hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12903.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLCO1B3 | Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) | 5 | UniProt NCBI |
| SLCO1B1 | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) | 5 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031811 | 1.26540735158e-05 | 0.666666666667 | SLCO1B3 SLCO1B1 | Bilirubinuria |
| WP:WP5396 | 5.0954861614e-05 | 0.666666666667 | SLCO1B3 SLCO1B1 | Enterohepatic circulation of bile acids |
| WP:WP5368 | 5.0954861614e-05 | 0.666666666667 | SLCO1B3 SLCO1B1 | Sulfatase and aromatase pathway |
| REAC:R-HSA-879518 | 0.000102258192243 | 0.666666666667 | SLCO1B3 SLCO1B1 | Transport of organic anions |
| HP:0001046 | 0.000126523416231 | 0.666666666667 | SLCO1B3 SLCO1B1 | Intermittent jaundice |
| WP:WP5176 | 0.000153947718176 | 0.666666666667 | SLCO1B3 SLCO1B1 | Disorders of bile acid synthesis and biliary transport |
| HP:0032106 | 0.000189776464884 | 0.666666666667 | SLCO1B3 SLCO1B1 | Conjunctival icterus |
| REAC:R-HSA-9754706 | 0.000190864539041 | 0.666666666667 | SLCO1B3 SLCO1B1 | Atorvastatin ADME |
| HP:0010473 | 0.000354217072454 | 0.666666666667 | SLCO1B3 SLCO1B1 | Porphyrinuria |
| REAC:R-HSA-159418 | 0.000449812862905 | 0.666666666667 | SLCO1B3 SLCO1B1 | Recycling of bile acids and salts |
| REAC:R-HSA-189483 | 0.000449812862905 | 0.666666666667 | SLCO1B3 SLCO1B1 | Heme degradation |
| HP:0010984 | 0.000986522412937 | 0.666666666667 | SLCO1B3 SLCO1B1 | Digenic inheritance |
| KEGG:04976 | 0.00125862804941 | 0.666666666667 | SLCO1B3 SLCO1B1 | Bile secretion |
| REAC:R-HSA-189445 | 0.00157362645287 | 0.666666666667 | SLCO1B3 SLCO1B1 | Metabolism of porphyrins |
| REAC:R-HSA-194068 | 0.00276488364952 | 0.666666666667 | SLCO1B3 SLCO1B1 | Bile acid and bile salt metabolism |
| REAC:R-HSA-425397 | 0.0033773260227 | 0.666666666667 | SLCO1B3 SLCO1B1 | Transport of vitamins, nucleosides, and related molecules |
| HP:0002908 | 0.00379223870168 | 0.666666666667 | SLCO1B3 SLCO1B1 | Conjugated hyperbilirubinemia |
| REAC:R-HSA-5619102 | 0.0164154902665 | 0.666666666667 | SLCO1B3 SLCO1B1 | SLC transporter disorders |
| REAC:R-HSA-556833 | 0.0177385429708 | 1.0 | ORMDL2 SLCO1B3 SLCO1B1 | Metabolism of lipids |
| REAC:R-HSA-9748784 | 0.0220121799777 | 0.666666666667 | SLCO1B3 SLCO1B1 | Drug ADME |
| GO:0015347 | 0.0294899169624 | 0.666666666667 | SLCO1B3 SLCO1B1 | sodium-independent organic anion transmembrane transporter activity |
| HP:0001426 | 0.0313463863633 | 0.666666666667 | SLCO1B3 SLCO1B1 | Non-Mendelian inheritance |
| GO:0043252 | 0.0393180950424 | 0.666666666667 | SLCO1B3 SLCO1B1 | sodium-independent organic anion transport |
| REAC:R-HSA-5619058 | 0.0498224659464 | 0.333333333333 | SLCO1B3 | Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) |
| REAC:R-HSA-5619110 | 0.0498224659464 | 0.333333333333 | SLCO1B1 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SLCO1B3 | SLCO1B1 | 0.992 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SLCO1B1 | ORMDL2 | 0.945 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes