hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12884.1
Complex Portal: CPX-22605
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OSCAR | Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3) | 5 | UniProt NCBI |
| COL8A1 | Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] | 5 | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | 5 | UniProt NCBI |
| COL2A1 | Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] | 5 | UniProt NCBI |
| COL5A1 | Collagen alpha-1(V) chain | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 1.16894660556e-08 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 7.60097837806e-08 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 9.02804991004e-08 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Collagen degradation |
| KEGG:04974 | 1.10030772082e-07 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Protein digestion and absorption |
| REAC:R-HSA-1650814 | 1.15337100464e-07 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Collagen biosynthesis and modifying enzymes |
| GO:0098644 | 1.31622611039e-07 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | complex of collagen trimers |
| REAC:R-HSA-216083 | 2.53618197426e-07 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Integrin cell surface interactions |
| REAC:R-HSA-1474290 | 4.37814665439e-07 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Collagen formation |
| GO:0005581 | 1.16377978294e-06 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | collagen trimer |
| REAC:R-HSA-1474228 | 2.03059825145e-06 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Degradation of the extracellular matrix |
| GO:0030020 | 3.12047922974e-06 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-419037 | 9.10580767182e-06 | 0.6 | COL4A2 COL2A1 COL5A1 | NCAM1 interactions |
| REAC:R-HSA-375165 | 3.5683276241e-05 | 0.6 | COL4A2 COL2A1 COL5A1 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-1474244 | 4.62662759694e-05 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | Extracellular matrix organization |
| REAC:R-HSA-3000171 | 5.3727974474e-05 | 0.6 | COL4A2 COL2A1 COL5A1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-186797 | 5.3727974474e-05 | 0.6 | COL4A2 COL2A1 COL5A1 | Signaling by PDGF |
| REAC:R-HSA-3000178 | 9.57519237992e-05 | 0.6 | COL4A2 COL2A1 COL5A1 | ECM proteoglycans |
| GO:0005201 | 0.000872617123619 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | extracellular matrix structural constituent |
| WP:WP2911 | 0.00089796435942 | 0.4 | COL4A2 COL5A1 | miRNA targets in ECM and membrane receptors |
| HPA:0461433 | 0.00187254522974 | 0.4 | COL8A1 COL4A2 | skin 1; extracellular matrix[High] |
| HPA:0471433 | 0.00205060198562 | 0.4 | COL8A1 COL4A2 | skin 2; extracellular matrix[High] |
| WP:WP3932 | 0.00295696208302 | 0.6 | COL4A2 COL2A1 COL5A1 | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-8874081 | 0.00418294558639 | 0.4 | COL2A1 COL5A1 | MET activates PTK2 signaling |
| GO:0030198 | 0.00458954735571 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | extracellular matrix organization |
| GO:0043062 | 0.00458954735571 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | extracellular structure organization |
| GO:0045229 | 0.00480818953079 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | external encapsulating structure organization |
| HPA:0461432 | 0.00599276207912 | 0.4 | COL8A1 COL4A2 | skin 1; extracellular matrix[>=Medium] |
| GO:0035987 | 0.00627040828674 | 0.6 | COL8A1 COL5A1 COL4A2 | endodermal cell differentiation |
| HPA:0471432 | 0.00696038747472 | 0.4 | COL8A1 COL4A2 | skin 2; extracellular matrix[>=Medium] |
| REAC:R-HSA-8875878 | 0.00849065158197 | 0.4 | COL2A1 COL5A1 | MET promotes cell motility |
| GO:0001706 | 0.0094606249379 | 0.6 | COL8A1 COL5A1 COL4A2 | endoderm formation |
| HPA:0461431 | 0.00989213643332 | 0.4 | COL8A1 COL4A2 | skin 1; extracellular matrix[>=Low] |
| KEGG:04512 | 0.00996128881886 | 0.4 | COL4A2 COL2A1 | ECM-receptor interaction |
| GO:0007492 | 0.011813517648 | 0.6 | COL8A1 COL5A1 COL4A2 | endoderm development |
| HPA:0471431 | 0.0124256023723 | 0.4 | COL8A1 COL4A2 | skin 2; extracellular matrix[>=Low] |
| GO:0005788 | 0.0196468946878 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | endoplasmic reticulum lumen |
| GO:0048598 | 0.0199678668185 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | embryonic morphogenesis |
| HP:0032153 | 0.0224351839587 | 0.4 | COL2A1 COL5A1 | Joint subluxation |
| GO:0001704 | 0.0327001087246 | 0.6 | COL8A1 COL5A1 COL4A2 | formation of primary germ layer |
| REAC:R-HSA-6806834 | 0.035336387757 | 0.4 | COL2A1 COL5A1 | Signaling by MET |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | COL4A2 COL2A1 COL5A1 | Signaling by Receptor Tyrosine Kinases |
| HP:0002761 | 0.0425110382594 | 0.4 | COL2A1 COL5A1 | Generalized joint hypermobility |
| GO:0062023 | 0.043388817269 | 0.8 | COL8A1 COL5A1 COL2A1 COL4A2 | collagen-containing extracellular matrix |
| HP:0001083 | 0.0472853555832 | 0.4 | COL2A1 COL5A1 | Ectopia lentis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COL5A1 | COL2A1 | 0.946 | 0.338 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL4A2 | COL5A1 | 0.928 | 0.262 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL8A1 | COL2A1 | 0.903 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL4A2 | COL2A1 | 0.898 | 0.194 | bioplex_WMM bioplex3_WMM WMM_only | |
| COL2A1 | OSCAR | 0.855 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COL5A1 | COL8A1 | 0.709 | 0.284 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| COL4A2 | COL8A1 | 0.388 | 0.212 | bioplex3_HEK293 bioplex3_WMM WMM_only |
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