hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12917.1

Complex Portal: CPX-23030

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
VPS37B	Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)	5	UniProt NCBI
MVB12B	Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)	5	UniProt NCBI
VPS37C	Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)	5	UniProt NCBI
TAS2R7	Taste receptor type 2 member 7 (T2R7) (Taste receptor family B member 4) (TRB4)	4	UniProt NCBI
PSPN	Persephin (PSP)	4	UniProt NCBI
PDCD6IP	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	5	UniProt NCBI
TSG101	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	5	UniProt NCBI
UMAD1	UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand)	2	UniProt NCBI
MVB12A	Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)	5	UniProt NCBI
VPS28	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	5	UniProt NCBI
PDCD6	Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)	5	UniProt NCBI
VPS37A	Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)	5	UniProt NCBI
UBAP1	Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-162588	1.08998204166e-20	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	Budding and maturation of HIV virion
REAC:R-HSA-174495	2.04560536279e-20	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Synthesis And Processing Of GAG, GAGPOL Polyproteins
REAC:R-HSA-174490	2.04560536279e-20	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Membrane binding and targetting of GAG proteins
GO:0000813	5.61641098591e-20	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	ESCRT I complex
REAC:R-HSA-175474	8.76154396884e-20	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Assembly Of The HIV Virion
GO:0036258	8.57146618951e-18	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	multivesicular body assembly
GO:0036257	1.19225749773e-17	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	multivesicular body organization
GO:0043328	1.6033625463e-17	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
REAC:R-HSA-917729	3.9675575539e-17	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Endosomal Sorting Complex Required For Transport (ESCRT)
REAC:R-HSA-9615710	7.12575951524e-17	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Late endosomal microautophagy
GO:0032511	3.97646762011e-16	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	late endosome to vacuole transport via multivesicular body sorting pathway
GO:0046755	6.09539364934e-16	0.615384615385	VPS37C TSG101 VPS37B PDCD6IP VPS28 MVB12A VPS37A MVB12B	viral budding
GO:0036452	1.3437532986e-15	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	ESCRT complex
GO:0045324	9.78308557841e-15	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	late endosome to vacuole transport
GO:0019068	1.30401399129e-14	0.615384615385	VPS37C TSG101 VPS37B PDCD6IP VPS28 MVB12A VPS37A MVB12B	virion assembly
GO:0043162	1.72077400468e-14	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0032509	2.24955726117e-14	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	endosome transport via multivesicular body sorting pathway
REAC:R-HSA-162599	4.99136249988e-14	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	Late Phase of HIV Life Cycle
GO:0071985	9.51109490272e-14	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	multivesicular body sorting pathway
GO:0007032	1.09559264327e-13	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	endosome organization
REAC:R-HSA-162587	1.12885496248e-13	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	HIV Life Cycle
GO:0090148	1.18132127364e-13	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	membrane fission
GO:0039702	2.34603166367e-13	0.538461538462	VPS37C TSG101 VPS37B VPS28 PDCD6IP MVB12A VPS37A	viral budding via host ESCRT complex
GO:0072666	1.09181160263e-12	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	establishment of protein localization to vacuole
REAC:R-HSA-9610379	1.13633770178e-12	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	HCMV Late Events
REAC:R-HSA-162906	6.51218026162e-12	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	HIV Infection
GO:0072665	2.06433945207e-11	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	protein localization to vacuole
REAC:R-HSA-9612973	2.0741168135e-11	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Autophagy
REAC:R-HSA-9609646	2.1972707397e-11	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	HCMV Infection
GO:0016050	8.00274631763e-11	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	vesicle organization
KEGG:04144	2.37405576146e-10	0.615384615385	VPS37C TSG101 VPS37B PDCD6IP VPS28 MVB12A VPS37A MVB12B	Endocytosis
GO:0007034	2.21419611731e-09	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	vacuolar transport
WP:WP4932	1.32445782964e-08	0.461538461538	VPS37C VPS37A VPS37B VPS28 MVB12A TSG101	7q11 23 copy number variation syndrome
CORUM:1192	3.08880131998e-08	0.230769230769	VPS37C TSG101 VPS28	ESCRT-I complex
CORUM:1863	3.08880131998e-08	0.230769230769	VPS37B TSG101 VPS28	TSG101-VPS37B-VPS28 complex
GO:0061024	8.88362349745e-08	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	membrane organization
GO:0019058	9.99853627927e-08	0.615384615385	VPS37C TSG101 VPS37B PDCD6IP VPS28 MVB12A VPS37A MVB12B	viral life cycle
REAC:R-HSA-9824446	2.15326006352e-07	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	Viral Infection Pathways
GO:0016197	3.22365967313e-07	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	endosomal transport
GO:0010256	5.6632290954e-07	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	endomembrane system organization
REAC:R-HSA-5663205	1.33421771934e-06	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	Infectious disease
GO:0006886	1.44115578116e-06	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	intracellular protein transport
REAC:R-HSA-199991	1.57234062968e-06	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Membrane Trafficking
GO:0016032	2.19822873406e-06	0.615384615385	VPS37C TSG101 VPS37B PDCD6IP VPS28 MVB12A VPS37A MVB12B	viral process
REAC:R-HSA-5653656	2.41051087624e-06	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	Vesicle-mediated transport
GO:0072594	4.49036220209e-06	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	establishment of protein localization to organelle
GO:0010008	4.81734507659e-06	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	endosome membrane
GO:0051603	1.02241395114e-05	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	proteolysis involved in protein catabolic process
GO:0005768	4.24898617846e-05	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	endosome
GO:0006508	4.31565950405e-05	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	proteolysis
GO:0048306	4.73835429563e-05	0.384615384615	VPS37B TSG101 PDCD6 PDCD6IP VPS37C	calcium-dependent protein binding
GO:0070925	5.70754699607e-05	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	organelle assembly
GO:0016236	5.72995622242e-05	0.538461538462	VPS37C TSG101 VPS37B VPS28 PDCD6IP MVB12A VPS37A	macroautophagy
GO:0016192	6.39065044967e-05	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	vesicle-mediated transport
GO:0030659	7.07576299035e-05	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	cytoplasmic vesicle membrane
GO:0012506	8.14179111278e-05	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	vesicle membrane
GO:0030163	8.33262430658e-05	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	protein catabolic process
GO:0015031	8.42951485318e-05	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	protein transport
GO:0006511	8.51156427847e-05	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	ubiquitin-dependent protein catabolic process
GO:0019941	9.67108257159e-05	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	modification-dependent protein catabolic process
GO:0043632	0.000114885813528	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	modification-dependent macromolecule catabolic process
REAC:R-HSA-1643685	0.000150764226725	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	Disease
GO:0098796	0.000436883628298	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	membrane protein complex
GO:0051649	0.000629021087222	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	establishment of localization in cell
GO:0045184	0.000898952030743	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	establishment of protein localization
GO:0009057	0.00134354874334	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	macromolecule catabolic process
GO:1901565	0.00143598230743	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	organonitrogen compound catabolic process
GO:0071705	0.00167832635474	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	nitrogen compound transport
GO:0046907	0.00174780540736	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	intracellular transport
GO:0006914	0.00174838831133	0.538461538462	VPS37C TSG101 VPS37B VPS28 PDCD6IP MVB12A VPS37A	autophagy
GO:0061919	0.00174838831133	0.538461538462	VPS37C TSG101 VPS37B VPS28 PDCD6IP MVB12A VPS37A	process utilizing autophagic mechanism
GO:0033365	0.00200410556311	0.615384615385	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A MVB12B	protein localization to organelle
GO:0031410	0.00356320885352	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	cytoplasmic vesicle
GO:0097708	0.00362612809337	0.769230769231	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	intracellular vesicle
GO:0071702	0.00976664070671	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	organic substance transport
GO:0043130	0.0197916537413	0.307692307692	UBAP1 VPS28 TSG101 MVB12A	ubiquitin binding
GO:0098588	0.0219286719866	0.692307692308	VPS37C TSG101 VPS37B VPS28 UBAP1 MVB12A VPS37A PDCD6 MVB12B	bounding membrane of organelle
GO:1901575	0.0304343487355	0.692307692308	VPS37C TSG101 VPS37B PDCD6IP VPS28 UBAP1 MVB12A VPS37A MVB12B	organic substance catabolic process
GO:0019075	0.0365196561665	0.153846153846	MVB12B MVB12A	virus maturation
GO:0032182	0.0460739534529	0.307692307692	UBAP1 VPS28 TSG101 MVB12A	ubiquitin-like protein binding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
MVB12A	VPS28	1.0	0.308	structurally_consistent (dimer)
TSG101	VPS37A	1.0	0.67
TSG101	MVB12A	1.0	0.366
VPS37B	TSG101	1.0	0.252
VPS37B	VPS28	1.0	0.534
VPS28	VPS37A	1.0	0.484
TSG101	VPS28	1.0	0.912
TSG101	UBAP1	1.0	0.07
VPS28	UBAP1	1.0	0.138
MVB12B	VPS28	0.999	0.094
VPS37A	UBAP1	0.999	0.17
TSG101	VPS37C	0.999	0.252
VPS28	VPS37C	0.999	0.164	structurally_consistent (Q96EY5) structurally_consistent (dimer)
PDCD6IP	MVB12A	0.997	0.118
VPS37B	UBAP1	0.997	0.046
VPS37B	MVB12A	0.997	0.268
MVB12A	VPS37C	0.997	0.106	structurally_consistent (Q9UK41) structurally_consistent (dimer)
UMAD1	VPS28	0.996	0.172
VPS37A	VPS37C	0.991	0.082
VPS37B	VPS37C	0.991	0.036
PDCD6IP	VPS37C	0.989	0.134773333333
TSG101	UMAD1	0.988	0.154
VPS37C	UBAP1	0.987	0.072
MVB12A	VPS37A	0.983	0.212
UMAD1	VPS37C	0.983	0.108
PDCD6IP	TSG101	0.982	0.246666666667
UMAD1	MVB12A	0.981	0.054
MVB12A	UBAP1	0.981	0.08
MVB12B	MVB12A	0.972	0.052
PDCD6IP	UMAD1	0.963	0.096
VPS37B	VPS37A	0.962	0.1
MVB12B	VPS37B	0.948	0.126
PDCD6IP	PDCD6	0.943	0.32
TSG101	PDCD6	0.94	0.136
MVB12A	PDCD6	0.934	0.042
MVB12B	UBAP1	0.884	0.06
MVB12A	TAS2R7	0.87
MVB12B	VPS37A	0.866	0.108
VPS37B	UMAD1	0.844	0.062
UMAD1	UBAP1	0.844	0.124
UMAD1	VPS37A	0.844	0.084
MVB12B	TSG101	0.839	0.072
MVB12A	PSPN	0.805
MVB12B	PDCD6IP	0.696	0.046
VPS37C	TAS2R7	0.671
MVB12B	VPS37C	0.63	0.07
PDCD6	VPS28	0.553	0.146
TSG101	TAS2R7	0.532
UMAD1	TAS2R7	0.413
UMAD1	PDCD6	0.404	0.104
PDCD6IP	TAS2R7	0.332
PDCD6	VPS37C	0.313	0.072
PDCD6IP	VPS28	0.193	0.124
PDCD6	PSPN	0.19
PDCD6IP	PSPN	0.118
MVB12B	PDCD6	0.116	0.042
MVB12B	UMAD1	0.089	0.166
TSG101	PSPN	0.053
PDCD6	UBAP1	0.052	0.072
PDCD6	VPS37A	0.029	0.13
PDCD6IP	UBAP1	0.025	0.148
PDCD6	TAS2R7	0.022
VPS37B	PDCD6	0.013	0.054	structurally_consistent (dimer)
VPS37B	PDCD6IP	0.01	0.11
PDCD6IP	VPS37A	0.006	0.356

Related Complexes

Genename	Complexes
VPS37B	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
MVB12B	huMAP3_00501.1 huMAP3_04792.1 huMAP3_06010.1 huMAP3_06241.1 huMAP3_06316.1 huMAP3_07951.1 huMAP3_08364.1 huMAP3_09572.1 huMAP3_10226.1 huMAP3_12917.1 huMAP3_13805.1
VPS37C	huMAP3_06533.1 huMAP3_09572.1 huMAP3_12303.1 huMAP3_12658.1 huMAP3_12917.1 huMAP3_13805.1
TAS2R7	huMAP3_12564.1 huMAP3_12917.1 huMAP3_13805.1 huMAP3_15286.1
PSPN	huMAP3_12917.1 huMAP3_13805.1
PDCD6IP	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06089.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12409.1 huMAP3_12917.1 huMAP3_13805.1
TSG101	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
UMAD1	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
MVB12A	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
VPS28	huMAP3_04792.1 huMAP3_06010.1 huMAP3_06533.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
PDCD6	huMAP3_01795.1 huMAP3_12051.1 huMAP3_12917.1 huMAP3_13805.1
VPS37A	huMAP3_04888.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
UBAP1	huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12917.1

Complex Portal: CPX-23030