hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12888.1

Complex Portal: CPX-16610

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
USP25	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)	5	UniProt NCBI
KLHL12	Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)	5	UniProt NCBI
KLHL3	Kelch-like protein 3	5	UniProt NCBI
DCUN1D2	DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)	5	UniProt NCBI
DCUN1D1	DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)	5	UniProt NCBI
RHOBTB1	Rho-related BTB domain-containing protein 1	4	UniProt NCBI
CUL3	Cullin-3 (CUL-3)	5	UniProt NCBI
PXDNL	Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6815	2.39226645298e-05	0.25	KLHL12 CUL3	DRD4-KLHL12-CUL3 complex
CORUM:6267	2.39226645298e-05	0.25	KLHL3 CUL3	Ubiquitin E3 ligase (CUL3, KLHL3)
CORUM:6266	2.39226645298e-05	0.25	KLHL3 CUL3	Ubiquitin E3 ligase (CUL3, KLHL3, WNK4)
CORUM:6233	7.17483486175e-05	0.25	KLHL3 CUL3	Ubiquitin E3 ligase (CUL3, KLHL3, WNK1)
CORUM:7522	0.000143457417375	0.25	KLHL12 CUL3	Ubiquitin E3 ligase (CUL3, KLHL12, PEF1, PDCD6)
HP:0011423	0.000677898190386	0.25	KLHL3 CUL3	Hyperchloremia
REAC:R-HSA-8951664	0.000776134882135	0.5	DCUN1D1 CUL3 KLHL3 DCUN1D2	Neddylation
HP:0011422	0.00135542525381	0.25	KLHL3 CUL3	Abnormal blood chloride concentration
HP:0008242	0.00225842370351	0.25	KLHL3 CUL3	Pseudohypoaldosteronism
HP:0001995	0.0063183945919	0.25	KLHL3 CUL3	Hyperchloremic acidosis
HP:0004918	0.0063183945919	0.25	KLHL3 CUL3	Hyperchloremic metabolic acidosis
GO:0000151	0.00642005344206	0.625	DCUN1D1 CUL3 KLHL12 DCUN1D2 KLHL3	ubiquitin ligase complex
GO:0070647	0.0097228404372	0.75	DCUN1D1 KLHL3 USP25 CUL3 KLHL12 DCUN1D2	protein modification by small protein conjugation or removal
GO:0097602	0.0108360428077	0.375	DCUN1D1 KLHL3 DCUN1D2	cullin family protein binding
REAC:R-HSA-9013422	0.0140328389809	0.25	RHOBTB1 CUL3	RHOBTB1 GTPase cycle
GO:0043687	0.0143560119467	0.75	DCUN1D1 KLHL3 USP25 CUL3 KLHL12 DCUN1D2	post-translational protein modification
REAC:R-HSA-9706574	0.0328938418336	0.25	RHOBTB1 CUL3	RHOBTB GTPase Cycle
REAC:R-HSA-597592	0.0405127359976	0.625	USP25 DCUN1D1 CUL3 KLHL3 DCUN1D2	Post-translational protein modification
GO:0031463	0.0487399472212	0.375	CUL3 KLHL12 KLHL3	Cul3-RING ubiquitin ligase complex

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
DCUN1D1	CUL3	0.993	0.228	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
KLHL3	PXDNL	0.983			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL12	KLHL3	0.981		mutually_exclusive (O95198) structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL3	CUL3	0.98		structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CUL3	RHOBTB1	0.97		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CUL3	PXDNL	0.966			bioplex_WMM bioplex3_WMM WMM_only
RHOBTB1	PXDNL	0.953			bioplex3_WMM bioplex3_HCT116 WMM_only
KLHL12	USP25	0.902	0.122		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CUL3	USP25	0.893	0.396		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
KLHL12	CUL3	0.884	0.207333333333	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DCUN1D2	USP25	0.883			bioplex3_HEK293 bioplex3_WMM WMM_only
USP25	PXDNL	0.619			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CUL3	DCUN1D2	0.258			bioplex3_HEK293 bioplex3_WMM WMM_only
DCUN1D1	RHOBTB1	0.143		structurally_consistent (Q13618)	bioplex_WMM bioplex3_WMM WMM_only
KLHL12	DCUN1D1	0.092	0.144	structurally_consistent (Q13618)	bioplex_WMM bioplex3_WMM WMM_only
KLHL12	RHOBTB1	0.088		mutually_exclusive (Q13618)	bioplex_WMM bioplex3_WMM WMM_only
KLHL12	PXDNL	0.077			bioplex_WMM bioplex3_WMM WMM_only
KLHL12	DCUN1D2	0.069			bioplex3_HEK293 bioplex3_WMM WMM_only
DCUN1D1	PXDNL	0.009			fraction

Related Complexes

Genename	Complexes
USP25	huMAP3_03808.1 huMAP3_06607.1 huMAP3_07744.1 huMAP3_10939.1 huMAP3_11515.1 huMAP3_12888.1 huMAP3_13664.1 huMAP3_14151.1 huMAP3_14727.1
KLHL12	huMAP3_00461.1 huMAP3_00845.1 huMAP3_04370.1 huMAP3_08531.1 huMAP3_09489.1 huMAP3_10580.1 huMAP3_11066.1 huMAP3_12888.1 huMAP3_12937.1 huMAP3_13639.1
KLHL3	huMAP3_00845.1 huMAP3_04583.1 huMAP3_06240.1 huMAP3_07328.1 huMAP3_08531.1 huMAP3_10580.1 huMAP3_11066.1 huMAP3_11818.1 huMAP3_12888.1
DCUN1D2	huMAP3_02920.1 huMAP3_05999.1 huMAP3_06936.1 huMAP3_11515.1 huMAP3_12888.1 huMAP3_13416.1 huMAP3_13664.1 huMAP3_14151.1 huMAP3_14727.1
DCUN1D1	huMAP3_01275.1 huMAP3_05842.1 huMAP3_05855.1 huMAP3_07859.1 huMAP3_10957.1 huMAP3_12888.1 huMAP3_13857.1 huMAP3_14813.1
RHOBTB1	huMAP3_09686.1 huMAP3_10887.1 huMAP3_12888.1 huMAP3_14528.1
CUL3	huMAP3_02073.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_12888.1 huMAP3_13639.1 huMAP3_14528.1
PXDNL	huMAP3_09686.1 huMAP3_10113.1 huMAP3_12888.1 huMAP3_14528.1