hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12927.1
Complex Portal: CPX-14141
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | 5 | UniProt NCBI |
| CLEC4G | C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin) | 5 | UniProt NCBI |
| AP4S1 | AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) | 5 | UniProt NCBI |
| TEPSIN | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | 5 | UniProt NCBI |
| AP4M1 | AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4) | 5 | UniProt NCBI |
| DISC1 | Disrupted in schizophrenia 1 protein | 5 | UniProt NCBI |
| AP4E1 | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | 5 | UniProt NCBI |
| AP4B1 | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:67 | 3.36110250117e-12 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | AP4 adaptor complex |
| GO:0030124 | 1.84188417064e-09 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | AP-4 adaptor complex |
| HP:5200020 | 6.66013126519e-09 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal interest in others |
| HP:0100962 | 6.66013126519e-09 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Shyness |
| HP:0008807 | 1.53322372488e-07 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Acetabular dysplasia |
| HP:0002464 | 1.89356712338e-07 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Spastic dysarthria |
| HP:0010803 | 2.31385252934e-07 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Everted upper lip vermilion |
| REAC:R-HSA-432720 | 3.18690821415e-07 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Lysosome Vesicle Biogenesis |
| HP:0007020 | 6.46805844755e-07 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Progressive spastic paraplegia |
| HP:0002816 | 1.29124729367e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Genu recurvatum |
| HP:0002761 | 2.082249089e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Generalized joint hypermobility |
| HP:0025502 | 2.082249089e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Overweight |
| HP:0010500 | 2.32670907178e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Hyperextensibility of the knee |
| HP:0000297 | 3.88571869614e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Facial hypotonia |
| REAC:R-HSA-199992 | 7.08314138735e-06 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 1.61290616088e-05 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Lysosome |
| GO:0032588 | 2.31063155622e-05 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 TEPSIN | trans-Golgi network membrane |
| GO:0031904 | 2.74037293694e-05 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | endosome lumen |
| HP:0003170 | 4.01043730517e-05 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal acetabulum morphology |
| HP:0034670 | 4.22925762395e-05 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal knee physiology |
| GO:0030119 | 9.57879565037e-05 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | AP-type membrane coat adaptor complex |
| HP:0002307 | 0.000107808050141 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Drooling |
| HP:0000646 | 0.000117076544083 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Amblyopia |
| HP:0001258 | 0.000132079586227 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Spastic paraplegia |
| HP:0003781 | 0.000148474631478 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Excessive salivation |
| HP:0002515 | 0.000160218743167 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Waddling gait |
| HP:0002518 | 0.000329675572062 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal periventricular white matter morphology |
| HP:0010550 | 0.000329675572062 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Paraplegia |
| HP:0012433 | 0.00048617113366 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal social behavior |
| HP:0000341 | 0.000657041267163 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Narrow forehead |
| HP:0012472 | 0.000710549918626 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Eclabion |
| HP:0100755 | 0.00105272399502 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of salivation |
| HP:0002465 | 0.00107755090189 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Poor speech |
| HP:0000414 | 0.00107755090189 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Bulbous nose |
| HP:0010551 | 0.00167189420815 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Paraplegia/paraparesis |
| HP:0000154 | 0.00174245047648 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Wide mouth |
| GO:0005802 | 0.00186105996922 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 TEPSIN | trans-Golgi network |
| HP:0002061 | 0.00204705347764 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Lower limb spasticity |
| HP:0000280 | 0.00230026127264 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Coarse facial features |
| HP:0002352 | 0.00243526133051 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Leukoencephalopathy |
| HP:0000322 | 0.0033147586936 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Short philtrum |
| GO:0030117 | 0.00402583472149 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | membrane coat |
| GO:0048475 | 0.00402583472149 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | coated membrane |
| HP:0031432 | 0.00413193050427 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Restricted or repetitive behaviors or interests |
| HP:0000733 | 0.00413193050427 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal repetitive mannerisms |
| GO:0098791 | 0.0041718060775 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 TEPSIN | Golgi apparatus subcompartment |
| HP:0031828 | 0.00525098184782 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal superficial reflex |
| HP:0003487 | 0.00525098184782 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Babinski sign |
| HP:0002355 | 0.00558401920102 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Difficulty walking |
| HP:0031815 | 0.00738462133152 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal oral physiology |
| HP:0000301 | 0.00738462133152 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of facial musculature |
| HP:0007370 | 0.00916119500335 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Aplasia/Hypoplasia of the corpus callosum |
| HP:0002538 | 0.0101232347273 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Abnormal cerebral cortex morphology |
| HP:0002120 | 0.0105052319669 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Cerebral cortical atrophy |
| HP:0001763 | 0.0109195176361 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Pes planus |
| HP:0010864 | 0.0126987653037 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Intellectual disability, severe |
| HP:0001384 | 0.0135001393734 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal hip joint morphology |
| HP:0000436 | 0.0145105357891 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal nasal tip morphology |
| HP:0033725 | 0.0152863524979 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Thin corpus callosum |
| HP:0034353 | 0.0170850485916 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Appendicular spasticity |
| HP:0002815 | 0.017878944173 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of the knee |
| HP:0001762 | 0.0180816098631 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Talipes equinovarus |
| HP:0001273 | 0.0221994338924 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Abnormal corpus callosum morphology |
| HP:0011337 | 0.0225030563389 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of mouth size |
| HP:0007256 | 0.025775746302 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormal pyramidal sign |
| HP:0001272 | 0.0271235683575 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Cerebellar atrophy |
| HP:0011339 | 0.0296799266134 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of upper lip vermillion |
| REAC:R-HSA-199991 | 0.0307022914608 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Membrane Trafficking |
| HP:0004324 | 0.0317879075566 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Increased body weight |
| HP:0001883 | 0.0324099688455 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Talipes |
| HP:0001317 | 0.0333302835979 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Abnormal cerebellum morphology |
| HP:0005656 | 0.0336809946542 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Positional foot deformity |
| HP:0011283 | 0.0340676042959 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Abnormal metencephalon morphology |
| HP:0011282 | 0.0340676042959 | 0.625 | AP4B1 AP4M1 AP4S1 AP4E1 DISC1 | Abnormal hindbrain morphology |
| HP:0002079 | 0.0346581269173 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Hypoplasia of the corpus callosum |
| REAC:R-HSA-5653656 | 0.0379039189287 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Vesicle-mediated transport |
| HP:0004302 | 0.0391358955475 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Functional motor deficit |
| HP:0011799 | 0.0424763566953 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Abnormality of facial soft tissue |
| HP:0010549 | 0.0440265512457 | 0.5 | AP4B1 AP4M1 AP4S1 AP4E1 | Weakness due to upper motor neuron dysfunction |
| HP:0100021 | 0.0454488718917 | 0.375 | AP4M1 AP4S1 AP4E1 | Cerebral palsy |
| CORUM:7235 | 0.0499436884912 | 0.125 | DISC1 | DISC1-DRD2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP4E1 | TEPSIN | 1.0 | 0.138 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4S1 | AP4B1 | 1.0 | 0.172 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4E1 | AP4B1 | 1.0 | 0.284 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AP4M1 | AP4E1 | 1.0 | 0.17 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4M1 | TEPSIN | 1.0 | 0.078 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4M1 | AP4B1 | 0.999 | 0.18 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| AP4S1 | AP4M1 | 0.999 | 0.112 |
mutually_exclusive (Q9Y6B7)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| AP4S1 | AP4E1 | 0.999 | 0.166342857143 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4B1 | TEPSIN | 0.998 | 0.172 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4S1 | TEPSIN | 0.998 | 0.126 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4S1 | DISC1 | 0.994 | 0.066 |
structurally_consistent (O00189)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP4E1 | DISC1 | 0.993 | 0.154 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CLEC4G | TEPSIN | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AP4B1 | DISC1 | 0.978 | 0.134 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP4M1 | SUV39H2 | 0.943 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4E1 | SUV39H2 | 0.936 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4M1 | DISC1 | 0.925 | 0.122 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| AP4S1 | SUV39H2 | 0.914 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP4B1 | CLEC4G | 0.415 | bioplex3_WMM WMM_only | ||
| AP4E1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4M1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4S1 | CLEC4G | 0.274 | bioplex3_WMM WMM_only |
Related Complexes