hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12923.1

Complex Portal: CPX-13422

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
EP300	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	5	UniProt NCBI
RBL2	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	5	UniProt NCBI
MATCAP1	Microtubule-associated tyrosine carboxypeptidase 1 (EC 3.4.17.17) (Microtubule-associated tyrosine carboxypeptidase)	5	UniProt NCBI
BDH2	Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)	5	UniProt NCBI
CITED2	Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj)	5	UniProt NCBI
RBL1	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)	5	UniProt NCBI
C3orf62	Uncharacterized protein C3orf62	3	UniProt NCBI
CREBBP	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	5	UniProt NCBI
CITED1	Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8866907	3.29426179613e-09	0.444444444444	CITED2 CITED1 EP300 CREBBP	Activation of the TFAP2 (AP-2) family of transcription factors
WP:WP366	3.68386095669e-07	0.555555555556	CITED1 CREBBP RBL1 EP300 RBL2	TGF beta signaling pathway
REAC:R-HSA-8864260	6.37877602254e-07	0.444444444444	CITED2 CITED1 EP300 CREBBP	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
REAC:R-HSA-1234158	1.33765378004e-06	0.333333333333	CITED2 EP300 CREBBP	Regulation of gene expression by Hypoxia-inducible Factor
REAC:R-HSA-9614085	7.54535758839e-06	0.444444444444	CITED2 CREBBP EP300 RBL2	FOXO-mediated transcription
REAC:R-HSA-9614657	2.1343196228e-05	0.333333333333	CITED2 EP300 CREBBP	FOXO-mediated transcription of cell death genes
REAC:R-HSA-6804114	2.59087532521e-05	0.333333333333	RBL1 EP300 RBL2	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
GO:1903846	3.50368755955e-05	0.444444444444	CITED2 CITED1 EP300 CREBBP	positive regulation of cellular response to transforming growth factor beta stimulus
GO:0030511	3.50368755955e-05	0.444444444444	CITED2 CITED1 EP300 CREBBP	positive regulation of transforming growth factor beta receptor signaling pathway
KEGG:04110	6.70046738012e-05	0.444444444444	CREBBP RBL1 EP300 RBL2	Cell cycle
CORUM:4	8.20609246787e-05	0.222222222222	EP300 CREBBP	Multisubunit ACTR coactivator complex
CORUM:571	8.20609246787e-05	0.222222222222	EP300 CREBBP	p300-CBP-p270 complex
HP:0011682	0.00014155117386	0.333333333333	CITED2 EP300 CREBBP	Perimembranous ventricular septal defect
KEGG:05203	0.000153939225096	0.444444444444	CREBBP RBL1 EP300 RBL2	Viral carcinogenesis
CORUM:1471	0.000273361732609	0.222222222222	EP300 RBL2	pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
CORUM:2638	0.000273361732609	0.222222222222	EP300 CREBBP	HES1 promoter corepressor complex
HP:0034227	0.000306458653145	0.222222222222	EP300 CREBBP	Aortic isthmus hypoplasia
HP:0001042	0.000306458653145	0.222222222222	EP300 CREBBP	High axial triradius
HP:0005895	0.000306458653145	0.222222222222	EP300 CREBBP	Radial deviation of thumb terminal phalanx
HP:0008107	0.000306458653145	0.222222222222	EP300 CREBBP	Plantar crease between first and second toes
CORUM:6444	0.000409911647195	0.222222222222	RBL2 RBL1	SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex
CORUM:5118	0.000409911647195	0.222222222222	EP300 RBL2	RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2)
REAC:R-HSA-6791312	0.000536007609173	0.333333333333	RBL1 EP300 RBL2	TP53 Regulates Transcription of Cell Cycle Genes
CORUM:570	0.000573693030134	0.222222222222	EP300 CREBBP	p300-CBP-p270-SWI/SNF complex
REAC:R-HSA-3134973	0.000798060792831	0.222222222222	EP300 CREBBP	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
KEGG:04350	0.000843198484996	0.333333333333	CREBBP EP300 RBL1	TGF-beta signaling pathway
HP:5200232	0.000919082356402	0.222222222222	EP300 CREBBP	Phobia
HP:0000756	0.000919082356402	0.222222222222	EP300 CREBBP	Agoraphobia
HP:0005363	0.000919082356402	0.222222222222	EP300 CREBBP	Humoral immunodeficiency
HP:0006200	0.000919082356402	0.222222222222	EP300 CREBBP	Widened distal phalanges
HP:0008752	0.000919082356402	0.222222222222	EP300 CREBBP	Laryngeal cartilage malformation
HP:0005322	0.000919082356402	0.222222222222	EP300 CREBBP	Prominent nasal septum
KEGG:05165	0.000943854596602	0.444444444444	CREBBP RBL1 EP300 RBL2	Human papillomavirus infection
GO:0003682	0.000964358726778	0.666666666667	RBL2 RBL1 CITED2 EP300 CITED1 CREBBP	chromatin binding
HPA:0301361	0.000973189100113	0.666666666667	BDH2 RBL1 CITED2 EP300 CREBBP RBL2	lung; alveolar cells type I[>=Low]
HP:0010775	0.00183757768757	0.222222222222	EP300 CREBBP	Vascular ring
HP:0011087	0.00183757768757	0.222222222222	EP300 CREBBP	Talon cusp
HP:0410266	0.00183757768757	0.222222222222	EP300 CREBBP	Visceral hemangioma
HP:0001128	0.00183757768757	0.222222222222	EP300 CREBBP	Trichiasis
HP:0031207	0.00183757768757	0.222222222222	EP300 CREBBP	Hepatic hemangioma
KEGG:04068	0.00184766477855	0.333333333333	CREBBP EP300 RBL2	FoxO signaling pathway
REAC:R-HSA-212436	0.00194258475403	0.666666666667	RBL2 RBL1 CITED2 EP300 CITED1 CREBBP	Generic Transcription Pathway
WP:WP53	0.00202353509847	0.222222222222	RBL2 RBL1	ID signaling pathway
REAC:R-HSA-1234174	0.00205183750398	0.333333333333	CITED2 EP300 CREBBP	Cellular response to hypoxia
REAC:R-HSA-9818028	0.00223242997382	0.222222222222	EP300 CREBBP	NFE2L2 regulates pentose phosphate pathway genes
GO:0090100	0.00234919252133	0.444444444444	CITED2 CITED1 EP300 CREBBP	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
HP:0033777	0.00306165140522	0.222222222222	EP300 CREBBP	Supernumerary cusp
HP:0009715	0.00306165140522	0.222222222222	EP300 CREBBP	Papillary cystadenoma of the epididymis
HP:0030421	0.00306165140522	0.222222222222	EP300 CREBBP	Epididymal neoplasm
REAC:R-HSA-9617629	0.00358554253109	0.222222222222	EP300 CREBBP	Regulation of FOXO transcriptional activity by acetylation
WP:WP179	0.00360642845821	0.333333333333	RBL1 EP300 RBL2	Cell cycle
REAC:R-HSA-73857	0.00367767854286	0.666666666667	RBL2 RBL1 CITED2 EP300 CITED1 CREBBP	RNA Polymerase II Transcription
REAC:R-HSA-8941856	0.00438093013445	0.222222222222	EP300 CREBBP	RUNX3 regulates NOTCH signaling
REAC:R-HSA-210744	0.00438093013445	0.222222222222	EP300 CREBBP	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
HP:0002700	0.00459101044859	0.222222222222	EP300 CREBBP	Large foramen magnum
HP:0004411	0.00459101044859	0.222222222222	EP300 CREBBP	Deviated nasal septum
HP:0100852	0.00459101044859	0.222222222222	EP300 CREBBP	Abnormal fear-induced behavior
CORUM:5614	0.00465362752882	0.222222222222	RBL2 RBL1	Emerin complex 32
WP:WP3657	0.0052310849594	0.222222222222	EP300 CREBBP	Hematopoietic stem cell gene regulation by GABP alpha beta complex
REAC:R-HSA-3371568	0.00620898744994	0.222222222222	EP300 CREBBP	Attenuation phase
HP:0011335	0.0064253619375	0.222222222222	EP300 CREBBP	Frontal hirsutism
HP:0030434	0.0064253619375	0.222222222222	EP300 CREBBP	Pilomatrixoma
REAC:R-HSA-918233	0.00724150508664	0.222222222222	EP300 CREBBP	TRAF3-dependent IRF activation pathway
HPA:0301371	0.00724785562608	0.666666666667	BDH2 RBL1 CITED2 EP300 CREBBP RBL2	lung; alveolar cells type II[>=Low]
HPA:0301362	0.00758502645388	0.555555555556	CITED2 CREBBP EP300 BDH2 RBL2	lung; alveolar cells type I[>=Medium]
REAC:R-HSA-74160	0.00759942737987	0.666666666667	RBL2 RBL1 CITED2 EP300 CITED1 CREBBP	Gene expression (Transcription)
REAC:R-HSA-3700989	0.00765511426945	0.444444444444	CREBBP RBL1 EP300 RBL2	Transcriptional Regulation by TP53
REAC:R-HSA-9013695	0.00835291407054	0.222222222222	EP300 CREBBP	NOTCH4 Intracellular Domain Regulates Transcription
REAC:R-HSA-1362300	0.00835291407054	0.222222222222	RBL2 RBL1	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
HP:0002341	0.00856441317229	0.222222222222	EP300 CREBBP	Cervical cord compression
HP:0031251	0.00856441317229	0.222222222222	EP300 CREBBP	Abnormal subclavian artery morphology
REAC:R-HSA-1368082	0.00954313848115	0.222222222222	EP300 CREBBP	RORA activates gene expression
REAC:R-HSA-9818027	0.00954313848115	0.222222222222	EP300 CREBBP	NFE2L2 regulating anti-oxidant/detoxification enzymes
HP:0010314	0.0110078716337	0.222222222222	EP300 CREBBP	Premature thelarche
GO:1903844	0.0121592546484	0.444444444444	CITED2 CITED1 EP300 CREBBP	regulation of cellular response to transforming growth factor beta stimulus
GO:0017015	0.0121592546484	0.444444444444	CITED2 CITED1 EP300 CREBBP	regulation of transforming growth factor beta receptor signaling pathway
REAC:R-HSA-9793380	0.0121597301349	0.222222222222	EP300 CREBBP	Formation of paraxial mesoderm
REAC:R-HSA-1362277	0.0121597301349	0.222222222222	RBL2 RBL1	Transcription of E2F targets under negative control by DREAM complex
REAC:R-HSA-9018519	0.0122778305747	0.333333333333	CITED1 EP300 CREBBP	Estrogen-dependent gene expression
WP:WP3414	0.012380386891	0.222222222222	EP300 CREBBP	Initiation of transcription and translation elongation at the HIV 1 LTR
HP:0009714	0.0137554449829	0.222222222222	EP300 CREBBP	Abnormal epididymis morphology
HP:0007086	0.0137554449829	0.222222222222	EP300 CREBBP	Social and occupational deterioration
HP:0002697	0.0137554449829	0.222222222222	EP300 CREBBP	Parietal foramina
REAC:R-HSA-5621575	0.0150906736209	0.222222222222	EP300 CREBBP	CD209 (DC-SIGN) signaling
REAC:R-HSA-9013508	0.0150906736209	0.222222222222	EP300 CREBBP	NOTCH3 Intracellular Domain Regulates Transcription
WP:WP4241	0.0151103173393	0.222222222222	EP300 CREBBP	Type 2 papillary renal cell carcinoma
GO:0043627	0.0162365457737	0.333333333333	CITED2 EP300 CITED1	response to estrogen
HP:0000273	0.0168068410612	0.222222222222	EP300 CREBBP	Facial grimacing
HP:0000321	0.0168068410612	0.222222222222	EP300 CREBBP	Square face
HP:0010562	0.0168068410612	0.222222222222	EP300 CREBBP	Keloids
KEGG:04330	0.0189437044705	0.222222222222	EP300 CREBBP	Notch signaling pathway
REAC:R-HSA-3371571	0.0200751738188	0.222222222222	EP300 CREBBP	HSF1-dependent transactivation
HP:0010066	0.0201617678902	0.222222222222	EP300 CREBBP	Duplication of phalanx of hallux
HP:0010181	0.0201617678902	0.222222222222	EP300 CREBBP	Duplication of phalanx of toe
HP:0012304	0.0201617678902	0.222222222222	EP300 CREBBP	Hypoplastic aortic arch
REAC:R-HSA-186712	0.0237893486791	0.222222222222	EP300 CREBBP	Regulation of beta-cell development
KEGG:04720	0.0239862693019	0.222222222222	EP300 CREBBP	Long-term potentiation
REAC:R-HSA-1538133	0.0257635620293	0.222222222222	RBL2 RBL1	G0 and Early G1
KEGG:03250	0.0267263448961	0.222222222222	EP300 CREBBP	Viral life cycle - HIV-1
WP:WP560	0.0274127875531	0.222222222222	EP300 CREBBP	TGF beta receptor signaling
HP:0009937	0.0277810467869	0.222222222222	EP300 CREBBP	Facial hirsutism
REAC:R-HSA-69205	0.0278157587689	0.222222222222	RBL2 RBL1	G1/S-Specific Transcription
WP:WP4816	0.0300346853536	0.222222222222	EP300 CREBBP	TGF beta receptor signaling in skeletal dysplasias
HP:0012842	0.0320448157979	0.222222222222	EP300 CREBBP	Skin appendage neoplasm
REAC:R-HSA-933541	0.032153801025	0.222222222222	EP300 CREBBP	TRAF6 mediated IRF7 activation
KEGG:05211	0.0347423807791	0.222222222222	EP300 CREBBP	Renal cell carcinoma
HP:0000559	0.0366109494459	0.222222222222	EP300 CREBBP	Corneal scarring
HP:0001869	0.0366109494459	0.222222222222	EP300 CREBBP	Deep plantar creases
HP:0002699	0.0366109494459	0.222222222222	EP300 CREBBP	Abnormal foramen magnum morphology
HPA:0301372	0.0372867131818	0.555555555556	CITED2 CREBBP EP300 BDH2 RBL2	lung; alveolar cells type II[>=Medium]
REAC:R-HSA-8939211	0.0375559727424	0.333333333333	CITED1 EP300 CREBBP	ESR-mediated signaling
HP:0002869	0.0414791566521	0.222222222222	EP300 CREBBP	Flared iliac wing
HP:0006349	0.0414791566521	0.222222222222	EP300 CREBBP	Agenesis of permanent teeth
HP:0009889	0.0414791566521	0.222222222222	EP300 CREBBP	Localized hirsutism
HP:0000387	0.0414791566521	0.222222222222	EP300 CREBBP	Absent earlobe
WP:WP5180	0.0432890882108	0.222222222222	RBL2 RBL1	DYRK1A involvement regarding cell proliferation in brain development
HP:0010059	0.0466491465176	0.222222222222	EP300 CREBBP	Broad hallux phalanx
HP:0031546	0.0482177591518	0.333333333333	CITED2 EP300 CREBBP	Cardiac conduction abnormality
REAC:R-HSA-2173796	0.0497823629923	0.222222222222	EP300 RBL1	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
WP:WP3651	0.0499409119424	0.222222222222	EP300 CREBBP	Pathways affected in adenoid cystic carcinoma
CORUM:5198	0.0499842271994	0.111111111111	CREBBP	CBP-RARA-RXRA-DNA complex, ligand stimulated

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
BDH2	CITED1	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
EP300	CITED1	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CREBBP	CITED1	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
EP300	CREBBP	0.999	0.476	bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM
RBL2	RBL1	0.996	0.118	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
MATCAP1	CITED1	0.987		bioplex3_HEK293 bioplex3_WMM WMM_only
RBL2	CITED1	0.975		bioplex3_HEK293 bioplex3_WMM WMM_only
RBL1	CITED1	0.94		bioplex3_HEK293 bioplex3_WMM WMM_only
CREBBP	C3orf62	0.908		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CREBBP	BDH2	0.905	0.024	bioplex3_WMM WMM_only
EP300	RBL1	0.877	0.323130434783	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
RBL2	CREBBP	0.846	0.362	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
EP300	BDH2	0.84	0.056	bioplex3_WMM WMM_only
EP300	C3orf62	0.831		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EP300	CITED2	0.83		hein_WMM hein ()
RBL1	CREBBP	0.828	0.307536384977	bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
EP300	RBL2	0.482	0.226	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
CREBBP	MATCAP1	0.415		bioplex3_WMM WMM_only
MATCAP1	BDH2	0.415		bioplex3_WMM WMM_only
RBL1	MATCAP1	0.278		bioplex3_WMM WMM_only
EP300	MATCAP1	0.254		bioplex3_WMM WMM_only
RBL2	MATCAP1	0.25		bioplex3_WMM WMM_only
RBL1	C3orf62	0.104		bioplex () bioplex_WMM
RBL1	BDH2	0.093	0.014	bioplex3_WMM WMM_only
RBL2	BDH2	0.078	0.036	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
EP300	huMAP3_00314.1 huMAP3_01026.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
RBL2	huMAP3_00487.1 huMAP3_03477.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12923.1 huMAP3_14722.1
MATCAP1	huMAP3_02340.1 huMAP3_04093.1 huMAP3_08857.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1
BDH2	huMAP3_02340.1 huMAP3_04093.1 huMAP3_08857.1 huMAP3_10958.1 huMAP3_11746.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_15208.1
CITED2	huMAP3_03756.1 huMAP3_11171.1 huMAP3_12870.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_13177.1
RBL1	huMAP3_00487.1 huMAP3_03164.1 huMAP3_03477.1 huMAP3_05269.1 huMAP3_05947.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10910.1 huMAP3_11168.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
C3orf62	huMAP3_12894.1 huMAP3_12923.1
CREBBP	huMAP3_01026.1 huMAP3_02340.1 huMAP3_04432.1 huMAP3_06547.1 huMAP3_06587.1 huMAP3_08026.1 huMAP3_09145.1 huMAP3_10449.1 huMAP3_10674.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1 huMAP3_14722.1
CITED1	huMAP3_02340.1 huMAP3_04093.1 huMAP3_08857.1 huMAP3_10958.1 huMAP3_12894.1 huMAP3_12923.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12923.1

Complex Portal: CPX-13422