hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12870.1
Complex Portal: CPX-20168
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PICK1 | PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) | 5 | UniProt NCBI |
| ICA1L | Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein) | 5 | UniProt NCBI |
| PRXL2C | Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1) | 3 | UniProt NCBI |
| TOP1MT | DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1) | 5 | UniProt NCBI |
| JAM3 | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | 5 | UniProt NCBI |
| ARHGEF37 | Rho guanine nucleotide exchange factor 37 | 2 | UniProt NCBI |
| JAM2 | Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) | 5 | UniProt NCBI |
| CEP89 | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | 5 | UniProt NCBI |
| CITED2 | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) | 5 | UniProt NCBI |
| FBF1 | Fas-binding factor 1 (FBF-1) (Protein albatross) | 5 | UniProt NCBI |
| FHOD1 | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | 5 | UniProt NCBI |
| ICA1 | Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202733 | 0.0188494987968 | 0.25 | JAM2 PICK1 JAM3 | Cell surface interactions at the vascular wall |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ICA1 | PICK1 | 0.999 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PICK1 | PRXL2C | 0.998 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PICK1 | ICA1L | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CEP89 | PICK1 | 0.989 | 0.0683846153846 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TOP1MT | CEP89 | 0.973 | 0.126 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PICK1 | JAM2 | 0.953 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ARHGEF37 | PICK1 | 0.924 | bioplex3_WMM WMM_only bioplex_WMM | ||
| ICA1L | PRXL2C | 0.906 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CEP89 | ICA1L | 0.902 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ICA1 | PRXL2C | 0.902 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| ICA1 | ICA1L | 0.902 |
mutually_exclusive (Q9NRD5)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CEP89 | PRXL2C | 0.902 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| JAM3 | PICK1 | 0.886 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FHOD1 | PICK1 | 0.859 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PICK1 | FBF1 | 0.846 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CITED2 | PICK1 | 0.843 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CEP89 | ICA1 | 0.59 | 0.204 | bioplex_WMM bioplex3_WMM WMM_only | |
| JAM3 | PRXL2C | 0.572 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| JAM3 | ICA1L | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ICA1L | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| CEP89 | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| PRXL2C | FBF1 | 0.415 | bioplex3_WMM WMM_only | ||
| FHOD1 | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| JAM3 | CITED2 | 0.415 | bioplex3_WMM WMM_only | ||
| ICA1L | FBF1 | 0.415 | bioplex3_WMM WMM_only | ||
| CITED2 | FBF1 | 0.415 | bioplex3_WMM WMM_only | ||
| ICA1 | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| JAM3 | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| CITED2 | PRXL2C | 0.415 | bioplex3_WMM WMM_only | ||
| JAM2 | FBF1 | 0.415 | bioplex3_WMM WMM_only | ||
| CITED2 | ICA1L | 0.415 | bioplex3_WMM WMM_only | ||
| PRXL2C | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| CITED2 | JAM2 | 0.415 | bioplex3_WMM WMM_only | ||
| FHOD1 | ICA1L | 0.355 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FHOD1 | PRXL2C | 0.355 | 0.026 | bioplex_WMM bioplex3_WMM WMM_only | |
| ICA1 | CITED2 | 0.274 | bioplex3_WMM WMM_only | ||
| CEP89 | CITED2 | 0.25 | bioplex3_WMM WMM_only | ||
| CITED2 | FHOD1 | 0.21 | bioplex3_WMM WMM_only | ||
| JAM3 | ICA1 | 0.172 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| JAM3 | CEP89 | 0.164 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| CEP89 | FHOD1 | 0.101 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| JAM3 | FBF1 | 0.088 | bioplex3_WMM gupta_WMM WMM_only | ||
| ICA1 | FBF1 | 0.079 | bioplex3_WMM WMM_only | ||
| JAM3 | FHOD1 | 0.077 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| ICA1 | FHOD1 | 0.075 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| CEP89 | FBF1 | 0.024 | bioplex3_WMM gupta_WMM WMM_only | ||
| FHOD1 | FBF1 | 0.016 | bioplex3_WMM gupta_WMM WMM_only |
Related Complexes