hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12909.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS25 | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) | 5 | UniProt NCBI |
| CHMP6 | Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20) | 5 | UniProt NCBI |
| SNF8 | Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) | 5 | UniProt NCBI |
| VPS36 | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1187 | 7.01606139244e-10 | 0.75 | SNF8 VPS25 VPS36 | ESCRT-II complex |
| REAC:R-HSA-917729 | 2.63174325842e-09 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0032511 | 1.92476895832e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | late endosome to vacuole transport via multivesicular body sorting pathway |
| GO:0036452 | 3.32854782266e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | ESCRT complex |
| REAC:R-HSA-9610379 | 3.6149867397e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | HCMV Late Events |
| GO:0000814 | 3.84480164306e-07 | 0.75 | SNF8 VPS25 VPS36 | ESCRT II complex |
| GO:0045324 | 8.27926934703e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | late endosome to vacuole transport |
| GO:0036258 | 8.27926934703e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | multivesicular body assembly |
| GO:0036257 | 9.46202211089e-07 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | multivesicular body organization |
| GO:0043162 | 1.07671286089e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0032509 | 1.22027457568e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | endosome transport via multivesicular body sorting pathway |
| REAC:R-HSA-9609646 | 1.55902386745e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | HCMV Infection |
| GO:0071985 | 2.40471134793e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | multivesicular body sorting pathway |
| GO:0090148 | 2.6646801423e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | membrane fission |
| KEGG:04144 | 2.71547092057e-06 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Endocytosis |
| GO:0007032 | 4.37773767152e-05 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | endosome organization |
| GO:0043328 | 0.000215165225046 | 0.75 | SNF8 VPS25 VPS36 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0007034 | 0.000317929863268 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | vacuolar transport |
| REAC:R-HSA-199991 | 0.000426838992032 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000530772712934 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Vesicle-mediated transport |
| REAC:R-HSA-9824446 | 0.000968971416592 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Viral Infection Pathways |
| REAC:R-HSA-5663205 | 0.00221430492734 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Infectious disease |
| GO:0016197 | 0.00379124230895 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | endosomal transport |
| GO:0016236 | 0.00595686338265 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | macroautophagy |
| GO:0016050 | 0.00669062030536 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | vesicle organization |
| GO:0072666 | 0.0089837173405 | 0.75 | SNF8 VPS25 VPS36 | establishment of protein localization to vacuole |
| GO:0010008 | 0.0147371035162 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | endosome membrane |
| REAC:R-HSA-1643685 | 0.0193799289378 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | Disease |
| GO:0072665 | 0.0258660780327 | 0.75 | SNF8 VPS25 VPS36 | protein localization to vacuole |
| GO:0031902 | 0.0302857026499 | 0.75 | SNF8 CHMP6 VPS36 | late endosome membrane |
| GO:0010256 | 0.0394366436807 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | endomembrane system organization |
| GO:0006914 | 0.0431855442038 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | autophagy |
| GO:0061919 | 0.0431855442038 | 1.0 | SNF8 VPS36 VPS25 CHMP6 | process utilizing autophagic mechanism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS25 | VPS36 | 1.0 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction |
| SNF8 | VPS36 | 1.0 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () fraction |
| VPS25 | SNF8 | 1.0 | 0.822 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
| VPS36 | CHMP6 | 0.886 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VPS25 | CHMP6 | 0.851 | 0.038 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SNF8 | CHMP6 | 0.811 | 0.058 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| VPS25 | huMAP3_03029.1 huMAP3_12909.1 |
| CHMP6 | huMAP3_03988.1 huMAP3_06564.1 huMAP3_08679.1 huMAP3_10053.1 huMAP3_12523.1 huMAP3_12909.1 |
| SNF8 | huMAP3_03029.1 huMAP3_12523.1 huMAP3_12909.1 |
| VPS36 | huMAP3_03029.1 huMAP3_12909.1 |