hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12906.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | 5 | UniProt NCBI |
| ARMS2 | Age-related maculopathy susceptibility protein 2 | 3 | UniProt NCBI |
| PAGE2B | Putative G antigen family E member 3 (Prostate-associated gene 2B protein) (PAGE-2B) | 2 | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00785 | 1.62014347596e-06 | 0.5 | OGDH OGDHL DLST | Lipoic acid metabolism |
| KEGG:00020 | 8.04611191878e-06 | 0.5 | OGDH OGDHL DLST | Citrate cycle (TCA cycle) |
| KEGG:01210 | 8.04611191878e-06 | 0.5 | OGDH OGDHL DLST | 2-Oxocarboxylic acid metabolism |
| GO:0045252 | 6.72425931667e-05 | 0.5 | OGDH OGDHL DLST | oxoglutarate dehydrogenase complex |
| CORUM:7267 | 0.000102488289015 | 0.333333333333 | DLST OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| GO:0045240 | 0.000316805542726 | 0.5 | OGDH OGDHL DLST | dihydrolipoyl dehydrogenase complex |
| KEGG:01200 | 0.000356793103324 | 0.5 | OGDH OGDHL DLST | Carbon metabolism |
| GO:0006103 | 0.000548960443183 | 0.5 | OGDH OGDHL DLST | 2-oxoglutarate metabolic process |
| WP:WP2453 | 0.00120604069052 | 0.333333333333 | DLST OGDH | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| GO:0045239 | 0.00130441648129 | 0.5 | OGDH OGDHL DLST | tricarboxylic acid cycle enzyme complex |
| REAC:R-HSA-71064 | 0.0014177632075 | 0.333333333333 | DLST OGDH | Lysine catabolism |
| WP:WP78 | 0.00153714048185 | 0.333333333333 | DLST OGDH | TCA cycle aka Krebs or citric acid cycle |
| GO:0006099 | 0.00387837112504 | 0.5 | OGDH OGDHL DLST | tricarboxylic acid cycle |
| REAC:R-HSA-71403 | 0.00540340354533 | 0.333333333333 | DLST OGDH | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 0.00771351163082 | 0.333333333333 | DLST OGDH | Glyoxylate metabolism and glycine degradation |
| WP:WP5352 | 0.0108030732892 | 0.333333333333 | OGDHL DLST | 10q11 21q11 23 copy number variation syndrome |
| GO:0004591 | 0.0210651876021 | 0.333333333333 | OGDHL OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| WP:WP3925 | 0.0337850948883 | 0.333333333333 | DLST OGDH | Amino acid metabolism |
| REAC:R-HSA-71406 | 0.0339259639772 | 0.333333333333 | DLST OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0106077 | 0.042122686785 | 0.333333333333 | DLST OGDH | histone succinylation |
| GO:0018335 | 0.042122686785 | 0.333333333333 | DLST OGDH | protein succinylation |
| WP:WP4932 | 0.0451642815361 | 0.333333333333 | DLST OGDH | 7q11 23 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.658 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM |
| OGDHL | DLST | 0.999 | 0.74 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | OGDH | 0.998 | 0.966 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| OGDHL | PAGE2B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCAIM | DLST | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| OGDHL | TCAIM | 0.956 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| OGDHL | ARMS2 | 0.811 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAGE2B | DLST | 0.704 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OGDH | ARMS2 | 0.13 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAGE2B | OGDH | 0.11 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DLST | ARMS2 | 0.072 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PAGE2B | TCAIM | 0.055 | bioplex3_WMM WMM_only |
Related Complexes