hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_12948.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| SEC31A | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 5.68434264714e-10 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | Amino acids regulate mTORC1 |
| KEGG:04150 | 3.06586313087e-08 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | mTOR signaling pathway |
| GO:1904262 | 4.58614910437e-08 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | negative regulation of TORC1 signaling |
| GO:0061700 | 4.97036464355e-08 | 0.666666666667 | CASTOR1 CASTOR2 MIOS WDR24 | GATOR2 complex |
| REAC:R-HSA-9711097 | 1.28814034961e-07 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | Cellular response to starvation |
| GO:0032007 | 2.69643647861e-07 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | negative regulation of TOR signaling |
| GO:0035859 | 2.81924903404e-07 | 0.666666666667 | CASTOR1 CASTOR2 MIOS WDR24 | Seh1-associated complex |
| GO:1903432 | 1.7640596292e-06 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | regulation of TORC1 signaling |
| GO:0038202 | 2.23176181384e-06 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | TORC1 signaling |
| REAC:R-HSA-2262752 | 2.64149968796e-06 | 1.0 | CASTOR2 WDR24 SEC31A MIOS CASTOR1 SESN2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 2.79926993011e-06 | 1.0 | CASTOR2 WDR24 SEC31A MIOS CASTOR1 SESN2 | Cellular responses to stimuli |
| GO:0032006 | 1.20814684781e-05 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | regulation of TOR signaling |
| GO:0031929 | 2.07823329526e-05 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | TOR signaling |
| GO:0034198 | 4.8500829726e-05 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | cellular response to amino acid starvation |
| GO:1990928 | 5.85430293603e-05 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | response to amino acid starvation |
| GO:1904263 | 9.04396960067e-05 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | positive regulation of TORC1 signaling |
| CORUM:6216 | 0.000170782642132 | 0.333333333333 | WDR24 MIOS | GATOR2 complex |
| GO:0032008 | 0.000265438603659 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | positive regulation of TOR signaling |
| CORUM:6753 | 0.000477929626316 | 0.333333333333 | WDR24 MIOS | SOG complex |
| CORUM:6217 | 0.000477929626316 | 0.333333333333 | WDR24 MIOS | GATOR complex |
| GO:0009267 | 0.00309479018871 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | cellular response to starvation |
| GO:1902532 | 0.00392183535385 | 0.833333333333 | CASTOR1 CASTOR2 SESN2 MIOS WDR24 | negative regulation of intracellular signal transduction |
| GO:0042594 | 0.00530363618926 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | response to starvation |
| GO:1903577 | 0.00702301080125 | 0.333333333333 | CASTOR1 CASTOR2 | cellular response to L-arginine |
| GO:0031669 | 0.0104603595373 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | cellular response to nutrient levels |
| GO:0071230 | 0.0114488243093 | 0.5 | CASTOR1 SESN2 CASTOR2 | cellular response to amino acid stimulus |
| GO:0031668 | 0.013015960717 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | cellular response to extracellular stimulus |
| GO:0071229 | 0.0148589937997 | 0.5 | CASTOR1 SESN2 CASTOR2 | cellular response to acid chemical |
| GO:0043200 | 0.017471616814 | 0.5 | CASTOR1 SESN2 CASTOR2 | response to amino acid |
| GO:1903576 | 0.0210651876021 | 0.333333333333 | CASTOR1 CASTOR2 | response to L-arginine |
| GO:0001101 | 0.0235785344663 | 0.5 | CASTOR1 SESN2 CASTOR2 | response to acid chemical |
| GO:0071496 | 0.0270492850378 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | cellular response to external stimulus |
| GO:0031667 | 0.0359397466361 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | response to nutrient levels |
| GO:0009991 | 0.043727602448 | 0.666666666667 | CASTOR1 SESN2 MIOS WDR24 | response to extracellular stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WDR24 | MIOS | 0.994 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| SEC31A | SESN2 | 0.96 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only |
| CASTOR1 | CASTOR2 | 0.917 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SEC31A | WDR24 | 0.902 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| CASTOR1 | MIOS | 0.9 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SEC31A | MIOS | 0.868 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () |
| CASTOR1 | WDR24 | 0.304 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes