hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12947.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK6 | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | 5 | UniProt NCBI |
| ANKS6 | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | 5 | UniProt NCBI |
| NEK7 | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | 5 | UniProt NCBI |
| ANKS3 | Ankyrin repeat and SAM domain-containing protein 3 | 5 | UniProt NCBI |
| ZNF214 | Zinc finger protein 214 (BWSCR2-associated zinc finger protein 1) (BAZ-1) | 3 | UniProt NCBI |
| NEK8 | Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) | 5 | UniProt NCBI |
| BICC1 | Protein bicaudal C homolog 1 (Bic-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6257 | 0.000123103089524 | 0.285714285714 | ANKS6 NEK8 | ANKS6-NEK8-INVS-NPHP3 complex |
| WP:WP4352 | 0.000124574325421 | 0.571428571429 | ANKS6 ANKS3 NEK8 NEK7 | Ciliary landscape |
| HP:0000105 | 0.00069792779823 | 0.428571428571 | ANKS6 BICC1 NEK8 | Enlarged kidney |
| REAC:R-HSA-2980767 | 0.000799384186586 | 0.285714285714 | NEK7 NEK6 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| WP:WP4803 | 0.0036650703234 | 0.428571428571 | ANKS6 NEK8 ANKS3 | Ciliopathies |
| HP:0000800 | 0.0046597529865 | 0.285714285714 | NEK8 BICC1 | Cystic renal dysplasia |
| HP:0003774 | 0.0141201557134 | 0.428571428571 | ANKS6 BICC1 NEK8 | Stage 5 chronic kidney disease |
| REAC:R-HSA-3301854 | 0.0199798926111 | 0.285714285714 | NEK7 NEK6 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-2980766 | 0.0407752524289 | 0.285714285714 | NEK7 NEK6 | Nuclear Envelope Breakdown |
| HP:0012622 | 0.0412791464602 | 0.428571428571 | ANKS6 BICC1 NEK8 | Chronic kidney disease |
| HP:0001407 | 0.0419603197237 | 0.285714285714 | NEK8 BICC1 | Hepatic cysts |
| WP:WP4656 | 0.0435709553271 | 0.285714285714 | ANKS6 NEK8 | Joubert syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEK6 | NEK7 | 0.997 | 0.338 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| NEK7 | ANKS3 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| ANKS3 | ANKS6 | 0.989 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only | |
| NEK6 | ANKS3 | 0.973 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ANKS3 | ZNF214 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ANKS3 | NEK8 | 0.919 | bioplex3_HEK293 bioplex3_WMM boldt WMM_only boldt_WMM | |
| ANKS3 | BICC1 | 0.918 | bioplex3_HEK293 bioplex3_WMM WMM_only boldt_WMM | |
| NEK7 | ANKS6 | 0.869 | 0.082 | bioplex3_HEK293 bioplex3_WMM boldt boldt_WMM WMM_only |
| BICC1 | NEK8 | 0.415 | bioplex3_WMM WMM_only | |
| ANKS6 | BICC1 | 0.413 | 0.114 | bioplex3_WMM WMM_only boldt_WMM |
| ANKS6 | NEK8 | 0.371 | bioplex3_WMM gupta () boldt boldt_WMM | |
| NEK7 | ZNF214 | 0.337 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NEK7 | NEK8 | 0.221 | bioplex3_WMM boldt WMM_only boldt_WMM | |
| NEK6 | ANKS6 | 0.175 | 0.076 | bioplex3_WMM WMM_only |
| NEK7 | BICC1 | 0.051 | 0.038 | bioplex3_WMM youn_WMM WMM_only |
| NEK6 | BICC1 | 0.008 | 0.032 | youn_WMM WMM_only |
Related Complexes