrane network
REAC:R-HSA-5653656	8.679237088e-07	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Vesicle-mediated transport
GO:0046907	1.74278866894e-06	0.75	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 BCAP29 COPG2 COPG1	intracellular transport
GO:0016192	2.09400326655e-06	0.75	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 BCAP29 COPG2 COPG1	vesicle-mediated transport
GO:0006810	9.29094466594e-06	0.9375	ERGIC3 COPA COPB2 NSG2 ARCN1 COPB1 COPZ1 HTR3D COPE COPZ2 COPG1 BCAP29 KCNJ10 KCNJ12 COPG2	transport
GO:0005783	3.10088060072e-05	0.75	ERGIC3 COPB2 COPB1 ARCN1 SACM1L COPZ1 COPA COPE COPZ2 COPG2 BCAP29 COPG1	endoplasmic reticulum
GO:0051649	3.23430599434e-05	0.75	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 BCAP29 COPG2 COPG1	establishment of localization in cell
GO:0051234	3.57851426044e-05	0.9375	ERGIC3 COPA COPB2 NSG2 ARCN1 COPB1 COPZ1 HTR3D COPE COPZ2 COPG1 BCAP29 KCNJ10 KCNJ12 COPG2	establishment of localization
GO:0030659	3.65738080395e-05	0.625	COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPG1 COPG2 COPZ2	cytoplasmic vesicle membrane
GO:0012506	4.26964461622e-05	0.625	COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPG1 COPG2 COPZ2	vesicle membrane
GO:0005794	8.40554037142e-05	0.6875	COPA COPB2 COPB1 ARCN1 SACM1L COPZ1 NSG2 COPE COPZ2 COPG1 COPG2	Golgi apparatus
GO:0098796	0.000271849721885	0.625	COPA COPB2 COPB1 ARCN1 COPZ1 HTR3D COPE COPZ2 COPG2 COPG1	membrane protein complex
GO:0051179	0.000343461623747	0.9375	ERGIC3 COPA COPB2 NSG2 ARCN1 COPB1 COPZ1 HTR3D COPE COPZ2 COPG1 BCAP29 KCNJ10 KCNJ12 COPG2	localization
REAC:R-HSA-597592	0.000404992011324	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Post-translational protein modification
GO:0098588	0.00117139000066	0.6875	COPA COPB2 COPB1 ARCN1 SACM1L COPZ1 NSG2 COPE COPZ2 COPG1 COPG2	bounding membrane of organelle
GO:0031410	0.00492624013212	0.6875	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 COPG2 COPG1	cytoplasmic vesicle
GO:0097708	0.00502022754315	0.6875	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 COPG2 COPG1	intracellular vesicle
REAC:R-HSA-392499	0.00617373322543	0.5625	COPB2 COPB1 ARCN1 COPZ1 COPA COPE COPG1 COPG2 COPZ2	Metabolism of proteins
GO:0016020	0.0147946893739	1.0	ERGIC3 COPA COPB2 NSG2 ARCN1 COPB1 SACM1L COPZ1 HTR3D COPE COPZ2 COPG2 BCAP29 KCNJ10 KCNJ12 COPG1	membrane
GO:0051641	0.0165720233923	0.75	ERGIC3 COPA COPB2 COPB1 ARCN1 COPZ1 NSG2 COPE COPZ2 BCAP29 COPG2 COPG1	cellular localization
GO:0015031	0.0242740751098	0.5	ERGIC3 COPB2 ARCN1 COPZ1 COPA COPZ2 COPG2 COPG1	protein transport
GO:0031090	0.0253054596229	0.75	COPA COPB2 COPB1 ARCN1 SACM1L COPZ1 NSG2 COPE COPZ2 COPG1 BCAP29 COPG2	organelle membrane

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
COPB2	COPE	1.0	0.964
COPA	COPE	1.0	0.924
COPB1	COPE	1.0	0.962
COPB2	COPA	1.0	0.964	structurally_consistent (dimer)
COPG1	COPE	1.0	0.91	structurally_consistent (dimer)
COPB2	COPG1	1.0	0.962
COPG1	ARCN1	1.0	0.85	structurally_consistent (P53618)
ARCN1	COPB1	1.0	0.986	structurally_consistent (dimer)
COPG1	COPB1	1.0	0.99	structurally_consistent (dimer)
ARCN1	COPA	1.0	0.816
COPB2	ARCN1	1.0	0.972
COPA	COPB1	1.0	0.986	structurally_consistent (P35606) structurally_consistent (dimer)
COPG2	COPE	1.0	0.428
COPB2	COPB1	1.0	0.974	structurally_consistent (dimer)
COPG1	COPA	1.0	0.952
COPG2	COPG1	0.999	0.476	structurally_consistent (dimer)
ARCN1	COPE	0.999	0.88	structurally_consistent (dimer)
COPG2	COPB1	0.999	0.864	structurally_consistent (dimer)
COPG1	COPZ1	0.999	0.724	structurally_consistent (dimer)
SACM1L	COPG1	0.999	0.14
SACM1L	COPE	0.999	0.096
SACM1L	COPZ1	0.999	0.12
COPG2	COPA	0.999	0.76	structurally_consistent (P53618)
COPG2	ARCN1	0.998	0.578
COPG2	COPZ1	0.998	0.464	structurally_consistent (P53618)
COPB2	COPG2	0.998	0.812
ARCN1	COPZ1	0.997	0.842
COPZ1	COPA	0.997	0.798
SACM1L	COPG2	0.997	0.2
COPB2	COPZ1	0.996	0.916666666667
COPZ1	COPB1	0.996	0.912	structurally_consistent (dimer)
KCNJ12	KCNJ10	0.996		structurally_consistent (dimer)
COPZ1	COPE	0.996	0.882
COPG1	COPZ2	0.991	0.174	structurally_consistent (dimer)
SACM1L	COPA	0.988	0.302
COPG2	KCNJ10	0.988		structurally_consistent (dimer)
COPZ2	COPB1	0.987	0.332
ERGIC3	NSG2	0.987
COPZ2	COPA	0.984	0.332
COPB2	COPZ2	0.984	0.37
COPZ2	COPE	0.983	0.264	structurally_consistent (dimer)
ARCN1	COPZ2	0.98	0.316
ERGIC3	COPG1	0.976	0.066	structurally_consistent (O14579)
COPG1	KCNJ10	0.974		structurally_consistent (Q9UBF2) structurally_consistent (dimer)
SACM1L	COPB2	0.968	0.456
ERGIC3	COPG2	0.956	0.068
SACM1L	ARCN1	0.93	0.126
COPB1	KCNJ10	0.923
COPA	BCAP29	0.921	0.076
COPG2	BCAP29	0.904	0.102
COPA	KCNJ10	0.878
ERGIC3	COPB2	0.875	0.124
ERGIC3	COPE	0.866	0.108	structurally_consistent (dimer)
COPG2	HTR3D	0.856
ARCN1	KCNJ10	0.828
SACM1L	COPB1	0.811	0.188
COPB2	KCNJ10	0.802
COPE	KCNJ10	0.594
ERGIC3	COPA	0.591	0.122
ERGIC3	ARCN1	0.578	0.064	structurally_consistent (O14579)
COPZ1	KCNJ10	0.555		mutually_exclusive (Q9Y678)
KCNJ12	COPG2	0.486
COPB2	BCAP29	0.439	0.064
COPG1	BCAP29	0.439	0.032
ERGIC3	SACM1L	0.349	0.168
COPB1	BCAP29	0.312	0.036
ERGIC3	COPB1	0.295	0.09
ERGIC3	COPZ1	0.277	0.054
COPZ1	BCAP29	0.248	0.042
ARCN1	BCAP29	0.221	0.056
COPA	HTR3D	0.21
COPB2	HTR3D	0.209
COPE	BCAP29	0.168	0.044
KCNJ12	SACM1L	0.137
COPG2	COPZ2	0.127	0.142
KCNJ12	COPB2	0.096
KCNJ12	COPA	0.096
KCNJ12	COPG1	0.096		mutually_exclusive (P78508)
ARCN1	HTR3D	0.087
KCNJ12	COPB1	0.078
SACM1L	BCAP29	0.07	0.114
KCNJ12	COPE	0.062
COPE	HTR3D	0.058
COPG1	HTR3D	0.05
KCNJ12	ARCN1	0.048
COPB1	HTR3D	0.046
ERGIC3	BCAP29	0.036	0.122
KCNJ12	COPZ1	0.035
SACM1L	KCNJ10	0.026
ERGIC3	KCNJ12	0.022
NSG2	ARCN1	0.012

Related Complexes

Genename	Complexes
SACM1L	huMAP3_04405.1 huMAP3_09332.1 huMAP3_12869.1
COPB2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
HTR3D	huMAP3_12869.1 huMAP3_13915.1
COPG2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
ERGIC3	huMAP3_01819.1 huMAP3_06842.1 huMAP3_07941.1 huMAP3_09255.1 huMAP3_12869.1
COPG1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
ARCN1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
COPZ2	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
NSG2	huMAP3_01819.1 huMAP3_02081.1 huMAP3_06842.1 huMAP3_07941.1 huMAP3_09090.1 huMAP3_11238.1 huMAP3_12869.1 huMAP3_14687.1
COPZ1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
BCAP29	huMAP3_12869.1
KCNJ10	huMAP3_08801.1 huMAP3_10156.1 huMAP3_11357.1 huMAP3_11837.1 huMAP3_12869.1
COPA	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
COPB1	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1
KCNJ12	huMAP3_02988.1 huMAP3_03451.1 huMAP3_08801.1 huMAP3_11357.1 huMAP3_11358.1 huMAP3_12869.1 huMAP3_13438.1 huMAP3_14543.1 huMAP3_15147.1
COPE	huMAP3_04405.1 huMAP3_09332.1 huMAP3_11357.1 huMAP3_12869.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12869.1

Complex Portal: CPX-12019