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hu.MAP 3.0
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hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):
Enrichment (ex. cilium):
Protein (ex. Centrosomal protein):
Complex:
huMAP3_12888.1
Complex Portal:
CPX-16610
Confidence:
Medium
?
Proteins
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Genename
Protein Name
Uniprot Annotation Score
Links
CUL3
Cullin-3 (CUL-3)
5
UniProt
NCBI
DCUN1D1
DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
5
UniProt
NCBI
DCUN1D2
DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
5
UniProt
NCBI
KLHL12
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
5
UniProt
NCBI
KLHL3
Kelch-like protein 3
5
UniProt
NCBI
PXDNL
Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2)
5
UniProt
NCBI
RHOBTB1
Rho-related BTB domain-containing protein 1
4
UniProt
NCBI
USP25
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
5
UniProt
NCBI
Showing 1 to 8 of 8 entries
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Enrichments
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Term ID
Corrected Pval
Fraction Complex Coverage
Proteins
Term Name
CORUM:6815
2.39226645298e-05
0.25
CUL3 KLHL12
DRD4-KLHL12-CUL3 complex
CORUM:6267
2.39226645298e-05
0.25
KLHL3 CUL3
Ubiquitin E3 ligase (CUL3, KLHL3)
CORUM:6266
2.39226645298e-05
0.25
KLHL3 CUL3
Ubiquitin E3 ligase (CUL3, KLHL3, WNK4)
CORUM:6233
7.17483486175e-05
0.25
KLHL3 CUL3
Ubiquitin E3 ligase (CUL3, KLHL3, WNK1)
CORUM:7522
0.000143457417375
0.25
CUL3 KLHL12
Ubiquitin E3 ligase (CUL3, KLHL12, PEF1, PDCD6)
HP:0011423
0.000677898190386
0.25
KLHL3 CUL3
Hyperchloremia
REAC:R-HSA-8951664
0.000776134882135
0.5
KLHL3 CUL3 DCUN1D2 DCUN1D1
Neddylation
HP:0011422
0.00135542525381
0.25
KLHL3 CUL3
Abnormal blood chloride concentration
HP:0008242
0.00225842370351
0.25
KLHL3 CUL3
Pseudohypoaldosteronism
HP:0001995
0.0063183945919
0.25
KLHL3 CUL3
Hyperchloremic acidosis
Showing 1 to 10 of 19 entries
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Edges
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Protein 1
Protein 2
Score
?
ProteomeHD
?
Interface Overlap
?
Evidence
?
DCUN1D1
CUL3
0.993
0.228
structurally_consistent (dimer)
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
KLHL3
PXDNL
0.983
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL12
KLHL3
0.981
mutually_exclusive (O95198)
structurally_consistent (dimer)
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL3
CUL3
0.98
structurally_consistent (dimer)
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CUL3
RHOBTB1
0.97
structurally_consistent (dimer)
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CUL3
PXDNL
0.966
bioplex_WMM bioplex3_WMM WMM_only
RHOBTB1
PXDNL
0.953
bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL12
USP25
0.902
0.122
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CUL3
USP25
0.893
0.396
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KLHL12
CUL3
0.884
0.207333333333
structurally_consistent (dimer)
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
Showing 1 to 10 of 19 entries
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Related Complexes
Genename
Complexes
USP25
huMAP3_03808.1
huMAP3_06607.1
huMAP3_07744.1
huMAP3_10939.1
huMAP3_11515.1
huMAP3_12888.1
huMAP3_13664.1
huMAP3_14151.1
huMAP3_14727.1
KLHL12
huMAP3_00461.1
huMAP3_00845.1
huMAP3_04370.1
huMAP3_08531.1
huMAP3_09489.1
huMAP3_10580.1
huMAP3_11066.1
huMAP3_12888.1
huMAP3_12937.1
huMAP3_13639.1
KLHL3
huMAP3_00845.1
huMAP3_04583.1
huMAP3_06240.1
huMAP3_07328.1
huMAP3_08531.1
huMAP3_10580.1
huMAP3_11066.1
huMAP3_11818.1
huMAP3_12888.1
DCUN1D2
huMAP3_02920.1
huMAP3_05999.1
huMAP3_06936.1
huMAP3_11515.1
huMAP3_12888.1
huMAP3_13416.1
huMAP3_13664.1
huMAP3_14151.1
huMAP3_14727.1
DCUN1D1
huMAP3_01275.1
huMAP3_05842.1
huMAP3_05855.1
huMAP3_07859.1
huMAP3_10957.1
huMAP3_12888.1
huMAP3_13857.1
huMAP3_14813.1
RHOBTB1
huMAP3_09686.1
huMAP3_10887.1
huMAP3_12888.1
huMAP3_14528.1
CUL3
huMAP3_02073.1
huMAP3_07590.1
huMAP3_08550.1
huMAP3_09779.1
huMAP3_12888.1
huMAP3_13639.1
huMAP3_14528.1
PXDNL
huMAP3_09686.1
huMAP3_10113.1
huMAP3_12888.1
huMAP3_14528.1